DE69029861D1 - N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents

N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Info

Publication number
DE69029861D1
DE69029861D1 DE69029861T DE69029861T DE69029861D1 DE 69029861 D1 DE69029861 D1 DE 69029861D1 DE 69029861 T DE69029861 T DE 69029861T DE 69029861 T DE69029861 T DE 69029861T DE 69029861 D1 DE69029861 D1 DE 69029861D1
Authority
DE
Germany
Prior art keywords
pct
acyl
production
medicinal product
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029861T
Other languages
English (en)
Other versions
DE69029861T2 (de
Inventor
Roberto Dr Lo Zambeletti Colle
Giulio Dr Lo Zambeletti Dondio
Guiseppe Dr Lo Zambel Giardina
Lorenzo Dr Lo Zambelet Leurini
Vittorio Dr Lo Zamb Vecchietti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
SmithKline Beecham SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898926561A external-priority patent/GB8926561D0/en
Priority claimed from GB909003137A external-priority patent/GB9003137D0/en
Application filed by SmithKline Beecham SpA filed Critical SmithKline Beecham SpA
Publication of DE69029861D1 publication Critical patent/DE69029861D1/de
Application granted granted Critical
Publication of DE69029861T2 publication Critical patent/DE69029861T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
DE69029861T 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel Expired - Fee Related DE69029861T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898926561A GB8926561D0 (en) 1989-11-24 1989-11-24 Novel compounds
GB909003137A GB9003137D0 (en) 1990-02-12 1990-02-12 Novel compounds
PCT/EP1990/002011 WO1991008206A1 (en) 1989-11-24 1990-11-20 N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals

Publications (2)

Publication Number Publication Date
DE69029861D1 true DE69029861D1 (de) 1997-03-13
DE69029861T2 DE69029861T2 (de) 1997-07-10

Family

ID=26296247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029861T Expired - Fee Related DE69029861T2 (de) 1989-11-24 1990-11-20 N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel

Country Status (12)

Country Link
US (1) US5322848A (de)
EP (1) EP0501997B1 (de)
JP (1) JPH05501551A (de)
KR (1) KR927003571A (de)
AT (1) ATE148463T1 (de)
AU (1) AU641955B2 (de)
CA (1) CA2069423A1 (de)
DE (1) DE69029861T2 (de)
IE (1) IE904230A1 (de)
NZ (1) NZ236186A (de)
PT (1) PT95963A (de)
WO (1) WO1991008206A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428042A (en) * 1990-04-28 1995-06-27 Dr Lo Zambeletti S.P.A. 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists
AU1760992A (en) * 1991-05-21 1992-12-30 Dr. Lo Zambeletti S.P.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide
DE4407047A1 (de) * 1994-03-03 1995-09-07 Merck Patent Gmbh Acetamide
US6750216B2 (en) 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
AU2008232954A1 (en) 2007-03-30 2008-10-09 Tioga Pharmaceuticals Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3766335D1 (de) * 1986-09-17 1991-01-03 Zambeletti Spa L N-1-acylierte-(1-(phenyl- oder benzyl-))-1,2-aethylendiamine.
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
GB8804104D0 (en) * 1988-02-23 1988-03-23 Glaxo Group Ltd Chemical compounds
EP0330467A1 (de) * 1988-02-23 1989-08-30 Glaxo Group Limited Heterocyclische Verbindungen
KR890012970A (ko) * 1988-02-23 1989-09-20 추후보충 테트라히드로 이소퀴놀린 유도체
US4999359A (en) * 1988-03-16 1991-03-12 Dr. Lo Zambeletti S.P.A. Heterocyclic ethylene diamine compounds and their pharmaceutical compositions and methods
DE68924751T2 (de) * 1988-09-26 1996-04-11 Smithkline Beecham Farma Azacyclische Verbindungen, verwendbar als Arzneimittel.
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
US5322848A (en) 1994-06-21
WO1991008206A1 (en) 1991-06-13
PT95963A (pt) 1991-09-30
CA2069423A1 (en) 1991-05-25
JPH05501551A (ja) 1993-03-25
NZ236186A (en) 1993-09-27
AU6723190A (en) 1991-06-26
EP0501997A1 (de) 1992-09-09
ATE148463T1 (de) 1997-02-15
EP0501997B1 (de) 1997-01-29
AU641955B2 (en) 1993-10-07
DE69029861T2 (de) 1997-07-10
KR927003571A (ko) 1992-12-18
IE904230A1 (en) 1991-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee