CN1226294C - 稠合的杂芳族葡萄糖激酶活化剂 - Google Patents

稠合的杂芳族葡萄糖激酶活化剂 Download PDF

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Publication number
CN1226294C
CN1226294C CNB018194494A CN01819449A CN1226294C CN 1226294 C CN1226294 C CN 1226294C CN B018194494 A CNB018194494 A CN B018194494A CN 01819449 A CN01819449 A CN 01819449A CN 1226294 C CN1226294 C CN 1226294C
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CN
China
Prior art keywords
cyclopentyl
phenyl
propionamide
methanesulfonyl
mmol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018194494A
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English (en)
Chinese (zh)
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CN1476438A (zh
Inventor
温迪·利·科比特
约瑟夫·塞缪尔·格林伯西
南希－艾伦·海因斯
罗伯特·弗朗西斯·凯斯特
佩奇·埃兰·马哈尼
拉马坎斯·萨拉布
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1476438A publication Critical patent/CN1476438A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CNB018194494A 2000-12-06 2001-11-28 稠合的杂芳族葡萄糖激酶活化剂 Expired - Fee Related CN1226294C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06
US60/251,637 2000-12-06

Publications (2)

Publication Number Publication Date
CN1476438A CN1476438A (zh) 2004-02-18
CN1226294C true CN1226294C (zh) 2005-11-09

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018194494A Expired - Fee Related CN1226294C (zh) 2000-12-06 2001-11-28 稠合的杂芳族葡萄糖激酶活化剂

Country Status (21)

Country Link
US (3) US6545155B2 (enrdf_load_stackoverflow)
EP (1) EP1341774B1 (enrdf_load_stackoverflow)
JP (1) JP4109111B2 (enrdf_load_stackoverflow)
KR (1) KR100545431B1 (enrdf_load_stackoverflow)
CN (1) CN1226294C (enrdf_load_stackoverflow)
AR (1) AR031627A1 (enrdf_load_stackoverflow)
AT (1) ATE316965T1 (enrdf_load_stackoverflow)
AU (2) AU2002221902B2 (enrdf_load_stackoverflow)
BR (1) BR0115999A (enrdf_load_stackoverflow)
CA (1) CA2429642C (enrdf_load_stackoverflow)
DE (1) DE60117059T2 (enrdf_load_stackoverflow)
DK (1) DK1341774T3 (enrdf_load_stackoverflow)
ES (1) ES2256340T3 (enrdf_load_stackoverflow)
GT (1) GT200100243A (enrdf_load_stackoverflow)
MX (1) MXPA03005119A (enrdf_load_stackoverflow)
PA (1) PA8534301A1 (enrdf_load_stackoverflow)
PE (1) PE20020753A1 (enrdf_load_stackoverflow)
PT (1) PT1341774E (enrdf_load_stackoverflow)
UY (1) UY27055A1 (enrdf_load_stackoverflow)
WO (1) WO2002046173A1 (enrdf_load_stackoverflow)
ZA (1) ZA200303748B (enrdf_load_stackoverflow)

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ZA200303748B (en) 2004-08-16
PE20020753A1 (es) 2002-08-27
CA2429642C (en) 2007-11-20
US6545155B2 (en) 2003-04-08
MXPA03005119A (es) 2004-10-15
PT1341774E (pt) 2006-05-31
JP4109111B2 (ja) 2008-07-02
BR0115999A (pt) 2003-09-30
CA2429642A1 (en) 2002-06-13
DK1341774T3 (da) 2006-06-12
US6448399B1 (en) 2002-09-10
US6441184B1 (en) 2002-08-27
PA8534301A1 (es) 2002-08-26
US20020103241A1 (en) 2002-08-01
KR100545431B1 (ko) 2006-01-24
GT200100243A (es) 2002-06-04
DE60117059D1 (de) 2006-04-13
ATE316965T1 (de) 2006-02-15
AU2002221902B2 (en) 2006-11-23
US20020103199A1 (en) 2002-08-01
JP2004517087A (ja) 2004-06-10
UY27055A1 (es) 2002-07-31
KR20030068555A (ko) 2003-08-21
AR031627A1 (es) 2003-09-24
WO2002046173A1 (en) 2002-06-13
AU2190202A (en) 2002-06-18
ES2256340T3 (es) 2006-07-16
EP1341774A1 (en) 2003-09-10
EP1341774B1 (en) 2006-02-01
DE60117059T2 (de) 2006-10-26
CN1476438A (zh) 2004-02-18
US20020107396A1 (en) 2002-08-08

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