CN1215833C - 快速崩解的甲基纤维素片剂 - Google Patents

快速崩解的甲基纤维素片剂 Download PDF

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Publication number
CN1215833C
CN1215833C CN988102943A CN98810294A CN1215833C CN 1215833 C CN1215833 C CN 1215833C CN 988102943 A CN988102943 A CN 988102943A CN 98810294 A CN98810294 A CN 98810294A CN 1215833 C CN1215833 C CN 1215833C
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CN
China
Prior art keywords
tablet
methylcellulose
mixture
sodium
calcium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN988102943A
Other languages
English (en)
Chinese (zh)
Other versions
CN1276719A (zh
Inventor
B·达盖
N·I·梅塔
P·纳亚克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1276719A publication Critical patent/CN1276719A/zh
Application granted granted Critical
Publication of CN1215833C publication Critical patent/CN1215833C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN988102943A 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂 Expired - Fee Related CN1215833C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5689997P 1997-08-22 1997-08-22
US60/056,899 1997-08-22
US8766298P 1998-06-02 1998-06-02
US60/087,662 1998-06-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2004100115143A Division CN1660054A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Publications (2)

Publication Number Publication Date
CN1276719A CN1276719A (zh) 2000-12-13
CN1215833C true CN1215833C (zh) 2005-08-24

Family

ID=26735831

Family Applications (2)

Application Number Title Priority Date Filing Date
CN988102943A Expired - Fee Related CN1215833C (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂
CN2004100115143A Pending CN1660054A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2004100115143A Pending CN1660054A (zh) 1997-08-22 1998-08-21 快速崩解的甲基纤维素片剂

Country Status (16)

Country Link
US (9) US6350469B1 (https=)
EP (1) EP1005329A4 (https=)
JP (1) JP2001513545A (https=)
KR (3) KR100743767B1 (https=)
CN (2) CN1215833C (https=)
AR (1) AR017512A1 (https=)
AU (1) AU741326B2 (https=)
BR (1) BR9811980A (https=)
CA (1) CA2301135C (https=)
CO (1) CO4960651A1 (https=)
EA (1) EA004803B1 (https=)
MY (2) MY128046A (https=)
NZ (1) NZ502891A (https=)
PL (1) PL338858A1 (https=)
TW (1) TWI222869B (https=)
WO (1) WO1999009958A1 (https=)

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Also Published As

Publication number Publication date
US20050089561A1 (en) 2005-04-28
EA004803B1 (ru) 2004-08-26
KR100743767B1 (ko) 2007-07-30
US20050089564A1 (en) 2005-04-28
BR9811980A (pt) 2000-08-15
EA200000246A1 (ru) 2000-08-28
EP1005329A1 (en) 2000-06-07
TWI222869B (en) 2004-11-01
KR20010023197A (ko) 2001-03-26
US6350469B1 (en) 2002-02-26
WO1999009958A1 (en) 1999-03-04
CN1660054A (zh) 2005-08-31
AR017512A1 (es) 2001-09-12
NZ502891A (en) 2002-06-28
AU9202298A (en) 1999-03-16
CN1276719A (zh) 2000-12-13
AU741326B2 (en) 2001-11-29
KR20070116291A (ko) 2007-12-07
US20050089560A1 (en) 2005-04-28
CA2301135A1 (en) 1999-03-04
MY135183A (en) 2008-02-29
US20050089562A1 (en) 2005-04-28
JP2001513545A (ja) 2001-09-04
US20020086052A1 (en) 2002-07-04
US20050089563A1 (en) 2005-04-28
US20050089565A1 (en) 2005-04-28
PL338858A1 (en) 2000-11-20
US20030215505A1 (en) 2003-11-20
KR20070040424A (ko) 2007-04-16
CA2301135C (en) 2007-04-24
CO4960651A1 (es) 2000-09-25
US7125562B2 (en) 2006-10-24
EP1005329A4 (en) 2006-06-14
MY128046A (en) 2007-01-31

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