CN1208314C - 因子Ⅶa抑制剂(硫)脲衍生物,其制备方法及其用途 - Google Patents

因子Ⅶa抑制剂(硫)脲衍生物,其制备方法及其用途 Download PDF

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Publication number
CN1208314C
CN1208314C CNB018088309A CN01808830A CN1208314C CN 1208314 C CN1208314 C CN 1208314C CN B018088309 A CNB018088309 A CN B018088309A CN 01808830 A CN01808830 A CN 01808830A CN 1208314 C CN1208314 C CN 1208314C
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group
alkyl
formula
amino
phenyl
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Expired - Fee Related
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CNB018088309A
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English (en)
Chinese (zh)
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CN1427818A (zh
Inventor
O·克林格勒
M·舒多克
H－P·奈斯特勒
H·马特
H·施瑞德
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Sanofi Aventis Deutschland GmbH
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Aventis Pharma Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB018088309A 2000-06-06 2001-05-26 因子Ⅶa抑制剂(硫)脲衍生物,其制备方法及其用途 Expired - Fee Related CN1208314C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00112116A EP1162194A1 (en) 2000-06-06 2000-06-06 Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
EP00112116.9 2000-06-06

Publications (2)

Publication Number Publication Date
CN1427818A CN1427818A (zh) 2003-07-02
CN1208314C true CN1208314C (zh) 2005-06-29

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Family Applications (1)

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CNB018088309A Expired - Fee Related CN1208314C (zh) 2000-06-06 2001-05-26 因子Ⅶa抑制剂(硫)脲衍生物,其制备方法及其用途

Country Status (29)

Country Link
US (1) US6743790B2 (enExample)
EP (2) EP1162194A1 (enExample)
JP (1) JP4809570B2 (enExample)
KR (1) KR101011345B1 (enExample)
CN (1) CN1208314C (enExample)
AR (1) AR030936A1 (enExample)
AU (2) AU7749401A (enExample)
BR (1) BR0111264A (enExample)
CA (1) CA2410862C (enExample)
CZ (1) CZ20023963A3 (enExample)
DE (1) DE60139320D1 (enExample)
DK (1) DK1299354T3 (enExample)
EE (1) EE200200617A (enExample)
ES (1) ES2330412T3 (enExample)
HR (1) HRP20020961A2 (enExample)
HU (1) HUP0301631A2 (enExample)
IL (2) IL153220A0 (enExample)
MX (1) MXPA02009789A (enExample)
MY (1) MY129363A (enExample)
NO (1) NO328546B1 (enExample)
NZ (1) NZ522960A (enExample)
PL (1) PL359584A1 (enExample)
PT (1) PT1299354E (enExample)
RU (1) RU2286337C2 (enExample)
SK (1) SK17032002A3 (enExample)
TW (1) TWI283662B (enExample)
WO (1) WO2001094301A2 (enExample)
YU (1) YU89202A (enExample)
ZA (1) ZA200209018B (enExample)

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CA2483228C (en) * 2002-04-27 2011-07-05 Merck Patent Gesellschaft Mit Beschraenkter Haftung Carboxamides
CN1703395A (zh) * 2002-08-09 2005-11-30 特兰斯泰克制药公司 芳基和杂芳基化合物以及调节凝血的方法
JP2007500221A (ja) * 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
EP1628954A2 (en) * 2003-05-20 2006-03-01 Genentech, Inc. Acylsulfamide inhibitors of factor viia
JP2007501844A (ja) * 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
WO2006041119A1 (ja) * 2004-10-13 2006-04-20 Eisai R & D Management Co., Ltd. ヒドラジド誘導体
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP1856037A1 (en) * 2005-02-24 2007-11-21 Novo Nordisk Health Care AG Amidino-compounds for stabilizing factor vii polypeptide formulations
US20090041747A1 (en) * 2005-02-24 2009-02-12 Novo Nordisk Health Care Ag Compounds for Stabilizing Factor VII Polypeptide Formulations
JP2008531524A (ja) * 2005-02-24 2008-08-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチド製剤を安定化する化合物
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
MY146537A (en) 2006-03-24 2012-08-15 Eisai R&D Man Co Ltd Triazolone derivative
US8247442B2 (en) * 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
EP2202231A4 (en) 2007-09-21 2011-09-28 Eisai R&D Man Co Ltd 2,3-DIHYDROIMINOISOINDOLE DERIVATIVE
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
SI2770989T1 (sl) 2011-10-26 2018-12-31 Allergan, Inc. Aminokisline, substituirane z amidnimi derivati N-sečnine, kot so modulatorji receptorja za formil peptidnemu receptorju podobni receptor(FPRL-1)
AU2013249474A1 (en) * 2012-04-16 2014-11-06 Allergan, Inc. (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators
CN104717973A (zh) * 2012-10-10 2015-06-17 诺和诺德保健Ag（股份有限公司） 因子vii多肽的液体药物组合物
MX364916B (es) 2013-03-06 2019-05-13 Allergan Inc Uso de agonistas de receptor de péptido formilo 2 para tratar enfermadades inflamatorias oculares.
KR20210024691A (ko) 2013-03-06 2021-03-05 알러간, 인코포레이티드 피부 질환 치료용 포르밀 펩티드 수용체 2의 항진제의 용도

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Also Published As

Publication number Publication date
MXPA02009789A (es) 2003-03-12
HK1055941A1 (en) 2004-01-30
ES2330412T3 (es) 2009-12-10
EP1162194A1 (en) 2001-12-12
AR030936A1 (es) 2003-09-03
NO20025810L (no) 2002-12-03
PT1299354E (pt) 2009-10-01
EP1299354B1 (en) 2009-07-22
WO2001094301A2 (en) 2001-12-13
YU89202A (sh) 2006-05-25
AU2001277494B2 (en) 2006-05-04
ZA200209018B (en) 2003-10-08
HRP20020961A2 (en) 2004-12-31
EE200200617A (et) 2004-04-15
SK17032002A3 (sk) 2003-05-02
WO2001094301A3 (en) 2002-04-04
HUP0301631A2 (hu) 2003-09-29
US20020052417A1 (en) 2002-05-02
IL153220A0 (en) 2003-07-06
BR0111264A (pt) 2003-06-17
IL153220A (en) 2008-11-03
PL359584A1 (en) 2004-08-23
DK1299354T3 (da) 2009-11-16
NO328546B1 (no) 2010-03-15
JP4809570B2 (ja) 2011-11-09
NO20025810D0 (no) 2002-12-03
EP1299354A2 (en) 2003-04-09
CA2410862C (en) 2009-11-10
US6743790B2 (en) 2004-06-01
DE60139320D1 (de) 2009-09-03
KR101011345B1 (ko) 2011-01-28
AU7749401A (en) 2001-12-17
KR20030007911A (ko) 2003-01-23
CA2410862A1 (en) 2001-12-13
CN1427818A (zh) 2003-07-02
MY129363A (en) 2007-03-30
RU2286337C2 (ru) 2006-10-27
TWI283662B (en) 2007-07-11
CZ20023963A3 (cs) 2003-03-12
NZ522960A (en) 2004-05-28
JP2003535844A (ja) 2003-12-02

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