NO328546B1 - Faktor VIIA-inhibitoriske (tio)ureaderivater, deres fremstilling og farmasoytiske preparater omfattende slike. - Google Patents
Faktor VIIA-inhibitoriske (tio)ureaderivater, deres fremstilling og farmasoytiske preparater omfattende slike. Download PDFInfo
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- NO328546B1 NO328546B1 NO20025810A NO20025810A NO328546B1 NO 328546 B1 NO328546 B1 NO 328546B1 NO 20025810 A NO20025810 A NO 20025810A NO 20025810 A NO20025810 A NO 20025810A NO 328546 B1 NO328546 B1 NO 328546B1
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- formula
- ethyl
- phenyl
- compound
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- 238000002360 preparation method Methods 0.000 title claims description 8
- 230000002401 inhibitory effect Effects 0.000 title description 12
- 229940012414 factor viia Drugs 0.000 title description 5
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 150000003672 ureas Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 195
- -1 phenyloxycarbonyl- Chemical group 0.000 claims description 81
- 150000003839 salts Chemical class 0.000 claims description 49
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 27
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- 230000005764 inhibitory process Effects 0.000 claims description 16
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 239000003112 inhibitor Substances 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
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- 125000000524 functional group Chemical group 0.000 claims description 5
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- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C—CHEMISTRY; METALLURGY
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00112116A EP1162194A1 (en) | 2000-06-06 | 2000-06-06 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| PCT/EP2001/006029 WO2001094301A2 (en) | 2000-06-06 | 2001-05-26 | Factor viia inhibitory (thio)urea derivatives, their preparation and their use |
Publications (3)
| Publication Number | Publication Date |
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| NO20025810L NO20025810L (no) | 2002-12-03 |
| NO20025810D0 NO20025810D0 (no) | 2002-12-03 |
| NO328546B1 true NO328546B1 (no) | 2010-03-15 |
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| NO20025810A NO328546B1 (no) | 2000-06-06 | 2002-12-03 | Faktor VIIA-inhibitoriske (tio)ureaderivater, deres fremstilling og farmasoytiske preparater omfattende slike. |
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| US7183277B2 (en) | 2002-04-27 | 2007-02-27 | Merck Patent Gmbh | Carboxylic acid amides |
| US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| WO2004113316A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
| US7250447B2 (en) * | 2003-05-20 | 2007-07-31 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
| WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| US7501538B2 (en) * | 2003-08-08 | 2009-03-10 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| WO2006041119A1 (ja) * | 2004-10-13 | 2006-04-20 | Eisai R & D Management Co., Ltd. | ヒドラジド誘導体 |
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| JP2008531525A (ja) * | 2005-02-24 | 2008-08-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Ｖｉｉ因子ポリペプチド製剤を安定化する化合物 |
| EP1856037A1 (en) * | 2005-02-24 | 2007-11-21 | Novo Nordisk Health Care AG | Amidino-compounds for stabilizing factor vii polypeptide formulations |
| US20080312161A1 (en) * | 2005-02-24 | 2008-12-18 | Anders Klarskov Petersen | Compounds For Stabilizing Factor VII Polypeptide Formulations |
| WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| CA2647423C (en) | 2006-03-24 | 2015-02-17 | Eisai R&D Management Co., Ltd. | Triazolone derivative |
| US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
| TW200812963A (en) * | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
| TW200815353A (en) * | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| WO2009038157A1 (ja) | 2007-09-21 | 2009-03-26 | Eisai R & D Management Co., Ltd. | ２，３－ジヒドロ－イミノイソインドール誘導体 |
| US8765736B2 (en) * | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| PT2770989T (pt) | 2011-10-26 | 2018-12-04 | Allergan Inc | Derivados de amida de aminoácidos substituídos por n-ureia como moduladores de recetor tipo-1 do recetor de péptidos formil (fprl-1) |
| WO2013158597A1 (en) * | 2012-04-16 | 2013-10-24 | Allergan, Inc. | (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators |
| EP2906236A1 (en) * | 2012-10-10 | 2015-08-19 | Novo Nordisk Health Care AG | Liquid pharmaceutical composition of factor vii polypeptide |
| RU2663911C2 (ru) | 2013-03-06 | 2018-08-13 | Аллерган, Инк. | Применение агонистов формилпептидного рецептора 2 для лечения воспалительных заболеваний глаз |
| CA2899804A1 (en) | 2013-03-06 | 2014-09-12 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating dermatological diseases |
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| US5273982A (en) * | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
| US5506134A (en) | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| EP0570507A4 (en) * | 1991-02-05 | 1994-09-21 | Smithkline Beecham Corp | Anti-aggregatory peptides containing an aromatic ester or amide |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| JP3387948B2 (ja) * | 1992-12-04 | 2003-03-17 | 富山化学工業株式会社 | 新規なフェニルアラニン誘導体またはその塩 |
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| DE4309867A1 (de) * | 1993-03-26 | 1994-09-29 | Cassella Ag | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
| GB9313269D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Allophanic acid derivatives |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| WO1995008550A1 (en) * | 1993-09-24 | 1995-03-30 | Abbott Laboratories | Endothelin antagonists |
| AU7862794A (en) * | 1993-10-19 | 1995-05-08 | Sumitomo Pharmaceuticals Company, Limited | 2,3-diaminopropionic acid derivative |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| CA2243507A1 (en) * | 1996-01-30 | 1997-08-07 | Christopher J. Dinsmore | Inhibitors of farnesyl-protein transferase |
| PL192083B1 (pl) * | 1997-11-18 | 2006-08-31 | Dupont Pharmaceuticals Res Lab | Pochodne amin cyklicznych i ich zastosowanie |
| EP0987274A1 (en) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Factor VIIa Inhibitors |
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2000
- 2000-06-06 EP EP00112116A patent/EP1162194A1/en not_active Withdrawn
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2001
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- 2001-05-26 JP JP2002501818A patent/JP4809570B2/ja not_active Expired - Fee Related
- 2001-05-26 DK DK01955291T patent/DK1299354T3/da active
- 2001-05-26 CZ CZ20023963A patent/CZ20023963A3/cs unknown
- 2001-05-26 CA CA002410862A patent/CA2410862C/en not_active Expired - Fee Related
- 2001-05-26 EP EP01955291A patent/EP1299354B1/en not_active Expired - Lifetime
- 2001-05-26 IL IL15322001A patent/IL153220A0/xx unknown
- 2001-05-26 YU YU89202A patent/YU89202A/sh unknown
- 2001-05-26 HU HU0301631A patent/HUP0301631A2/hu unknown
- 2001-05-26 BR BR0111264-3A patent/BR0111264A/pt not_active IP Right Cessation
- 2001-05-26 SK SK1703-2002A patent/SK17032002A3/sk not_active Application Discontinuation
- 2001-05-26 PT PT01955291T patent/PT1299354E/pt unknown
- 2001-05-26 DE DE60139320T patent/DE60139320D1/de not_active Expired - Lifetime
- 2001-05-26 CN CNB018088309A patent/CN1208314C/zh not_active Expired - Fee Related
- 2001-05-26 KR KR1020027016691A patent/KR101011345B1/ko not_active Expired - Fee Related
- 2001-05-26 MX MXPA02009789A patent/MXPA02009789A/es active IP Right Grant
- 2001-05-26 WO PCT/EP2001/006029 patent/WO2001094301A2/en not_active Ceased
- 2001-05-26 AU AU2001277494A patent/AU2001277494B2/en not_active Ceased
- 2001-05-26 PL PL01359584A patent/PL359584A1/xx not_active Application Discontinuation
- 2001-05-26 EE EEP200200617A patent/EE200200617A/xx unknown
- 2001-05-26 NZ NZ522960A patent/NZ522960A/en unknown
- 2001-05-26 HR HRP20020961 patent/HRP20020961A2/hr not_active Application Discontinuation
- 2001-05-26 RU RU2002135308/04A patent/RU2286337C2/ru not_active IP Right Cessation
- 2001-06-04 AR ARP010102657A patent/AR030936A1/es active IP Right Grant
- 2001-06-04 TW TW090113412A patent/TWI283662B/zh not_active IP Right Cessation
- 2001-06-05 MY MYPI20012631A patent/MY129363A/en unknown
- 2001-06-06 US US09/874,318 patent/US6743790B2/en not_active Expired - Lifetime
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2002
- 2002-11-06 ZA ZA200209018A patent/ZA200209018B/en unknown
- 2002-12-02 IL IL153220A patent/IL153220A/en not_active IP Right Cessation
- 2002-12-03 NO NO20025810A patent/NO328546B1/no not_active IP Right Cessation
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