JP4809570B2 - 第ＶＩＩａ因子阻害剤である（チオ）尿素誘導体、その製造方法およびその使用 - Google Patents

第ＶＩＩａ因子阻害剤である（チオ）尿素誘導体、その製造方法およびその使用 Download PDF

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JP4809570B2
JP4809570B2 JP2002501818A JP2002501818A JP4809570B2 JP 4809570 B2 JP4809570 B2 JP 4809570B2 JP 2002501818 A JP2002501818 A JP 2002501818A JP 2002501818 A JP2002501818 A JP 2002501818A JP 4809570 B2 JP4809570 B2 JP 4809570B2
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group
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formula
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aryl
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JP2003535844A (ja
JP2003535844A5 (enExample
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オトマール・クリングラー
マンフレート・シュードック
ハンス−ペーター・ネストラー
ハンス・マター
ヘルマン・シュロイダー
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サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
JP2002501818A 2000-06-06 2001-05-26 第ＶＩＩａ因子阻害剤である（チオ）尿素誘導体、その製造方法およびその使用 Expired - Fee Related JP4809570B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00112116.9 2000-06-06
EP00112116A EP1162194A1 (en) 2000-06-06 2000-06-06 Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
PCT/EP2001/006029 WO2001094301A2 (en) 2000-06-06 2001-05-26 Factor viia inhibitory (thio)urea derivatives, their preparation and their use

Publications (3)

Publication Number Publication Date
JP2003535844A JP2003535844A (ja) 2003-12-02
JP2003535844A5 JP2003535844A5 (enExample) 2008-05-15
JP4809570B2 true JP4809570B2 (ja) 2011-11-09

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ID=8168926

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JP2002501818A Expired - Fee Related JP4809570B2 (ja) 2000-06-06 2001-05-26 第ＶＩＩａ因子阻害剤である（チオ）尿素誘導体、その製造方法およびその使用

Country Status (29)

Country Link
US (1) US6743790B2 (enExample)
EP (2) EP1162194A1 (enExample)
JP (1) JP4809570B2 (enExample)
KR (1) KR101011345B1 (enExample)
CN (1) CN1208314C (enExample)
AR (1) AR030936A1 (enExample)
AU (2) AU7749401A (enExample)
BR (1) BR0111264A (enExample)
CA (1) CA2410862C (enExample)
CZ (1) CZ20023963A3 (enExample)
DE (1) DE60139320D1 (enExample)
DK (1) DK1299354T3 (enExample)
EE (1) EE200200617A (enExample)
ES (1) ES2330412T3 (enExample)
HR (1) HRP20020961A2 (enExample)
HU (1) HUP0301631A2 (enExample)
IL (2) IL153220A0 (enExample)
MX (1) MXPA02009789A (enExample)
MY (1) MY129363A (enExample)
NO (1) NO328546B1 (enExample)
NZ (1) NZ522960A (enExample)
PL (1) PL359584A1 (enExample)
PT (1) PT1299354E (enExample)
RU (1) RU2286337C2 (enExample)
SK (1) SK17032002A3 (enExample)
TW (1) TWI283662B (enExample)
WO (1) WO2001094301A2 (enExample)
YU (1) YU89202A (enExample)
ZA (1) ZA200209018B (enExample)

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AU2003226755A1 (en) * 2002-04-27 2003-11-17 Merck Patent Gmbh Carboxylic acid amides
EP1546089A2 (en) * 2002-08-09 2005-06-29 TransTech Pharma Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
EP1628954A2 (en) * 2003-05-20 2006-03-01 Genentech, Inc. Acylsulfamide inhibitors of factor viia
AU2004249671A1 (en) * 2003-05-20 2004-12-29 Genentech, Inc. Benzofuran inhibitors of factor VIIa
JP2007501844A (ja) * 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド アリール及びヘテロアリール化合物、組成物並びに使用方法
US7459472B2 (en) * 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2006041119A1 (ja) * 2004-10-13 2006-04-20 Eisai R & D Management Co., Ltd. ヒドラジド誘導体
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
JP2008531523A (ja) * 2005-02-24 2008-08-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチド製剤を安定化する化合物
JP2008531525A (ja) * 2005-02-24 2008-08-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチド製剤を安定化する化合物
JP2008531524A (ja) * 2005-02-24 2008-08-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｖｉｉ因子ポリペプチド製剤を安定化する化合物
EP2360170A3 (en) 2005-06-17 2012-03-28 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered proteins comprinsing at least one non-native cysteine
WO2007111212A1 (ja) 2006-03-24 2007-10-04 Eisai R & D Management Co., Ltd. トリアゾロン誘導体
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
WO2007118853A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
JPWO2009038157A1 (ja) 2007-09-21 2011-01-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ２，３−ジヒドロ−イミノイソインドール誘導体
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
CN106518742B (zh) 2011-10-26 2020-01-21 阿勒根公司 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物
JP2015520130A (ja) * 2012-04-16 2015-07-16 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ホルミルペプチド受容体２調節物質としての（２−ウレイドアセトアミド）アルキル誘導体
WO2014057068A1 (en) 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide
BR112015021392B1 (pt) 2013-03-06 2021-11-16 Allergan, Inc Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas
BR112015021371B1 (pt) 2013-03-06 2021-04-13 Allergan, Inc Uso de agonistas de receptor de formil peptídeo 2 para tratar doenças inflamatórias oculares

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Also Published As

Publication number Publication date
CA2410862C (en) 2009-11-10
EP1162194A1 (en) 2001-12-12
MXPA02009789A (es) 2003-03-12
ES2330412T3 (es) 2009-12-10
PT1299354E (pt) 2009-10-01
HRP20020961A2 (en) 2004-12-31
EE200200617A (et) 2004-04-15
HUP0301631A2 (hu) 2003-09-29
CA2410862A1 (en) 2001-12-13
JP2003535844A (ja) 2003-12-02
RU2286337C2 (ru) 2006-10-27
YU89202A (sh) 2006-05-25
PL359584A1 (en) 2004-08-23
EP1299354B1 (en) 2009-07-22
ZA200209018B (en) 2003-10-08
NO20025810L (no) 2002-12-03
DK1299354T3 (da) 2009-11-16
US6743790B2 (en) 2004-06-01
KR20030007911A (ko) 2003-01-23
HK1055941A1 (en) 2004-01-30
DE60139320D1 (de) 2009-09-03
EP1299354A2 (en) 2003-04-09
TWI283662B (en) 2007-07-11
SK17032002A3 (sk) 2003-05-02
NO20025810D0 (no) 2002-12-03
CN1427818A (zh) 2003-07-02
AU7749401A (en) 2001-12-17
CN1208314C (zh) 2005-06-29
AR030936A1 (es) 2003-09-03
BR0111264A (pt) 2003-06-17
IL153220A (en) 2008-11-03
KR101011345B1 (ko) 2011-01-28
NZ522960A (en) 2004-05-28
US20020052417A1 (en) 2002-05-02
WO2001094301A2 (en) 2001-12-13
WO2001094301A3 (en) 2002-04-04
AU2001277494B2 (en) 2006-05-04
MY129363A (en) 2007-03-30
NO328546B1 (no) 2010-03-15
CZ20023963A3 (cs) 2003-03-12
IL153220A0 (en) 2003-07-06

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