CN1199963C - 具comt抑制活性的香豆素衍生物 - Google Patents

具comt抑制活性的香豆素衍生物 Download PDF

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Publication number
CN1199963C
CN1199963C CNB018121934A CN01812193A CN1199963C CN 1199963 C CN1199963 C CN 1199963C CN B018121934 A CNB018121934 A CN B018121934A CN 01812193 A CN01812193 A CN 01812193A CN 1199963 C CN1199963 C CN 1199963C
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CN
China
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alkyl
cooh
compound
substituents
membered
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Expired - Fee Related
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CNB018121934A
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English (en)
Chinese (zh)
Other versions
CN1440399A (zh
Inventor
J·皮斯蒂宁
M·奥瓦斯卡
J·维德格伦
T·洛塔
M·于利皮尔图拉－伊科宁
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Orion Oyj
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Orion Oyj
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Publication of CN1440399A publication Critical patent/CN1440399A/zh
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Publication of CN1199963C publication Critical patent/CN1199963C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNB018121934A 2000-07-03 2001-06-28 具comt抑制活性的香豆素衍生物 Expired - Fee Related CN1199963C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20001593 2000-07-03
FI20001593A FI20001593A7 (fi) 2000-07-03 2000-07-03 Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia

Publications (2)

Publication Number Publication Date
CN1440399A CN1440399A (zh) 2003-09-03
CN1199963C true CN1199963C (zh) 2005-05-04

Family

ID=8558717

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018121934A Expired - Fee Related CN1199963C (zh) 2000-07-03 2001-06-28 具comt抑制活性的香豆素衍生物

Country Status (27)

Country Link
US (1) US6951870B2 (OSRAM)
EP (1) EP1301503B1 (OSRAM)
JP (1) JP4851051B2 (OSRAM)
KR (1) KR20030040225A (OSRAM)
CN (1) CN1199963C (OSRAM)
AT (1) ATE260268T1 (OSRAM)
AU (2) AU7259701A (OSRAM)
BG (1) BG107513A (OSRAM)
BR (1) BR0111969A (OSRAM)
CA (1) CA2414787C (OSRAM)
DE (1) DE60102161T2 (OSRAM)
DK (1) DK1301503T3 (OSRAM)
EE (1) EE200300008A (OSRAM)
ES (1) ES2215919T3 (OSRAM)
FI (1) FI20001593A7 (OSRAM)
HU (1) HUP0301706A3 (OSRAM)
IL (2) IL153352A0 (OSRAM)
MX (1) MXPA02012657A (OSRAM)
NO (1) NO328699B1 (OSRAM)
NZ (1) NZ523121A (OSRAM)
PL (1) PL359068A1 (OSRAM)
PT (1) PT1301503E (OSRAM)
RU (1) RU2282627C2 (OSRAM)
SK (1) SK18452002A3 (OSRAM)
TR (1) TR200400802T4 (OSRAM)
WO (1) WO2002002548A1 (OSRAM)
ZA (1) ZA200210161B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2002951833A0 (en) * 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
CN1506359A (zh) 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
AU2005287865B2 (en) 2004-09-21 2012-02-16 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
RU2396244C1 (ru) * 2008-12-23 2010-08-10 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) Способ получения пурпурогаллина
ES2343347B2 (es) * 2009-01-27 2011-12-07 Universidade De Santiago De Compostela Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados.
WO2012061413A2 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚ｏ－甲基轉移酶活性抑制化合物
AU2016215515B2 (en) 2015-02-02 2020-04-30 Mei Pharma, Inc. Combination therapies
JP7007292B2 (ja) * 2015-12-18 2022-02-10 ケスター、ヒューバート 薬剤としての使用のため、特にパーキンソン病の治療のための新規二環式化合物
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺
CN116064607B (zh) * 2022-08-22 2025-04-18 西南大学 一种高活性o-甲基转移酶基因制备滨蒿内酯的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3973608A (en) * 1973-08-01 1976-08-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Microbial production of certain isoflavones
JPS5035393A (OSRAM) * 1973-08-01 1975-04-04
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB8816519D0 (en) 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
JP3166094B2 (ja) * 1993-09-08 2001-05-14 森永乳業株式会社 クマリン誘導体及びそれらの用途
JPH0892157A (ja) 1994-05-02 1996-04-09 F Hoffmann La Roche Ag プルプロガリン誘導体
GB9626472D0 (en) * 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors
HRP970529B1 (en) * 1997-10-02 2003-06-30 Pliva Pharm & Chem Works Novel hydroxy and polyhydroxy derivatives of cumarin, preparation thereof and antiviral action thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations

Also Published As

Publication number Publication date
AU7259701A (en) 2002-01-14
IL153352A (en) 2009-05-04
EE200300008A (et) 2004-08-16
IL153352A0 (en) 2003-07-06
ES2215919T3 (es) 2004-10-16
SK18452002A3 (sk) 2004-04-06
BR0111969A (pt) 2003-07-01
NO328699B1 (no) 2010-04-26
ATE260268T1 (de) 2004-03-15
HUP0301706A2 (hu) 2003-09-29
NO20026095D0 (no) 2002-12-18
DK1301503T3 (da) 2004-06-28
AU2001272597B9 (en) 2005-08-11
CA2414787A1 (en) 2002-01-10
JP4851051B2 (ja) 2012-01-11
PT1301503E (pt) 2004-06-30
NZ523121A (en) 2004-08-27
MXPA02012657A (es) 2003-05-14
TR200400802T4 (tr) 2004-07-21
EP1301503A1 (en) 2003-04-16
EP1301503B1 (en) 2004-02-25
CN1440399A (zh) 2003-09-03
AU2001272597B2 (en) 2005-07-21
ZA200210161B (en) 2004-03-15
RU2282627C2 (ru) 2006-08-27
DE60102161T2 (de) 2004-09-16
US20040110750A9 (en) 2004-06-10
KR20030040225A (ko) 2003-05-22
DE60102161D1 (de) 2004-04-01
PL359068A1 (pl) 2004-08-23
FI20001593A7 (fi) 2002-01-04
HUP0301706A3 (en) 2005-12-28
CA2414787C (en) 2010-12-14
US6951870B2 (en) 2005-10-04
WO2002002548A1 (en) 2002-01-10
US20030186975A1 (en) 2003-10-02
JP2004502684A (ja) 2004-01-29
BG107513A (bg) 2003-06-30
NO20026095L (no) 2003-03-03
FI20001593A0 (fi) 2000-07-03

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050504

Termination date: 20120628