CN1195340A - 法呢基蛋白转移酶抑制剂 - Google Patents
法呢基蛋白转移酶抑制剂 Download PDFInfo
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- CN1195340A CN1195340A CN96194206A CN96194206A CN1195340A CN 1195340 A CN1195340 A CN 1195340A CN 96194206 A CN96194206 A CN 96194206A CN 96194206 A CN96194206 A CN 96194206A CN 1195340 A CN1195340 A CN 1195340A
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- Prior art keywords
- aryl
- replace
- alkyl
- heterocycle
- piperazine
- Prior art date
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Classifications
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Hematology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US41282995A | 1995-03-29 | 1995-03-29 | |
US08/412,829 | 1995-03-29 | ||
US47069095A | 1995-06-06 | 1995-06-06 | |
US08/470,690 | 1995-06-06 | ||
US08/600,728 US5856326A (en) | 1995-03-29 | 1996-03-01 | Inhibitors of farnesyl-protein transferase |
US08/600,728 | 1996-03-01 |
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CN1195340A true CN1195340A (zh) | 1998-10-07 |
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CN96194206A Pending CN1195340A (zh) | 1995-03-29 | 1996-03-25 | 法呢基蛋白转移酶抑制剂 |
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EP (1) | EP0820445A1 (is) |
JP (1) | JP3043815B2 (is) |
CN (1) | CN1195340A (is) |
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AU (1) | AU710672B2 (is) |
BG (1) | BG101973A (is) |
BR (1) | BR9607953A (is) |
CA (1) | CA2216707A1 (is) |
CZ (1) | CZ306297A3 (is) |
EE (1) | EE9700314A (is) |
HR (1) | HRP960143A2 (is) |
HU (1) | HUP9801883A3 (is) |
IL (1) | IL117580A0 (is) |
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NZ (1) | NZ305254A (is) |
PL (1) | PL322549A1 (is) |
SK (1) | SK129297A3 (is) |
TR (1) | TR199701056T1 (is) |
WO (1) | WO1996030343A1 (is) |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110294713A (zh) * | 2018-03-22 | 2019-10-01 | 西华大学 | 一种咪唑甲胺类衍生物的制备方法 |
CN110294713B (zh) * | 2018-03-22 | 2022-08-02 | 西华大学 | 一种咪唑甲胺类衍生物的制备方法 |
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EP0820445A1 (en) | 1998-01-28 |
BG101973A (en) | 1998-05-29 |
IL117580A0 (en) | 1996-07-23 |
JPH10511098A (ja) | 1998-10-27 |
AU710672B2 (en) | 1999-09-23 |
HRP960143A2 (en) | 1998-04-30 |
HUP9801883A3 (en) | 2000-09-28 |
NZ305254A (en) | 1999-03-29 |
CA2216707A1 (en) | 1996-10-03 |
NO974457D0 (no) | 1997-09-26 |
MX9707459A (es) | 1997-12-31 |
TR199701056T1 (xx) | 1998-02-21 |
JP3043815B2 (ja) | 2000-05-22 |
PL322549A1 (en) | 1998-02-02 |
HUP9801883A2 (hu) | 1999-06-28 |
SK129297A3 (en) | 1998-05-06 |
BR9607953A (pt) | 1998-07-14 |
NO974457L (no) | 1997-11-28 |
IS4568A (is) | 1997-09-24 |
CZ306297A3 (cs) | 1998-03-18 |
EE9700314A (et) | 1998-06-15 |
AR002726A1 (es) | 1998-04-29 |
WO1996030343A1 (en) | 1996-10-03 |
AU5322396A (en) | 1996-10-16 |
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