CN1184968C - 治疗眼、耳和鼻的抗生素组合物 - Google Patents

治疗眼、耳和鼻的抗生素组合物 Download PDF

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Publication number
CN1184968C
CN1184968C CNB998115096A CN99811509A CN1184968C CN 1184968 C CN1184968 C CN 1184968C CN B998115096 A CNB998115096 A CN B998115096A CN 99811509 A CN99811509 A CN 99811509A CN 1184968 C CN1184968 C CN 1184968C
Authority
CN
China
Prior art keywords
antiinflammatory
purposes
pharmaceutical composition
topical ophthalmic
ophthalmic pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
CNB998115096A
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English (en)
Chinese (zh)
Other versions
CN1320035A (zh
Inventor
G·卡格尔
R·L·阿布希尔
D·W·斯特罗曼
J·M·扬尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1184968(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of CN1320035A publication Critical patent/CN1320035A/zh
Application granted granted Critical
Publication of CN1184968C publication Critical patent/CN1184968C/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB998115096A 1998-09-30 1999-09-29 治疗眼、耳和鼻的抗生素组合物 Ceased CN1184968C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10250498P 1998-09-30 1998-09-30
US10250698P 1998-09-30 1998-09-30
US60/102,506 1998-09-30
US60/102,504 1998-09-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100973271A Division CN100374114C (zh) 1998-09-30 1999-09-29 治疗眼、耳和鼻的抗生素组合物

Publications (2)

Publication Number Publication Date
CN1320035A CN1320035A (zh) 2001-10-31
CN1184968C true CN1184968C (zh) 2005-01-19

Family

ID=26799441

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB998115096A Ceased CN1184968C (zh) 1998-09-30 1999-09-29 治疗眼、耳和鼻的抗生素组合物
CNB2004100973271A Expired - Lifetime CN100374114C (zh) 1998-09-30 1999-09-29 治疗眼、耳和鼻的抗生素组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2004100973271A Expired - Lifetime CN100374114C (zh) 1998-09-30 1999-09-29 治疗眼、耳和鼻的抗生素组合物

Country Status (18)

Country Link
EP (5) EP2301541B1 (enExample)
JP (5) JP2002525317A (enExample)
KR (1) KR101463243B1 (enExample)
CN (2) CN1184968C (enExample)
AR (2) AR020661A1 (enExample)
AT (2) ATE501732T1 (enExample)
AU (1) AU762827B2 (enExample)
BR (1) BRPI9914151B1 (enExample)
CA (3) CA2342211C (enExample)
CY (3) CY1111404T1 (enExample)
DE (2) DE69943287D1 (enExample)
DK (5) DK2796138T3 (enExample)
ES (4) ES2519190T3 (enExample)
HK (1) HK1038691B (enExample)
PT (5) PT1384478E (enExample)
TR (2) TR200100883T2 (enExample)
TW (1) TWI222361B (enExample)
WO (1) WO2000018386A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224802A (zh) * 2014-09-19 2014-12-24 南京优科生物医药研究有限公司 一种盐酸莫西沙星滴耳剂及其制备方法

Families Citing this family (36)

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US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6509327B1 (en) * 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
DE19937115A1 (de) * 1999-08-06 2001-02-08 Bayer Ag Wäßrige Arzneimittelformulierung von Moxifloxacin oder Salzen davon
DE19937116A1 (de) * 1999-08-06 2001-02-08 Bayer Ag Moxifloxacin Kochsalzformulierung
DE60006262T2 (de) 1999-09-24 2004-05-13 Alcon, Inc. Topische suspensionsformulierungen enthaltend ciprofloxacin und dexamethason
DE19962470A1 (de) 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
AU2001261748A1 (en) * 2000-05-19 2001-12-03 Alcon Laboratories Inc. Antibiotic compositions for treatment of the eye, ear and nose
CA2412575C (en) 2000-07-26 2009-12-29 Onkar N. Singh Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone
AU2002214308A1 (en) * 2000-11-16 2002-05-27 Wakamoto Pharmaceutical Co., Ltd. Antibacterial gel eye drops
WO2002049633A2 (en) 2000-12-20 2002-06-27 Alcon, Inc. Use of amidoamines to treat or prevent acanthamoeba and fungal infections
WO2002049627A2 (en) * 2000-12-20 2002-06-27 Alcon, Inc. Antifungal compositions containing an antibiotic and one or more amidoamines
US20030139382A1 (en) 2001-09-21 2003-07-24 Alcon, Inc. Method of treating middle ear infections
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
PL1666477T3 (pl) 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
WO2006015545A1 (fr) * 2004-08-11 2006-02-16 Shenzhen Tys R & D Co., Ltd. Capsule de gelatine de moxifloxacin et procede pour sa preparation
US20080124385A1 (en) * 2004-09-03 2008-05-29 Piedmont Pharmaceuticals,Llc. Methods for Transmembrane Treatment and Prevention of Otitis Media
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
EP1824499A2 (en) * 2004-12-10 2007-08-29 Alcon Inc. Compositions for treatment of ear infections
CN101317847B (zh) * 2007-06-06 2010-10-13 深圳市瑞谷医药技术有限公司 一种眼用或耳鼻用药物组合物及其用途
TWI544934B (zh) 2008-06-09 2016-08-11 愛爾康研究有限公司 含有氟喹諾酮抗生素藥物之經改良藥學組成物
JP5784012B2 (ja) * 2009-07-02 2015-09-24 アルコン リサーチ， リミテッド 眼、耳または鼻の感染症を処置するためのフィナフロキサシンを含む組成物および方法
LT2521547T (lt) * 2010-01-07 2017-12-11 Regents Of The University Of Minnesota Moksifloksacino vartojimo į ausį būdai ir kompozicijos
WO2013085769A1 (en) 2011-12-06 2013-06-13 Alcon Research, Ltd. Cellulosic gel composition with improved viscosity stability
RU2472507C1 (ru) * 2012-02-01 2013-01-20 Закрытое акционерное общество "Брынцалов-А" Водный состав на основе моксифлоксацина для парентерального введения
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
RU2595837C2 (ru) * 2014-09-29 2016-08-27 Открытое Акционерное Общество "Татхимфармпрепараты" Состав и способ получения глазных капель
EP3369422A4 (en) * 2015-10-29 2018-12-05 Teika Pharmaceutical Co., Ltd. External preparation
US12042500B2 (en) * 2018-04-03 2024-07-23 Hyderabad Eye Research Foundation Mucoadhesive drug delivery system for ocular administration of fluoroquinolone antibiotics
IT201900005280A1 (it) * 2019-04-05 2020-10-05 Ntc S R L Composizione otologica
JP2023530254A (ja) * 2020-06-10 2023-07-14 オキュラー サイエンス，インク． 手術後の眼科的ケアのための組成物および方法
CN116270662A (zh) * 2021-12-03 2023-06-23 苏州欧康维视生物科技有限公司 盐酸莫西沙星地塞米松磷酸钠滴眼液
KR102656260B1 (ko) 2022-10-14 2024-04-09 주식회사태준제약 목시플록사신을 포함하는 안과용 조성물

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BR9812553B1 (pt) * 1997-09-25 2010-06-01 formulação medicamentosa em pélete de difusão controlada e em um sistema matriz.
WO2000016736A1 (en) 1998-09-23 2000-03-30 Unilever N.V. Oral care compositions
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104224802A (zh) * 2014-09-19 2014-12-24 南京优科生物医药研究有限公司 一种盐酸莫西沙星滴耳剂及其制备方法
CN104224802B (zh) * 2014-09-19 2017-12-12 南京优科生物医药研究有限公司 一种盐酸莫西沙星滴耳剂及其制备方法

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DK2269602T3 (en) 2014-12-15
TWI222361B (en) 2004-10-21
JP2013018799A (ja) 2013-01-31
EP2796138A1 (en) 2014-10-29
EP2269602A1 (en) 2011-01-05
EP2796138B1 (en) 2016-08-17
BRPI9914151B1 (pt) 2017-10-03
CN1650863A (zh) 2005-08-10
DK2301541T3 (da) 2014-09-01
EP1117401B1 (en) 2003-11-19
ES2519190T3 (es) 2014-11-06
EP1384478A1 (en) 2004-01-28
CA2342211A1 (en) 2000-04-06
AR081393A2 (es) 2012-08-29
TR200100883T2 (tr) 2001-10-22
DK2796138T3 (en) 2016-12-05
JP2009007375A (ja) 2009-01-15
CN100374114C (zh) 2008-03-12
BR9914151A (pt) 2001-06-26
KR101463243B1 (ko) 2014-12-17
CY1115916T1 (el) 2017-01-25
DK1117401T3 (da) 2004-02-23
ES2526521T3 (es) 2015-01-13
TR200704370T2 (tr) 2007-11-21
ATE501732T1 (de) 2011-04-15
WO2000018386A2 (en) 2000-04-06
EP1384478B1 (en) 2011-03-16
ATE254458T1 (de) 2003-12-15
PT2269602E (pt) 2014-12-29
DK1384478T3 (da) 2011-05-23
AU1310100A (en) 2000-04-17
CA2342211C (en) 2009-05-26
EP2269602B1 (en) 2014-11-19
HK1150769A1 (en) 2012-01-13
DE69912972T2 (de) 2004-04-22
JP2002525317A (ja) 2002-08-13
CA2659064A1 (en) 2000-04-06
EP2301541B1 (en) 2014-08-20
CY1115759T1 (el) 2017-01-25
EP1117401A2 (en) 2001-07-25
CN1320035A (zh) 2001-10-31
JP5563041B2 (ja) 2014-07-30
JP2012067141A (ja) 2012-04-05
DE69943287D1 (de) 2011-04-28
PT2796138T (pt) 2016-09-22
JP2014144982A (ja) 2014-08-14
PT1384478E (pt) 2011-05-12
HK1150756A1 (en) 2012-01-13
PT1117401E (pt) 2004-03-31
BRPI9914151B8 (enExample) 2021-05-25
PT2301541E (pt) 2014-10-29
HK1059572A1 (en) 2004-07-09
ES2207307T3 (es) 2004-05-16
AR020661A1 (es) 2002-05-22
WO2000018386A3 (en) 2000-06-08
ES2602956T3 (es) 2017-02-23
AU762827B2 (en) 2003-07-03
EP2301541A1 (en) 2011-03-30
HK1038691A1 (en) 2002-03-28
KR20010075138A (ko) 2001-08-09
CA2774207A1 (en) 2000-04-06
DE69912972D1 (de) 2003-12-24
CY1111404T1 (el) 2015-08-05
HK1038691B (en) 2004-04-23

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