CN118406148A - 针对madcam的抗体 - Google Patents

针对madcam的抗体 Download PDF

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Publication number
CN118406148A
CN118406148A CN202410182126.9A CN202410182126A CN118406148A CN 118406148 A CN118406148 A CN 118406148A CN 202410182126 A CN202410182126 A CN 202410182126A CN 118406148 A CN118406148 A CN 118406148A
Authority
CN
China
Prior art keywords
madcam
antibody
antibodies
seq
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202410182126.9A
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English (en)
Chinese (zh)
Inventor
K·安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN118406148A publication Critical patent/CN118406148A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202410182126.9A 2017-07-14 2018-07-13 针对madcam的抗体 Pending CN118406148A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762532809P 2017-07-14 2017-07-14
US62/532,809 2017-07-14
CN201880056875.XA CN111032694B (zh) 2017-07-14 2018-07-13 针对madcam的抗体
PCT/US2018/042052 WO2019014572A1 (en) 2017-07-14 2018-07-13 ANTIBODIES DIRECTED AGAINST MADCAM

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880056875.XA Division CN111032694B (zh) 2017-07-14 2018-07-13 针对madcam的抗体

Publications (1)

Publication Number Publication Date
CN118406148A true CN118406148A (zh) 2024-07-30

Family

ID=63209653

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202410182126.9A Pending CN118406148A (zh) 2017-07-14 2018-07-13 针对madcam的抗体
CN201880056875.XA Active CN111032694B (zh) 2017-07-14 2018-07-13 针对madcam的抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880056875.XA Active CN111032694B (zh) 2017-07-14 2018-07-13 针对madcam的抗体

Country Status (25)

Country Link
US (2) US20190169291A1 (https=)
EP (1) EP3652211A1 (https=)
JP (1) JP7160491B2 (https=)
KR (1) KR102787394B1 (https=)
CN (2) CN118406148A (https=)
AR (1) AR112336A1 (https=)
AU (1) AU2018300189B2 (https=)
BR (1) BR112020000698A2 (https=)
CA (1) CA3069914A1 (https=)
CL (1) CL2020000102A1 (https=)
CO (1) CO2020000352A2 (https=)
CR (1) CR20200076A (https=)
CU (1) CU20200002A7 (https=)
DO (1) DOP2020000005A (https=)
EA (1) EA202090286A1 (https=)
EC (1) ECSP20011317A (https=)
IL (1) IL272015A (https=)
MA (1) MA48241A1 (https=)
MX (1) MX2023014363A (https=)
NI (1) NI202000004A (https=)
PE (1) PE20200616A1 (https=)
PH (1) PH12020500100A1 (https=)
SG (1) SG11202000298VA (https=)
TW (1) TW201920266A (https=)
WO (1) WO2019014572A1 (https=)

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Publication number Publication date
BR112020000698A2 (pt) 2020-07-14
PE20200616A1 (es) 2020-03-11
WO2019014572A1 (en) 2019-01-17
JP2020533953A (ja) 2020-11-26
AR112336A1 (es) 2019-10-16
JP7160491B2 (ja) 2022-10-25
CN111032694B (zh) 2024-03-08
CL2020000102A1 (es) 2020-10-09
KR20200028006A (ko) 2020-03-13
MX2023014363A (es) 2023-12-15
US20220119521A1 (en) 2022-04-21
AU2018300189A1 (en) 2020-01-30
NI202000004A (es) 2020-03-30
ECSP20011317A (es) 2020-12-31
EA202090286A1 (ru) 2020-05-12
US20190169291A1 (en) 2019-06-06
DOP2020000005A (es) 2021-02-15
US11802156B2 (en) 2023-10-31
IL272015A (en) 2020-02-27
PH12020500100A1 (en) 2020-09-14
CU20200002A7 (es) 2020-11-30
CN111032694A (zh) 2020-04-17
CO2020000352A2 (es) 2020-04-13
MA48241A1 (fr) 2021-03-31
KR102787394B1 (ko) 2025-03-26
CA3069914A1 (en) 2019-01-17
SG11202000298VA (en) 2020-02-27
CR20200076A (es) 2020-06-10
AU2018300189B2 (en) 2025-05-15
EP3652211A1 (en) 2020-05-20
TW201920266A (zh) 2019-06-01

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