CN118359610A - Menin-mll相互作用的抑制剂 - Google Patents
Menin-mll相互作用的抑制剂 Download PDFInfo
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- CN118359610A CN118359610A CN202410398451.9A CN202410398451A CN118359610A CN 118359610 A CN118359610 A CN 118359610A CN 202410398451 A CN202410398451 A CN 202410398451A CN 118359610 A CN118359610 A CN 118359610A
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- CN
- China
- Prior art keywords
- pyrrolo
- methyl
- pyridin
- fluoro
- isopropyl
- Prior art date
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- Pending
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- 238000000034 method Methods 0.000 claims description 188
- -1 mercapto Chemical group 0.000 claims description 161
- 125000000217 alkyl group Chemical group 0.000 claims description 160
- 150000003839 salts Chemical class 0.000 claims description 102
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- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 87
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 79
- 125000001424 substituent group Chemical group 0.000 claims description 69
- 125000003118 aryl group Chemical group 0.000 claims description 58
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- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 52
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 52
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 41
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
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- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 27
- 125000000336 imidazol-5-yl group Chemical group [H]N1C([H])=NC([H])=C1[*] 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 24
- 125000004966 cyanoalkyl group Chemical group 0.000 claims description 24
- 125000003545 alkoxy group Chemical group 0.000 claims description 23
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 23
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 12
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- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims description 9
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- 125000003282 alkyl amino group Chemical group 0.000 claims description 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 9
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 8
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims description 8
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- 125000005647 linker group Chemical group 0.000 claims description 8
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- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 6
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 6
- KLOVPYLMWUSHIH-HNKWHGCMSA-N C(C)(=O)N[C@@H]1CC[C@H](CC1)CCN1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F Chemical compound C(C)(=O)N[C@@H]1CC[C@H](CC1)CCN1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F KLOVPYLMWUSHIH-HNKWHGCMSA-N 0.000 claims description 6
- 208000014767 Myeloproliferative disease Diseases 0.000 claims description 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
- 230000002489 hematologic effect Effects 0.000 claims description 6
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims description 6
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 6
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 5
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 5
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- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 4
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims description 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 4
- WANMUPQOZKLHFO-FCMXBYMOSA-N FC1=CC(=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CC[C@@H]1CC[C@H](CC1)NC(OC(C)(C)C)=O)C(N(C)C(C)C)=O Chemical compound FC1=CC(=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CC[C@@H]1CC[C@H](CC1)NC(OC(C)(C)C)=O)C(N(C)C(C)C)=O WANMUPQOZKLHFO-FCMXBYMOSA-N 0.000 claims description 4
- WYECQGNASWOGNW-HNKWHGCMSA-N FC1=CC(=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)C[C@@H]1CC[C@H](CC1)NC(OC(C)(C)C)=O)C(N(C)C(C)C)=O Chemical compound FC1=CC(=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)C[C@@H]1CC[C@H](CC1)NC(OC(C)(C)C)=O)C(N(C)C(C)C)=O WYECQGNASWOGNW-HNKWHGCMSA-N 0.000 claims description 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 208000003747 lymphoid leukemia Diseases 0.000 claims description 4
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- 208000017604 Hodgkin disease Diseases 0.000 claims description 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 3
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims description 3
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 3
- 201000002797 childhood leukemia Diseases 0.000 claims description 3
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 230000009826 neoplastic cell growth Effects 0.000 claims description 3
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 3
- SRGUIEOVCQHJSZ-UHFFFAOYSA-N 1-[2-(cyclopropylmethoxy)-4-fluorophenyl]-3-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]pyrrolo[2,3-c]pyridine Chemical compound C1(CC1)COC1=C(C=CC(=C1)F)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CC1=CC=C(C=C1)F SRGUIEOVCQHJSZ-UHFFFAOYSA-N 0.000 claims description 2
- PBHDVHHSEKDSDQ-UHFFFAOYSA-N 2-[3-(1-benzylpiperidin-4-yl)pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-(2-hydroxyethyl)-N-propan-2-ylbenzamide Chemical compound C(C1=CC=CC=C1)N1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C(C)C)CCO)C=C(C=C1)F PBHDVHHSEKDSDQ-UHFFFAOYSA-N 0.000 claims description 2
- FJGZIHPNPBZSOX-UHFFFAOYSA-N 2-[3-(2-benzylpiperidin-4-yl)pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C(C1=CC=CC=C1)C1NCCC(C1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F FJGZIHPNPBZSOX-UHFFFAOYSA-N 0.000 claims description 2
- YXUSKCJKQISSTB-UHFFFAOYSA-N 2-[3-[1-[(4-acetamidophenyl)methyl]piperidin-4-yl]pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C(C)(=O)NC1=CC=C(CN2CCC(CC2)C2=CN(C3=CN=CC=C32)C2=C(C(=O)N(C)C(C)C)C=C(C=C2)F)C=C1 YXUSKCJKQISSTB-UHFFFAOYSA-N 0.000 claims description 2
- CHFLZGSUOZVSDZ-UHFFFAOYSA-N 2-[3-[1-[2-[4-(2-cyanopropan-2-yl)phenyl]ethyl]piperidin-4-yl]pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C(#N)C(C)(C)C1=CC=C(CCN2CCC(CC2)C2=CN(C3=CN=CC=C32)C2=C(C(=O)N(C)C(C)C)C=C(C=C2)F)C=C1 CHFLZGSUOZVSDZ-UHFFFAOYSA-N 0.000 claims description 2
- ZHKFYGPNAQZUQQ-UHFFFAOYSA-N 5-[[4-[1-(4-fluorophenyl)pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl]methyl]-4-methyl-1H-indole-2-carbonitrile Chemical compound FC1=CC=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CC=1C(=C2C=C(NC2=CC=1)C#N)C ZHKFYGPNAQZUQQ-UHFFFAOYSA-N 0.000 claims description 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims description 2
- IJEZLNMOVRCPNW-OJBMAJLDSA-N C(C)(=O)N[C@@H]1CC[C@H](CC1)CN1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F Chemical compound C(C)(=O)N[C@@H]1CC[C@H](CC1)CN1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F IJEZLNMOVRCPNW-OJBMAJLDSA-N 0.000 claims description 2
- 208000035561 Leukaemic infiltration brain Diseases 0.000 claims description 2
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- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims description 2
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- 230000002071 myeloproliferative effect Effects 0.000 claims description 2
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- LFKDJXLFVYVEFG-UHFFFAOYSA-N tert-butyl carbamate Chemical compound CC(C)(C)OC(N)=O LFKDJXLFVYVEFG-UHFFFAOYSA-N 0.000 claims description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 2
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- AOWUERVCHHESOK-UHFFFAOYSA-N 4-methyl-5-[[4-(5-phenylpyrrolo[3,2-d]pyrimidin-7-yl)piperidin-1-yl]methyl]-1H-indole-2-carbonitrile Chemical compound CC1=C2C=C(NC2=CC=C1CN1CCC(CC1)C1=CN(C2=C1N=CN=C2)C1=CC=CC=C1)C#N AOWUERVCHHESOK-UHFFFAOYSA-N 0.000 claims 2
- AXLYOFDTQBTULH-UHFFFAOYSA-N 5-(4-fluorophenyl)-7-[1-(1H-indol-5-ylmethyl)piperidin-4-yl]pyrrolo[3,2-d]pyrimidine Chemical compound N1C=CC2=CC(=CC=C12)CN1CCC(CC1)C1=CN(C2=C1N=CN=C2)C1=CC=C(C=C1)F AXLYOFDTQBTULH-UHFFFAOYSA-N 0.000 claims 2
- NZFUXGOJCWWYMP-UHFFFAOYSA-N 5-(4-fluorophenyl)-7-[1-(1H-indol-6-ylmethyl)piperidin-4-yl]pyrrolo[3,2-d]pyrimidine Chemical compound N1C=CC2=CC=C(C=C12)CN1CCC(CC1)C1=CN(C2=C1N=CN=C2)C1=CC=C(C=C1)F NZFUXGOJCWWYMP-UHFFFAOYSA-N 0.000 claims 2
- QDWHYRSSQXPBDB-UHFFFAOYSA-N 5-(4-fluorophenyl)-7-[1-(oxan-4-ylmethyl)piperidin-4-yl]pyrrolo[3,2-d]pyrimidine Chemical compound FC1=CC=C(C=C1)N1C=C(C=2N=CN=CC=21)C1CCN(CC1)CC1CCOCC1 QDWHYRSSQXPBDB-UHFFFAOYSA-N 0.000 claims 2
- IOEZYVRGJIYSHS-UHFFFAOYSA-N 5-[[4-[3-(4-fluorophenyl)-2-oxoimidazo[4,5-c]pyridin-1-yl]piperidin-1-yl]methyl]-4-methyl-1H-indole-2-carbonitrile Chemical compound FC1=CC=C(C=C1)N1C(N(C2=C1C=NC=C2)C1CCN(CC1)CC=1C(=C2C=C(NC2=CC=1)C#N)C)=O IOEZYVRGJIYSHS-UHFFFAOYSA-N 0.000 claims 2
- NBZBGHGDHAQDIR-UHFFFAOYSA-N 5-[[4-[5-(3-fluorophenyl)pyrrolo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]methyl]-4-methyl-1H-indole-2-carbonitrile Chemical compound FC=1C=C(C=CC=1)N1C=C(C=2N=CN=CC=21)C1CCN(CC1)CC=1C(=C2C=C(NC2=CC=1)C#N)C NBZBGHGDHAQDIR-UHFFFAOYSA-N 0.000 claims 2
- KVNSGAWZHWZWJX-UHFFFAOYSA-N 5-[[4-[5-(4-fluorophenyl)pyrrolo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]methyl]-4-methyl-1H-indole-2-carbonitrile Chemical compound FC1=CC=C(C=C1)N1C=C(C=2N=CN=CC=21)C1CCN(CC1)CC=1C(=C2C=C(NC2=CC=1)C#N)C KVNSGAWZHWZWJX-UHFFFAOYSA-N 0.000 claims 2
- AMKJRAVIJSEBGW-SAIGFBBZSA-N C(C1=CC=CC=C1)(=O)N[C@@H]1CC[C@H](CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F Chemical compound C(C1=CC=CC=C1)(=O)N[C@@H]1CC[C@H](CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F AMKJRAVIJSEBGW-SAIGFBBZSA-N 0.000 claims 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 2
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims 2
- XIXQEFDSHZNZJN-UHFFFAOYSA-N 1-(4-fluorophenyl)-3-[1-(3-methylbutyl)piperidin-4-yl]pyrrolo[2,3-c]pyridine Chemical compound FC1=CC=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CCC(C)C XIXQEFDSHZNZJN-UHFFFAOYSA-N 0.000 claims 1
- ZDUIYLWRQYRZMM-UHFFFAOYSA-N 1-methyl-5-[[4-(5-phenylpyrrolo[3,2-d]pyrimidin-7-yl)piperidin-1-yl]methyl]indole-2-carbonitrile Chemical compound CN1C(=CC2=CC(=CC=C12)CN1CCC(CC1)C1=CN(C2=C1N=CN=C2)C1=CC=CC=C1)C#N ZDUIYLWRQYRZMM-UHFFFAOYSA-N 0.000 claims 1
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- RPYKXJCTCQRJBH-UHFFFAOYSA-N 2-[1-[1-[(2-cyano-4-methyl-1H-indol-5-yl)methyl]piperidin-4-yl]-2-oxoimidazo[4,5-c]pyridin-3-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C(#N)C=1NC2=CC=C(C(=C2C=1)C)CN1CCC(CC1)N1C(N(C=2C=NC=CC=21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F)=O RPYKXJCTCQRJBH-UHFFFAOYSA-N 0.000 claims 1
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- QFWUZXFDJJGYKV-UHFFFAOYSA-N 2-[3-(1-benzylpiperidin-4-yl)pyrrolo[2,3-c]pyridin-1-yl]-N-ethyl-5-fluoro-N-propan-2-ylbenzamide Chemical compound C(C1=CC=CC=C1)N1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C(C)C)CC)C=C(C=C1)F QFWUZXFDJJGYKV-UHFFFAOYSA-N 0.000 claims 1
- GNRUAVDVINTFNZ-UHFFFAOYSA-N 2-[3-(2-azaspiro[3.5]nonan-7-yl)pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C1NCC11CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F GNRUAVDVINTFNZ-UHFFFAOYSA-N 0.000 claims 1
- XAXUJCHREYFUBA-UHFFFAOYSA-N 2-[3-[1-(2,3-dihydro-1H-indene-2-carbonyl)piperidin-4-yl]pyrrolo[2,3-c]pyridin-1-yl]-5-fluoro-N-methyl-N-propan-2-ylbenzamide Chemical compound C1C(CC2=CC=CC=C12)C(=O)N1CCC(CC1)C1=CN(C2=CN=CC=C21)C1=C(C(=O)N(C)C(C)C)C=C(C=C1)F XAXUJCHREYFUBA-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395618P | 2016-09-16 | 2016-09-16 | |
| US62/395,618 | 2016-09-16 | ||
| PCT/US2017/051780 WO2018053267A1 (en) | 2016-09-16 | 2017-09-15 | Inhibitors of the menin-mll interaction |
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| US10899738B2 (en) | 2016-05-02 | 2021-01-26 | The Regents Of The University Of Michigan | Piperidines as menin inhibitors |
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| TW202239407A (zh) | 2020-12-17 | 2022-10-16 | 瑞典商阿斯特捷利康公司 | Ｎ－（２－（４－氰基四氫噻唑－３－基）－２－側氧基乙基）－喹啉－４－甲醯胺 |
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