KR102536029B1 - 메닌-ｍｌｌ 상호작용의 억제제 - Google Patents
메닌-ｍｌｌ 상호작용의 억제제 Download PDFInfo
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- KR102536029B1 KR102536029B1 KR1020197010730A KR20197010730A KR102536029B1 KR 102536029 B1 KR102536029 B1 KR 102536029B1 KR 1020197010730 A KR1020197010730 A KR 1020197010730A KR 20197010730 A KR20197010730 A KR 20197010730A KR 102536029 B1 KR102536029 B1 KR 102536029B1
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- South Korea
- Prior art keywords
- pyrrolo
- methyl
- fluoro
- pyridin
- isopropyl
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| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| AU2017235462B2 (en) | 2016-03-16 | 2021-07-01 | Kura Oncology, Inc. | Bridged bicyclic inhibitors of menin-MLL and methods of use |
| RS64261B1 (sr) | 2016-03-16 | 2023-07-31 | Kura Oncology Inc | Supstituisani derivati tieno[2,3-d]pirimidina kao inhibitori menin-mll i načini upotrebe |
| SG11201809714TA (en) | 2016-05-02 | 2018-11-29 | Univ Michigan Regents | Piperidines as menin inhibitors |
| PT3468966T (pt) | 2016-06-10 | 2020-11-10 | Vitae Pharmaceuticals Llc | Inibidores da interação menina-mll |
| LT3512857T (lt) | 2016-09-14 | 2021-04-12 | Janssen Pharmaceutica Nv | Menin-mll sąveikos spirobicikliniai inhibitoriai |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| US10611778B2 (en) | 2016-09-14 | 2020-04-07 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
| MX2019003091A (es) * | 2016-09-16 | 2019-07-08 | Vitae Pharmaceuticals Inc | Inhibidores de la interaccion de menina-mll. |
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| JP2020515571A (ja) | 2017-03-31 | 2020-05-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 共有結合性メニン阻害剤としてのピペリジン |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
| KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| WO2019146740A1 (ja) * | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する環式化合物 |
| US11325921B2 (en) | 2018-03-30 | 2022-05-10 | Sumitomo Dainippon Pharma Co., Ltd. | Optically active crosslinked cyclic secondary amine derivative |
| AU2019327006B2 (en) | 2018-08-27 | 2024-02-15 | Sumitomo Pharma Co., Ltd. | Optically active azabicyclic derivative |
| HUE069830T2 (hu) * | 2018-09-13 | 2025-04-28 | Kissei Pharmaceutical | Imidazopiridinon vegyület |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| US20230030720A1 (en) | 2018-12-06 | 2023-02-02 | Daiichi Sankyo Company, Limited | Cycloalkane-1,3-diamine derivative |
| KR102779693B1 (ko) * | 2019-09-20 | 2025-03-12 | 노파르티스 아게 | Mll1 억제제 및 항암제 |
| WO2021060453A1 (ja) * | 2019-09-27 | 2021-04-01 | 大日本住友製薬株式会社 | 架橋型光学活性２級アミン誘導体 |
| UA129208C2 (uk) | 2019-12-19 | 2025-02-05 | Янссен Фармацевтика Нв | Заміщені спіропохідні з прямим ланцюгом |
| EP4085056A1 (en) | 2020-01-03 | 2022-11-09 | Berg LLC | Polycyclic amides as ube2k modulators for treating cancer |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| TW202200589A (zh) * | 2020-05-28 | 2022-01-01 | 瑞士商諾華公司 | Ｍｌｌ１抑制劑及抗癌劑 |
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| BR112023023154A2 (pt) | 2021-05-08 | 2024-01-23 | Janssen Pharmaceutica Nv | Derivados espiro substituídos |
| CN117730081A (zh) | 2021-05-08 | 2024-03-19 | 詹森药业有限公司 | 取代的螺环衍生物 |
| EP4337203A4 (en) | 2021-05-14 | 2025-04-09 | Syndax Pharmaceuticals, Inc. | INHIBITORS OF THE MENIN-MLL INTERACTION |
| WO2022253167A1 (en) | 2021-06-01 | 2022-12-08 | Janssen Pharmaceutica Nv | SUBSTITUTED PHENYL-1H-PYRROLO [2, 3-c] PYRIDINE DERIVATIVES |
| EP4347600A1 (en) | 2021-06-03 | 2024-04-10 | JANSSEN Pharmaceutica NV | Pyridazines or 1,2,4-triazines substituted by spirocyclic amines |
| CA3220099A1 (en) | 2021-06-17 | 2022-12-22 | Wei Cai | (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cance |
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