JP2019529421A - ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤 - Google Patents

ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤 Download PDF

Info

Publication number
JP2019529421A
JP2019529421A JP2019514787A JP2019514787A JP2019529421A JP 2019529421 A JP2019529421 A JP 2019529421A JP 2019514787 A JP2019514787 A JP 2019514787A JP 2019514787 A JP2019514787 A JP 2019514787A JP 2019529421 A JP2019529421 A JP 2019529421A
Authority
JP
Japan
Prior art keywords
pyrrolo
methyl
fluoro
pyridin
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019514787A
Other languages
English (en)
Japanese (ja)
Inventor
カケーシャン サルバチオン
カケーシャン サルバチオン
エー．クレアモン デイビッド
エー．クレアモン デイビッド
トン チョンクオ
トン チョンクオ
ファン イー
ファン イー
チア ランチー
チア ランチー
ディー．ロテスタ スティーブン
ディー．ロテスタ スティーブン
ビー．シン スレッシュ
ビー．シン スレッシュ
ベンカトラマン シャンカー
ベンカトラマン シャンカー
ユアン チン
ユアン チン
チョン ヤーチュン
チョン ヤーチュン
チョアン リンハン
チョアン リンハン
Original Assignee
ヴァイティー ファーマシューティカルズ，エルエルシー
ヴァイティー ファーマシューティカルズ，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヴァイティー ファーマシューティカルズ，エルエルシー, ヴァイティー ファーマシューティカルズ，エルエルシー filed Critical ヴァイティー ファーマシューティカルズ，エルエルシー
Publication of JP2019529421A publication Critical patent/JP2019529421A/ja
Priority to JP2022161777A priority Critical patent/JP2022189853A/ja
Priority to JP2024195965A priority patent/JP2025022910A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019514787A 2016-09-16 2017-09-15 ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤 Withdrawn JP2019529421A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022161777A JP2022189853A (ja) 2016-09-16 2022-10-06 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤
JP2024195965A JP2025022910A (ja) 2016-09-16 2024-11-08 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662395618P 2016-09-16 2016-09-16
US62/395,618 2016-09-16
PCT/US2017/051780 WO2018053267A1 (en) 2016-09-16 2017-09-15 Inhibitors of the menin-mll interaction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022161777A Division JP2022189853A (ja) 2016-09-16 2022-10-06 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤

Publications (1)

Publication Number Publication Date
JP2019529421A true JP2019529421A (ja) 2019-10-17

Family

ID=59966892

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019514787A Withdrawn JP2019529421A (ja) 2016-09-16 2017-09-15 ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤
JP2022161777A Pending JP2022189853A (ja) 2016-09-16 2022-10-06 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤
JP2024195965A Pending JP2025022910A (ja) 2016-09-16 2024-11-08 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022161777A Pending JP2022189853A (ja) 2016-09-16 2022-10-06 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤
JP2024195965A Pending JP2025022910A (ja) 2016-09-16 2024-11-08 ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤

Country Status (16)

Country Link
US (3) US10899758B2 (enExample)
EP (2) EP3512850B1 (enExample)
JP (3) JP2019529421A (enExample)
KR (1) KR102536029B1 (enExample)
CN (2) CN118359610A (enExample)
AR (1) AR109658A1 (enExample)
AU (1) AU2017326006B2 (enExample)
CA (1) CA3036987A1 (enExample)
DK (1) DK3512850T3 (enExample)
ES (1) ES2948949T3 (enExample)
FI (1) FI3512850T3 (enExample)
IL (2) IL265028B (enExample)
MX (2) MX2019003091A (enExample)
PL (1) PL3512850T3 (enExample)
TW (1) TWI757340B (enExample)
WO (1) WO2018053267A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548618A (ja) * 2019-09-20 2022-11-21 ノバルティス アーゲー Ｍｌｌ１阻害剤及び抗癌剤

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
AR104020A1 (es) 2015-06-04 2017-06-21 Kura Oncology Inc Métodos y composiciones para inhibir la interacción de menina con proteínas mill
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
BR112018068702A2 (pt) 2016-03-16 2019-01-15 Kura Oncology Inc inibidores bicíclicos em ponte de menin-mll e métodos de uso
CN114539284A (zh) 2016-03-16 2022-05-27 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
US10899738B2 (en) 2016-05-02 2021-01-26 The Regents Of The University Of Michigan Piperidines as menin inhibitors
HRP20201771T1 (hr) 2016-06-10 2021-02-19 Vitae Pharmaceuticals, Llc Inhibitori interakcije menin-mll
AU2017326487B2 (en) 2016-09-14 2021-08-05 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
US10611778B2 (en) 2016-09-14 2020-04-07 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-MLL interaction
CA3036987A1 (en) * 2016-09-16 2018-03-22 Vitae Pharmaceuticals, Inc. Inhibitors of the menin-mll interaction
MX391405B (es) 2016-12-15 2025-03-21 Janssen Pharmaceutica Nv Inhibidores de azepano de la interacción menina-mll.
US11944627B2 (en) 2017-03-24 2024-04-02 Kura Oncology, Inc. Methods for treating hematological malignancies and Ewing's sarcoma
BR112019020130A2 (pt) 2017-03-31 2020-04-22 Univ Michigan Regents piperidinas como inibidores covalentes de menin
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
US11396517B1 (en) 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction
JP7250405B2 (ja) * 2018-01-26 2023-04-03 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
JP7239562B2 (ja) 2018-03-30 2023-03-14 住友ファーマ株式会社 光学活性な架橋型環状２級アミン誘導体
EP3845533A4 (en) * 2018-08-27 2022-04-27 Sumitomo Dainippon Pharma Co., Ltd. OPTICALLY ACTIVE AZABICYCLIC DERIVATIVE
KR102830577B1 (ko) * 2018-09-13 2025-07-08 깃세이 야쿠힌 고교 가부시키가이샤 이미다조피리디논 화합물
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
TW202039512A (zh) 2018-12-06 2020-11-01 日商第一三共股份有限公司 環烷-1,3-二胺化合物
US20220380365A1 (en) * 2019-09-27 2022-12-01 Sumitomo Dainippon Pharma Co., Ltd. Crosslinked optically active secondary amine derivative
AU2020404305A1 (en) 2019-12-19 2022-08-04 Janssen Pharmaceutica Nv Substituted straight chain spiro derivatives
AU2020417293A1 (en) 2020-01-03 2022-09-01 Berg Llc Polycyclic amides as UBE2K modulators for treating cancer
CN111297863B (zh) * 2020-03-30 2021-06-25 四川大学华西医院 menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用
TW202200589A (zh) 2020-05-28 2022-01-01 瑞士商諾華公司 Ｍｌｌ１抑制劑及抗癌劑
TW202239407A (zh) 2020-12-17 2022-10-16 瑞典商阿斯特捷利康公司 Ｎ－（２－（４－氰基四氫噻唑－３－基）－２－側氧基乙基）－喹啉－４－甲醯胺
CN117321049A (zh) 2021-05-08 2023-12-29 詹森药业有限公司 取代的螺环衍生物
MX2023013176A (es) 2021-05-08 2023-12-01 Janssen Pharmaceutica Nv Derivados espiro sustituidos.
AU2022274325A1 (en) 2021-05-14 2023-10-05 Syndax Pharmaceuticals, Inc. Inhibitors of the menin-mll interaction
PE20242359A1 (es) 2021-06-01 2024-12-16 Janssen Pharmaceutica Nv Derivados de fenil-1h-pirrolo[2,3-c]piridina sustituidos
CA3218340A1 (en) 2021-06-03 2022-12-08 Janssen Pharmaceutica Nv Pyridazines or 1,2,4-triazines substituted by spirocyclic amines
IL309359A (en) 2021-06-17 2024-02-01 Janssen Pharmaceutica Nv (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cancer
CN116903609A (zh) * 2021-11-05 2023-10-20 上海优理惠生医药有限公司 一种化合物、包含其的药物组合物及其应用
WO2023084320A1 (en) * 2021-11-11 2023-05-19 V-Ensure Pharma Technologies Private Limited Reconstitutable, single use antidiabetic compositions
WO2023193790A1 (en) * 2022-04-08 2023-10-12 Janssen Pharmaceutica Nv Crystalline forms of an inhibitor of the menin/mll interaction
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
WO2024114658A1 (en) * 2022-11-30 2024-06-06 Janssen Pharmaceutica Nv Substituted 1-phenyl-3, 4-dihydropyrido [3, 4-d] pyrimidin-2-one derivatives
CN120322230A (zh) * 2022-11-30 2025-07-15 詹森药业有限公司 包含多发性内分泌癌蛋白-mll抑制剂和至少一种其他治疗剂的组合
JP2025540682A (ja) * 2022-11-30 2025-12-16 ヤンセン ファーマシューティカ エヌ．ベー． シクロブチル置換二環式化合物
WO2024114666A1 (en) * 2022-11-30 2024-06-06 Janssen Pharmaceutica Nv Combinations comprising a menin-mll inhibitor and a bcl-2 inhibitor
AR132185A1 (es) * 2023-03-24 2025-06-04 Acerta Pharma Bv COMPUESTOS DE 1-H-PIRROLO[2,3-c]PIRIDINA
WO2025067111A1 (zh) * 2023-09-27 2025-04-03 苏州必扬医药科技有限公司 一种Menin-MLL相互作用抑制剂及其制备方法和应用
WO2025119184A1 (zh) * 2023-12-04 2025-06-12 首药控股(北京)股份有限公司 取代的多环化合物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002527359A (ja) * 1998-09-18 2002-08-27 ビーエーエスエフ アクチェンゲゼルシャフト キナーゼインヒビターとしての４−アミノピロリピリミジン
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
WO2011152351A1 (ja) * 2010-05-31 2011-12-08 小野薬品工業株式会社 プリノン誘導体
JP2013529179A (ja) * 2010-03-15 2013-07-18 プロクシマゲン リミテッド 新規酵素阻害化合物
JP2014532060A (ja) * 2011-10-03 2014-12-04 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 癌を治療するためのピロロピリミジン化合物
JP2015537033A (ja) * 2012-11-15 2015-12-24 ファーマサイクリックス，インク． キナーゼ阻害剤としてのピロロピリミジン化合物
WO2016143896A1 (ja) * 2015-03-11 2016-09-15 国立研究開発法人理化学研究所 難治性白血病治療薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE524467T1 (de) 2005-04-25 2011-09-15 Merck Patent Gmbh Neuartige aza-heterozyklen als kinase-inhibitoren
US8377946B1 (en) * 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2014017659A1 (ja) * 2012-07-27 2014-01-30 独立行政法人理化学研究所 急性骨髄性白血病の治療又は再発抑制剤
AU2014279863A1 (en) * 2013-06-12 2016-01-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
EP3057970A1 (en) * 2013-10-18 2016-08-24 Medivation Technologies, Inc. Heterocyclic compounds and methods of use
CA3036987A1 (en) * 2016-09-16 2018-03-22 Vitae Pharmaceuticals, Inc. Inhibitors of the menin-mll interaction

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002527359A (ja) * 1998-09-18 2002-08-27 ビーエーエスエフ アクチェンゲゼルシャフト キナーゼインヒビターとしての４−アミノピロリピリミジン
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
JP2013529179A (ja) * 2010-03-15 2013-07-18 プロクシマゲン リミテッド 新規酵素阻害化合物
WO2011152351A1 (ja) * 2010-05-31 2011-12-08 小野薬品工業株式会社 プリノン誘導体
JP2014532060A (ja) * 2011-10-03 2014-12-04 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 癌を治療するためのピロロピリミジン化合物
JP2015537033A (ja) * 2012-11-15 2015-12-24 ファーマサイクリックス，インク． キナーゼ阻害剤としてのピロロピリミジン化合物
WO2016143896A1 (ja) * 2015-03-11 2016-09-15 国立研究開発法人理化学研究所 難治性白血病治療薬

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548618A (ja) * 2019-09-20 2022-11-21 ノバルティス アーゲー Ｍｌｌ１阻害剤及び抗癌剤
JP7344372B2 (ja) 2019-09-20 2023-09-13 ノバルティス アーゲー Ｍｌｌ１阻害剤及び抗癌剤

Also Published As

Publication number Publication date
PL3512850T3 (pl) 2023-10-09
CN110325533A (zh) 2019-10-11
US11739085B2 (en) 2023-08-29
NZ751049A (en) 2025-05-02
IL265028B (en) 2022-09-01
BR112019005030A2 (pt) 2019-06-18
RU2019111169A (ru) 2020-10-20
TW201825486A (zh) 2018-07-16
CN110325533B (zh) 2025-11-04
AR109658A1 (es) 2019-01-09
EP3512850B1 (en) 2023-04-12
WO2018053267A1 (en) 2018-03-22
MX2019003091A (es) 2019-07-08
JP2022189853A (ja) 2022-12-22
TWI757340B (zh) 2022-03-11
US20190202830A1 (en) 2019-07-04
EP4230627A3 (en) 2023-11-15
KR20190111008A (ko) 2019-10-01
KR102536029B1 (ko) 2023-05-23
CN118359610A (zh) 2024-07-19
AU2017326006B2 (en) 2021-10-28
US20240124447A1 (en) 2024-04-18
IL295972A (en) 2022-10-01
AU2017326006A1 (en) 2019-03-21
FI3512850T3 (fi) 2023-06-20
EP4230627A2 (en) 2023-08-23
US10899758B2 (en) 2021-01-26
EP3512850A1 (en) 2019-07-24
RU2019111169A3 (enExample) 2020-12-30
ES2948949T3 (es) 2023-09-22
MX2022013841A (es) 2022-11-30
CA3036987A1 (en) 2018-03-22
JP2025022910A (ja) 2025-02-14
DK3512850T3 (da) 2023-07-03
US20210179611A1 (en) 2021-06-17
IL265028A (enExample) 2019-04-30

Similar Documents

Publication Publication Date Title
US11739085B2 (en) Inhibitors of the menin-MLL interaction
JP7461390B2 (ja) メニン－ｍｌｌ相互作用の阻害剤
JP2018538330A (ja) ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤
RU2829484C2 (ru) Ингибиторы взаимодействия менин-mll
HK40098918A (en) Inhibitors of the menin-mll interaction
BR112019005030B1 (pt) Compostos, sais, formas cristalinas, composições farmacêuticas e seus usos como inibidores da interação de menin-llm
HK40012443B (en) Inhibitors of the menin-mll interaction
HK40012443A (en) Inhibitors of the menin-mll interaction
BR112018075260B1 (pt) Compostos inibidores da interação de menina-llm, composição farmacêutica, sal, forma cristalina e uso dos mesmos

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200901

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210715

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211101

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220203

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220607

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221006

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20221006

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20221007

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20221101

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20221121

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20221122

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20221206