TWI757340B - 梅嫩蛋白（ｍｅｎｉｎ）-ＭＬＬ相互作用之抑制劑 - Google Patents
梅嫩蛋白（ｍｅｎｉｎ）-ＭＬＬ相互作用之抑制劑 Download PDFInfo
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- TWI757340B TWI757340B TW106131767A TW106131767A TWI757340B TW I757340 B TWI757340 B TW I757340B TW 106131767 A TW106131767 A TW 106131767A TW 106131767 A TW106131767 A TW 106131767A TW I757340 B TWI757340 B TW I757340B
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- pyrrolo
- methyl
- fluoro
- pyridin
- isopropyl
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- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 2
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 claims description 2
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- KVNSGAWZHWZWJX-UHFFFAOYSA-N 5-[[4-[5-(4-fluorophenyl)pyrrolo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]methyl]-4-methyl-1H-indole-2-carbonitrile Chemical compound FC1=CC=C(C=C1)N1C=C(C=2N=CN=CC=21)C1CCN(CC1)CC=1C(=C2C=C(NC2=CC=1)C#N)C KVNSGAWZHWZWJX-UHFFFAOYSA-N 0.000 claims 2
- MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 claims 2
- XIXQEFDSHZNZJN-UHFFFAOYSA-N 1-(4-fluorophenyl)-3-[1-(3-methylbutyl)piperidin-4-yl]pyrrolo[2,3-c]pyridine Chemical compound FC1=CC=C(C=C1)N1C=C(C=2C1=CN=CC=2)C1CCN(CC1)CCC(C)C XIXQEFDSHZNZJN-UHFFFAOYSA-N 0.000 claims 1
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| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| US10588907B2 (en) | 2015-06-04 | 2020-03-17 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
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