CN117321087A - 包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 - Google Patents

包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 Download PDF

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Publication number
CN117321087A
CN117321087A CN202280032592.8A CN202280032592A CN117321087A CN 117321087 A CN117321087 A CN 117321087A CN 202280032592 A CN202280032592 A CN 202280032592A CN 117321087 A CN117321087 A CN 117321087A
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domain
polypeptide
protein
nkp46
abd
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CN202280032592.8A
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Chinese (zh)
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S·科纳
L·高蒂尔
Y·摩尔
O·德马里亚
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Innate Pharma SA
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Innate Pharma SA
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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CN202280032592.8A 2021-03-26 2022-03-24 包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 Pending CN117321087A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163166374P 2021-03-26 2021-03-26
US63/166,374 2021-03-26
PCT/EP2022/057824 WO2022200525A1 (en) 2021-03-26 2022-03-24 Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging

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CN117321087A true CN117321087A (zh) 2023-12-29

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US (1) US20240199750A1 (https=)
EP (1) EP4313312A1 (https=)
JP (1) JP2024511465A (https=)
KR (1) KR20230162013A (https=)
CN (1) CN117321087A (https=)
AU (1) AU2022246048A1 (https=)
BR (1) BR112023019138A2 (https=)
CA (1) CA3207652A1 (https=)
IL (1) IL305847A (https=)
MX (1) MX2023011310A (https=)
WO (1) WO2022200525A1 (https=)

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MX2023007901A (es) 2020-12-31 2023-07-11 Sanofi Sa Acopladores de celulas asesinas naturales (nk) multifuncionales que se unen a nkp46 y a cd123.
IL317227A (en) 2022-05-27 2025-01-01 Sanofi Sa Combined natural killer (NK) cells bind to NKP46 and BCMA variants with FC engineering
AU2023342647A1 (en) * 2022-09-15 2025-02-20 Avidicure Ip B.V. Multispecific antigen binding proteins for tumor-targeting of nk cells and use thereof
WO2024208818A1 (en) 2023-04-04 2024-10-10 Innate Pharma Modular chimeric antigen receptor
WO2024251884A1 (en) 2023-06-09 2024-12-12 Innate Pharma Nk cell engager proteins comprising anti-cd20 and ant-nkp46 antibody, linked to il-2 in treatment of r/r b-nhl

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