CN116334142A - 用于改善移植的crispr/cas相关方法和组合物 - Google Patents
用于改善移植的crispr/cas相关方法和组合物 Download PDFInfo
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- CN116334142A CN116334142A CN202310425192.XA CN202310425192A CN116334142A CN 116334142 A CN116334142 A CN 116334142A CN 202310425192 A CN202310425192 A CN 202310425192A CN 116334142 A CN116334142 A CN 116334142A
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- C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562173321P | 2015-06-09 | 2015-06-09 | |
| US62/173,321 | 2015-06-09 | ||
| US201662294493P | 2016-02-12 | 2016-02-12 | |
| US62/294,493 | 2016-02-12 | ||
| PCT/US2016/036602 WO2016201047A1 (en) | 2015-06-09 | 2016-06-09 | Crispr/cas-related methods and compositions for improving transplantation |
| CN201680046875.2A CN108026526B (zh) | 2015-06-09 | 2016-06-09 | 用于改善移植的crispr/cas相关方法和组合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680046875.2A Division CN108026526B (zh) | 2015-06-09 | 2016-06-09 | 用于改善移植的crispr/cas相关方法和组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116334142A true CN116334142A (zh) | 2023-06-27 |
Family
ID=56236096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310425192.XA Pending CN116334142A (zh) | 2015-06-09 | 2016-06-09 | 用于改善移植的crispr/cas相关方法和组合物 |
| CN201680046875.2A Active CN108026526B (zh) | 2015-06-09 | 2016-06-09 | 用于改善移植的crispr/cas相关方法和组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680046875.2A Active CN108026526B (zh) | 2015-06-09 | 2016-06-09 | 用于改善移植的crispr/cas相关方法和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11911415B2 (enExample) |
| EP (1) | EP3307887A1 (enExample) |
| JP (3) | JP7396783B2 (enExample) |
| KR (1) | KR102796744B1 (enExample) |
| CN (2) | CN116334142A (enExample) |
| AU (2) | AU2016276702B2 (enExample) |
| WO (1) | WO2016201047A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20210137991A1 (en) * | 2013-02-08 | 2021-05-13 | Themba Inc. | Gene editing for autoimmune disorders |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| US11911415B2 (en) | 2015-06-09 | 2024-02-27 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for improving transplantation |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| CA3045667A1 (en) | 2016-12-13 | 2018-06-21 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| CN110869046B (zh) | 2017-03-31 | 2025-02-25 | 塞勒克提斯公司 | 通用型抗cd22嵌合抗原受体工程化的免疫细胞 |
| CA3061614A1 (en) * | 2017-04-28 | 2018-11-01 | The Regents Of The University Of Colorado, A Body Corporate | Methods of treating rheumatoid arthritis using rna-guided genome editing of hla gene |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3638775A1 (en) * | 2017-06-13 | 2020-04-22 | Fate Therapeutics, Inc. | Compositions and methods for inducing myeloid suppressive cells and use thereof |
| JP2020525003A (ja) * | 2017-06-21 | 2020-08-27 | バートナム,ティモシー,エー. | 腎臓病治療のための免疫特権を有する生物活性腎細胞 |
| AU2018292181B2 (en) | 2017-06-30 | 2025-04-10 | Cellectis | Cellular immunotherapy for repetitive administration |
| US11441135B2 (en) | 2017-07-07 | 2022-09-13 | Toolgen Incorporated | Target-specific CRISPR mutant |
| EP3652312A1 (en) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019040655A1 (en) * | 2017-08-22 | 2019-02-28 | The Regents Of The University Of California | LENTIVIRAL VECTORS EXPRESSING FOXP3 IN HEMATOPOIETIC STEM CELLS TO TREAT IMMUNITY DEFICIENCIES AND AUTOIMMUNE DISEASES |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| CA3078963A1 (en) * | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | Anti-cd45-based conditioning methods and uses thereof in conjunction with gene-edited cell-based therapies |
| JP2021502077A (ja) * | 2017-11-06 | 2021-01-28 | エディタス・メディシン,インコーポレイテッド | 免疫療法のためのt細胞におけるcblbのcrispr−cas9編集のための方法、組成物および構成要素 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3754018A4 (en) * | 2018-02-16 | 2021-11-24 | Kyoto University | METHOD OF MANUFACTURING A WEAK ANTIGENT CELL |
| CN110229814B (zh) * | 2018-03-06 | 2025-11-14 | 中国科学院动物研究所 | 改进的向导rna |
| CN108330138B (zh) * | 2018-03-29 | 2018-09-25 | 上海欣百诺生物科技有限公司 | 一种sgRNA的体外合成方法及其试剂盒 |
| CA3091490A1 (en) * | 2018-04-27 | 2019-10-31 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Rapamycin resistant cells |
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| AU2016276702A1 (en) | 2017-12-14 |
| US20240252543A1 (en) | 2024-08-01 |
| CN108026526B (zh) | 2023-05-12 |
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