CN1155603C - 3-头孢烯化合物的制备方法 - Google Patents

3-头孢烯化合物的制备方法 Download PDF

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Publication number
CN1155603C
CN1155603C CNB98809245XA CN98809245A CN1155603C CN 1155603 C CN1155603 C CN 1155603C CN B98809245X A CNB98809245X A CN B98809245XA CN 98809245 A CN98809245 A CN 98809245A CN 1155603 C CN1155603 C CN 1155603C
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CN
China
Prior art keywords
formula
sulfenyl
alkyl group
salt
low alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB98809245XA
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English (en)
Chinese (zh)
Other versions
CN1270594A (zh
Inventor
������ɽ����
龟山丰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
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Otsuka Chemical Co Ltd
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Publication date
Application filed by Otsuka Chemical Co Ltd filed Critical Otsuka Chemical Co Ltd
Publication of CN1270594A publication Critical patent/CN1270594A/zh
Application granted granted Critical
Publication of CN1155603C publication Critical patent/CN1155603C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB98809245XA 1997-10-17 1998-10-16 3-头孢烯化合物的制备方法 Expired - Lifetime CN1155603C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP303765/1997 1997-10-17
JP9303765A JPH11124384A (ja) 1997-10-17 1997-10-17 ３−セフェム化合物の製造法

Publications (2)

Publication Number Publication Date
CN1270594A CN1270594A (zh) 2000-10-18
CN1155603C true CN1155603C (zh) 2004-06-30

Family

ID=17925019

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB98809245XA Expired - Lifetime CN1155603C (zh) 1997-10-17 1998-10-16 3-头孢烯化合物的制备方法

Country Status (9)

Country Link
US (1) US6448393B1 (ko)
EP (2) EP1028118B1 (ko)
JP (1) JPH11124384A (ko)
KR (1) KR100420739B1 (ko)
CN (1) CN1155603C (ko)
AT (2) ATE554094T1 (ko)
AU (1) AU9462298A (ko)
ES (2) ES2382546T3 (ko)
WO (1) WO1999020631A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101792453A (zh) * 2010-03-17 2010-08-04 河北九派制药有限公司 一种7-氨基-3-磺酸基四氮唑硫甲基头孢烷酸的制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4383557B2 (ja) * 1998-07-01 2009-12-16 大塚化学株式会社 ３−セフェム化合物の製造方法
WO2007013043A2 (en) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid
CN102633813A (zh) * 2012-04-17 2012-08-15 黑龙江豪运精细化工有限公司 一种头孢唑林钠中间体tda的制备方法
CN104910188B (zh) * 2015-05-26 2017-07-04 齐鲁安替制药有限公司 一种头孢唑林酸的合成方法
CN105131018B (zh) * 2015-09-23 2017-12-26 浙江华方药业股份有限公司 一种头孢替唑酸的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
JP2501785B2 (ja) * 1984-07-09 1996-05-29 明治製菓株式会社 新規セフアロスポリン系化合物
AU5258786A (en) * 1985-01-31 1986-08-07 Yamanouchi Pharmaceutical Co., Ltd. 3-pyridinio thio methyl cephalosporins
JPH064638B2 (ja) * 1985-05-17 1994-01-19 大塚化学株式会社 β−ラクタム誘導体の製造方法
US5070194A (en) * 1985-05-17 1991-12-03 Otsuka Kagaku Kabushiki Kaisha Method for production of β-lactam derivatives
JPH064645B2 (ja) * 1985-11-27 1994-01-19 明治製菓株式会社 新規セフアロスポリン誘導体およびそれを含む抗菌剤
CA1283404C (en) * 1986-07-01 1991-04-23 Shigeru Sanai Cephalosporin compounds, processes for their preparation and antibacterial agents
GB8616002D0 (en) * 1986-07-01 1986-08-06 Fujisawa Pharmaceutical Co Cephem compounds
JPH0651706B2 (ja) * 1986-08-18 1994-07-06 科研製薬株式会社 新規なセファロスポリン化合物
EP0416814B1 (en) * 1989-09-04 2002-04-24 Pfizer Inc. Antibacterial cephalosporin derivatives
GB9006728D0 (en) * 1990-03-26 1990-05-23 Beecham Group Plc Novel compounds
GB9104238D0 (en) * 1990-03-16 1991-04-17 Ici Pharma 3-tetrazolylthiomethyl cephalosporin antibiotics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101792453A (zh) * 2010-03-17 2010-08-04 河北九派制药有限公司 一种7-氨基-3-磺酸基四氮唑硫甲基头孢烷酸的制备方法
CN101792453B (zh) * 2010-03-17 2012-04-18 河北九派制药有限公司 一种7-氨基-3-磺酸基四氮唑硫甲基头孢烷酸的制备方法

Also Published As

Publication number Publication date
EP1512689B1 (en) 2012-04-18
EP1512689A1 (en) 2005-03-09
ATE554094T1 (de) 2012-05-15
KR20010031117A (ko) 2001-04-16
JPH11124384A (ja) 1999-05-11
AU9462298A (en) 1999-05-10
EP1028118A1 (en) 2000-08-16
KR100420739B1 (ko) 2004-03-02
ES2382546T3 (es) 2012-06-11
US6448393B1 (en) 2002-09-10
EP1028118A4 (en) 2003-01-22
ES2310011T3 (es) 2008-12-16
WO1999020631A1 (fr) 1999-04-29
EP1028118B1 (en) 2008-07-30
CN1270594A (zh) 2000-10-18
ATE402940T1 (de) 2008-08-15

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Granted publication date: 20040630