CN114901311A - Tnf样配体1a（tl1a）的人源化抗体及其用途 - Google Patents

Tnf样配体1a（tl1a）的人源化抗体及其用途 Download PDF

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Publication number
CN114901311A
CN114901311A CN202080090377.4A CN202080090377A CN114901311A CN 114901311 A CN114901311 A CN 114901311A CN 202080090377 A CN202080090377 A CN 202080090377A CN 114901311 A CN114901311 A CN 114901311A
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antibody
seq
amino acid
region
chain variable
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Chinese (zh)
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杰弗里·D·沃特金斯
辛迪·T·迪克森
拉法尔·罗贾斯
马修·里斯曼
帕特丽夏·麦克内利
J·比尔斯伯勒
布拉德利·亨克尔
S·R·塔尔干
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Cedars Sinai Medical Center
Prometheus Biosciences Inc
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Cedars Sinai Medical Center
Prometheus Biosciences Inc
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Priority to CN202211312304.2A priority Critical patent/CN116063517A/zh
Priority claimed from PCT/US2020/057119 external-priority patent/WO2021081365A1/en
Publication of CN114901311A publication Critical patent/CN114901311A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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CN202080090377.4A 2019-10-24 2020-10-23 Tnf样配体1a（tl1a）的人源化抗体及其用途 Pending CN114901311A (zh)

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US201962925736P 2019-10-24 2019-10-24
US62/925,736 2019-10-24
PCT/US2020/057119 WO2021081365A1 (en) 2019-10-24 2020-10-23 Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof

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US (3) US11292848B2 (https=)
EP (1) EP4048309A4 (https=)
JP (3) JP7504992B2 (https=)
KR (1) KR20220103721A (https=)
CN (2) CN114901311A (https=)
AU (1) AU2020371725A1 (https=)
BR (1) BR112022007720A2 (https=)
CA (1) CA3158638A1 (https=)
CO (1) CO2022006679A2 (https=)
IL (1) IL292419A (https=)
MX (1) MX2022004942A (https=)
NZ (1) NZ787680A (https=)
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Cited By (2)

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WO2025185773A1 (zh) * 2024-03-05 2025-09-12 帆礼生物技术(武汉)有限公司 靶向tl1a的抗体及其应用
WO2026056853A1 (zh) * 2024-09-10 2026-03-19 先声药业有限公司 Tl1a抗体及其应用

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JP7332627B2 (ja) 2018-04-25 2023-08-23 プロメテウス バイオサイエンシーズ，インク． 最適化された抗ｔｌ１ａ抗体
WO2020112890A1 (en) 2018-11-29 2020-06-04 Cedars-Sinai Medical Center Rnaset2 compositions and methods of treatment therewith
JP2022533956A (ja) 2019-05-14 2022-07-27 プロメテウス バイオサイエンシーズ，インク． Ｔｌ１ａ患者を選択する方法、システム、およびデバイス
KR20220103721A (ko) * 2019-10-24 2022-07-22 프로메테우스 바이오사이언시즈, 인크. Tnf 유사 리간드 1a(tl1a)에 대한 인간화 항체 및 그의 용도
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CA3207818A1 (en) * 2021-02-18 2022-08-25 Allison LUO Anti-tl1a antibody compositions and methods of treatment in the lung
US20240400671A1 (en) * 2021-10-05 2024-12-05 Richard A. Shimkets Monoconal antibodies to il-25 and uses thereof
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TW202535949A (zh) 2023-12-20 2025-09-16 美商必治妥美雅史谷比公司 靶向IL-18受體β(IL-18RB)之抗體及相關方法
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CN120818053A (zh) * 2024-04-11 2025-10-21 北京伟德杰生物科技有限公司 Tl1a抗体及其应用
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WO2026056853A1 (zh) * 2024-09-10 2026-03-19 先声药业有限公司 Tl1a抗体及其应用

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