CN1146567C - 奥氮平二水合物d - Google Patents

奥氮平二水合物d Download PDF

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Publication number
CN1146567C
CN1146567C CNB971981213A CN97198121A CN1146567C CN 1146567 C CN1146567 C CN 1146567C CN B971981213 A CNB971981213 A CN B971981213A CN 97198121 A CN97198121 A CN 97198121A CN 1146567 C CN1146567 C CN 1146567C
Authority
CN
China
Prior art keywords
dihydrate
olanzapine
preparation
ray powder
polymorphic form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB971981213A
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English (en)
Chinese (zh)
Other versions
CN1234738A (zh
Inventor
S��D���ܿ�ɭ
S·D·拉森
ƶ��׿�
J·R·尼科尔斯
S·M·雷乌特泽
˹�ٷ�ɭ
G·A·斯蒂芬森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832112&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1146567(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1234738A publication Critical patent/CN1234738A/zh
Application granted granted Critical
Publication of CN1146567C publication Critical patent/CN1146567C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB971981213A 1996-09-23 1997-09-18 奥氮平二水合物d Expired - Fee Related CN1146567C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2648696P 1996-09-23 1996-09-23
US60/026,486 1996-09-23

Publications (2)

Publication Number Publication Date
CN1234738A CN1234738A (zh) 1999-11-10
CN1146567C true CN1146567C (zh) 2004-04-21

Family

ID=21832112

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB971981213A Expired - Fee Related CN1146567C (zh) 1996-09-23 1997-09-18 奥氮平二水合物d

Country Status (34)

Country Link
US (1) US6251895B1 (enExample)
EP (1) EP0831097B1 (enExample)
JP (1) JP2001500878A (enExample)
KR (1) KR100516088B1 (enExample)
CN (1) CN1146567C (enExample)
AR (1) AR009801A1 (enExample)
AT (1) ATE221074T1 (enExample)
AU (1) AU720366B2 (enExample)
BR (1) BR9711541A (enExample)
CA (1) CA2266444C (enExample)
CO (1) CO4900057A1 (enExample)
CZ (1) CZ299247B6 (enExample)
DE (1) DE69714165T2 (enExample)
DK (1) DK0831097T3 (enExample)
EA (1) EA001881B1 (enExample)
EG (1) EG23815A (enExample)
ES (1) ES2180899T3 (enExample)
HU (1) HU226167B1 (enExample)
ID (1) ID21924A (enExample)
IL (1) IL128956A0 (enExample)
MY (1) MY125467A (enExample)
NO (1) NO323979B1 (enExample)
NZ (1) NZ334346A (enExample)
PE (1) PE110298A1 (enExample)
PL (1) PL194074B1 (enExample)
PT (1) PT831097E (enExample)
RS (1) RS49597B (enExample)
SI (1) SI0831097T1 (enExample)
SV (1) SV1997000079A (enExample)
TR (1) TR199900639T2 (enExample)
TW (1) TW518335B (enExample)
UA (1) UA56184C2 (enExample)
WO (1) WO1998011893A1 (enExample)
ZA (1) ZA978512B (enExample)

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AU759751B2 (en) * 1998-09-30 2003-05-01 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
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EP1246827B1 (en) * 1999-12-28 2005-04-13 Cipla Limited New polymorphic forms of olanzapine
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US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
EP1440074A1 (en) * 2001-10-29 2004-07-28 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
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US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
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US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US20070148218A1 (en) * 2003-11-18 2007-06-28 Gordon Ryan D Olanzapine containing transdermal drug delivery compositions
EP1709053B1 (en) 2004-01-27 2011-04-06 Synthon B.V. Stable salts of olanzapine
DE102004029784A1 (de) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004030502A1 (de) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
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DE05783995T1 (de) * 2004-07-14 2007-10-11 Shasun Chemicals and Drugs Ltd., Chennai Verbessertes verfahren zur herstellung von form i aus olanzapin
US7759485B2 (en) 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060035903A1 (en) 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
US20060074088A1 (en) 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
EP1630163A1 (de) 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
WO2006027800A1 (en) * 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited A novel process for preparation of a pharmaceutically pure polymorphic form 1 of olanzapine
US8877933B2 (en) 2004-09-29 2014-11-04 Bayer Intellectual Property Gmbh Thermodynamically stable form of a tosylate salt
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
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DK1838716T3 (da) 2005-01-05 2011-07-25 Lilly Co Eli Olanzapinpamota-dihydrat
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EA030606B1 (ru) 2006-05-04 2018-08-31 Бёрингер Ингельхайм Интернациональ Гмбх Способы приготовления лекарственного средства, содержащего полиморфы
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
US8039461B1 (en) 2006-11-10 2011-10-18 Pisgah Laboratories, Inc. Physical states of a pharmaceutical drug substance
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JP2016027003A (ja) * 2012-11-20 2016-02-18 大蔵製薬株式会社 長期間安定なオランザピンの水性医薬製剤
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
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EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine

Also Published As

Publication number Publication date
CA2266444A1 (en) 1998-03-26
DE69714165D1 (de) 2002-08-29
KR100516088B1 (ko) 2005-09-22
ZA978512B (en) 1999-03-23
JP2001500878A (ja) 2001-01-23
EA001881B1 (ru) 2001-10-22
PL194074B1 (pl) 2007-04-30
AR009801A1 (es) 2000-05-03
US6251895B1 (en) 2001-06-26
EP0831097A3 (en) 1998-04-29
NO991339D0 (no) 1999-03-19
PL332541A1 (en) 1999-09-13
EG23815A (en) 2007-08-19
CZ299247B6 (cs) 2008-05-28
WO1998011893A1 (en) 1998-03-26
PE110298A1 (es) 1999-01-18
EA199900325A1 (ru) 1999-08-26
PT831097E (pt) 2002-10-31
TR199900639T2 (xx) 1999-06-21
BR9711541A (pt) 1999-08-24
CZ98999A3 (cs) 1999-08-11
TW518335B (en) 2003-01-21
DE69714165T2 (de) 2003-01-23
CN1234738A (zh) 1999-11-10
HUP0000065A2 (hu) 2000-06-28
HK1009809A1 (en) 1999-06-11
ID21924A (id) 1999-08-12
UA56184C2 (uk) 2003-05-15
NO323979B1 (no) 2007-07-30
AU4424197A (en) 1998-04-14
ES2180899T3 (es) 2003-02-16
CA2266444C (en) 2007-01-09
AU720366B2 (en) 2000-06-01
ATE221074T1 (de) 2002-08-15
DK0831097T3 (da) 2002-09-02
NO991339L (no) 1999-03-19
RS49597B (sr) 2007-06-04
EP0831097A2 (en) 1998-03-25
YU15499A (sh) 2000-03-21
HU226167B1 (hu) 2008-05-28
NZ334346A (en) 2000-05-26
CO4900057A1 (es) 2000-03-27
MY125467A (en) 2006-08-30
HUP0000065A3 (en) 2000-11-28
EP0831097B1 (en) 2002-07-24
SV1997000079A (es) 1999-01-13
SI0831097T1 (en) 2003-02-28
KR20000048519A (ko) 2000-07-25
IL128956A0 (en) 2000-02-17

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