CN114133448A - 新型pd-1免疫调节剂 - Google Patents
新型pd-1免疫调节剂 Download PDFInfo
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- CN114133448A CN114133448A CN202111160281.3A CN202111160281A CN114133448A CN 114133448 A CN114133448 A CN 114133448A CN 202111160281 A CN202111160281 A CN 202111160281A CN 114133448 A CN114133448 A CN 114133448A
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Families Citing this family (53)
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| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
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| WO2017011580A2 (en) | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| HK1257840A1 (zh) | 2015-09-01 | 2019-11-01 | Agenus Inc. | 抗-pd-1抗体及其使用方法 |
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| MA43186B1 (fr) | 2015-11-03 | 2022-03-31 | Janssen Biotech Inc | Anticorps se liant spécifiquement à pd-1 et leurs utilisations |
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| EP3443001B1 (en) | 2016-04-11 | 2025-04-30 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
| BR112019004733A2 (pt) | 2016-09-19 | 2019-05-28 | Celgene Corp | métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1 |
| US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2017373945B2 (en) | 2016-12-07 | 2025-01-23 | Agenus Inc. | Antibodies and methods of use thereof |
| EP3557671A4 (en) * | 2016-12-19 | 2020-08-19 | Showa Denko K.K. | PROCEDURE FOR OPERATING A REDOX FLOW BATTERY |
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| IL268620B2 (en) * | 2017-04-05 | 2024-04-01 | Hoffmann La Roche | Antibodies against LAG3 pharmaceutical formulations containing them, and their uses for cancer treatment |
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| EP3612222A4 (en) * | 2017-04-19 | 2020-12-23 | University of Southern California | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス, インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| CN110809582B (zh) * | 2017-05-01 | 2023-12-22 | 儿童医疗中心有限公司 | 涉及抗pd1抗体试剂的方法以及组合物 |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| KR20200037250A (ko) * | 2017-07-06 | 2020-04-08 | 메뤼스 엔.페. | 세포에 의해 발현되는 생물학적 활성을 조절하는 항체 |
| WO2019018727A1 (en) * | 2017-07-21 | 2019-01-24 | Washington University | METHODS AND COMPOSITIONS FOR T-CELL ACTIVATION |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| KR20200128014A (ko) * | 2018-01-31 | 2020-11-11 | 셀진 코포레이션 | 입양 세포 요법 및 체크포인트 억제제를 이용한 병용 요법 |
| CN112041432A (zh) | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
| KR20210011919A (ko) | 2018-04-17 | 2021-02-02 | 셀덱스 쎄라퓨틱스, 인크. | 항-cd27 항체 및 항-pd-l1 항체 및 이중특이적 작제물 |
| EA202190181A1 (ru) * | 2018-07-04 | 2021-05-27 | Сайтоиммьюн Терапьютикс, Инк. | Композиции и способы для направленной иммунотерапии flt3, pd-1 и/или pd-l1 |
| EP3876958A1 (en) | 2018-11-08 | 2021-09-15 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| CN111320690B (zh) * | 2018-12-17 | 2022-04-05 | 程联胜 | 一种抗人Tim3单克隆抗体及其应用 |
| CN111748580B (zh) * | 2019-03-28 | 2022-09-13 | 百奥泰生物制药股份有限公司 | 一种检测免疫检查点抗体活性的方法 |
| CN111892655B (zh) * | 2019-05-06 | 2022-10-28 | 四川大学 | 抗pd-1纳米抗体的筛选及应用 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| JP7680967B2 (ja) * | 2019-06-14 | 2025-05-21 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Pd-1に対する抗体およびその使用方法 |
| TWI809286B (zh) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| EP3996735A4 (en) | 2019-07-12 | 2023-07-19 | The Research Foundation for The State University of New York | COMPOSITIONS AND METHODS FOR BLOCKING AND BINDING CXCR4 TO MODULATE CELLULAR FUNCTION |
| US20220332825A1 (en) | 2019-08-08 | 2022-10-20 | Ono Pharmaceutical Co., Ltd. | Bispecific protein |
| CA3147837A1 (en) * | 2019-08-16 | 2021-02-25 | Marco Davila | Anti-cd83 chimeric antigen receptor expressing t regulatory cells |
| CN112852740A (zh) * | 2019-11-27 | 2021-05-28 | 深圳市菲鹏生物治疗股份有限公司 | Car-t细胞和检测方法 |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| MX2022014974A (es) | 2020-05-26 | 2023-01-11 | Boehringer Ingelheim Int | Anticuerpos anti-pd-1. |
| CN114437229B (zh) * | 2020-11-01 | 2024-03-12 | 复旦大学 | 携带pd-1単链抗体且靶向egfr抗原的car t免疫细胞的制备及其用途 |
| CN112812174A (zh) * | 2021-01-15 | 2021-05-18 | 新乡学院 | 猪pd-l14qn-af表位多肽及其应用 |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| WO2024182754A2 (en) * | 2023-03-02 | 2024-09-06 | Fred Hutchinson Cancer Center | Anti-pd-1 chimeric antigen receptor t cells and therapeutic uses thereof |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025085538A1 (en) * | 2023-10-17 | 2025-04-24 | Lanier Biotherapeutics, Inc. | Alarmin binding molecules and treatment of cancer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056875A1 (en) * | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| CN103242448A (zh) * | 2013-05-27 | 2013-08-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
| CN103965363A (zh) * | 2013-02-06 | 2014-08-06 | 上海白泽生物科技有限公司 | 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途 |
| CN104479020A (zh) * | 2014-12-26 | 2015-04-01 | 上海复宏汉霖生物技术有限公司 | 一种抗pd-1人源抗体 |
| CN104558177A (zh) * | 2013-10-25 | 2015-04-29 | 苏州思坦维生物技术有限责任公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4834976A (en) * | 1986-07-03 | 1989-05-30 | Genetic Systems Corporation | Monoclonal antibodies to pseudomonas aeruginosa flagella |
| EP1896582A4 (en) * | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| PT2520590T (pt) * | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| WO2008156712A1 (en) * | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| EA201490364A1 (ru) * | 2011-07-29 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Костимулирующие рецепторы-переключатели |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| EP3811954A1 (en) * | 2013-02-26 | 2021-04-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| MY192062A (en) * | 2014-12-05 | 2022-07-25 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof |
| WO2016191246A2 (en) * | 2015-05-22 | 2016-12-01 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for a prame peptide |
| KR20180019725A (ko) * | 2015-06-23 | 2018-02-26 | 메모리얼 슬로안-케터링 캔서 센터 | 신규의 피디 1 면역 조절제 |
| IL259747B (en) * | 2015-12-04 | 2022-09-01 | Memorial Sloan Kettering Cancer Center | Antibodies targeting fc receptor-like 5 and methods of use |
| JP7022067B2 (ja) * | 2016-01-14 | 2022-02-17 | メモリアル スローン ケタリング キャンサー センター | Foxp3由来のペプチドに特異的なt細胞受容体様抗体 |
| SI3535298T1 (sl) * | 2016-11-02 | 2022-01-31 | Jounce Therapeutics, Inc. | Protitelesa proti pd-1 in njihove uporabe |
| AU2018339528A1 (en) * | 2017-09-26 | 2020-04-16 | Longwood University | PD1-specific chimeric antigen receptor as an immunotherapy |
-
2016
- 2016-06-23 KR KR1020187002014A patent/KR20180019725A/ko not_active Withdrawn
- 2016-06-23 HK HK18113888.8A patent/HK1254803A1/zh unknown
- 2016-06-23 TW TW105119709A patent/TWI773647B/zh not_active IP Right Cessation
- 2016-06-23 WO PCT/US2016/039015 patent/WO2016210129A1/en not_active Ceased
- 2016-06-23 AU AU2016281641A patent/AU2016281641B2/en active Active
- 2016-06-23 CN CN202111160281.3A patent/CN114133448A/zh active Pending
- 2016-06-23 EP EP16736667.3A patent/EP3313883B1/en active Active
- 2016-06-23 CN CN201680037151.1A patent/CN108337890B/zh active Active
- 2016-06-23 JP JP2018519261A patent/JP6974311B2/ja active Active
- 2016-06-23 CA CA3006224A patent/CA3006224A1/en not_active Abandoned
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- 2017-12-20 IL IL256463A patent/IL256463A/en unknown
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056875A1 (en) * | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| CN103965363A (zh) * | 2013-02-06 | 2014-08-06 | 上海白泽生物科技有限公司 | 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途 |
| CN103242448A (zh) * | 2013-05-27 | 2013-08-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
| CN104558177A (zh) * | 2013-10-25 | 2015-04-29 | 苏州思坦维生物技术有限责任公司 | 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途 |
| CN104479020A (zh) * | 2014-12-26 | 2015-04-01 | 上海复宏汉霖生物技术有限公司 | 一种抗pd-1人源抗体 |
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| Publication number | Publication date |
|---|---|
| JP6974311B2 (ja) | 2021-12-01 |
| KR20180019725A (ko) | 2018-02-26 |
| EP3313883B1 (en) | 2023-12-06 |
| CA3006224A1 (en) | 2016-12-29 |
| HK1254803A1 (zh) | 2019-07-26 |
| US11136392B2 (en) | 2021-10-05 |
| JP2018518540A (ja) | 2018-07-12 |
| TW201718648A (zh) | 2017-06-01 |
| CN108337890B (zh) | 2021-10-15 |
| JP2021177768A (ja) | 2021-11-18 |
| AU2016281641B2 (en) | 2022-01-20 |
| TWI773647B (zh) | 2022-08-11 |
| IL256463A (en) | 2018-02-28 |
| WO2016210129A1 (en) | 2016-12-29 |
| CN108337890A (zh) | 2018-07-27 |
| AU2016281641A1 (en) | 2018-02-08 |
| US20180127502A1 (en) | 2018-05-10 |
| EP3313883A1 (en) | 2018-05-02 |
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