CN1138765C - 带有硫代羰基功能基的噁唑烷酮抗菌剂 - Google Patents
带有硫代羰基功能基的噁唑烷酮抗菌剂 Download PDFInfo
- Publication number
- CN1138765C CN1138765C CNB98805423XA CN98805423A CN1138765C CN 1138765 C CN1138765 C CN 1138765C CN B98805423X A CNB98805423X A CN B98805423XA CN 98805423 A CN98805423 A CN 98805423A CN 1138765 C CN1138765 C CN 1138765C
- Authority
- CN
- China
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- methyl
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4834297P | 1997-05-30 | 1997-05-30 | |
| US60/048,342 | 1997-05-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1257486A CN1257486A (zh) | 2000-06-21 |
| CN1138765C true CN1138765C (zh) | 2004-02-18 |
Family
ID=21954059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB98805423XA Expired - Fee Related CN1138765C (zh) | 1997-05-30 | 1998-05-18 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6218413B1 (enExample) |
| EP (1) | EP0984947B8 (enExample) |
| JP (1) | JP2002501530A (enExample) |
| KR (1) | KR20010013192A (enExample) |
| CN (1) | CN1138765C (enExample) |
| AT (1) | ATE293609T1 (enExample) |
| AU (1) | AU737995B2 (enExample) |
| BR (1) | BR9815518A (enExample) |
| CA (1) | CA2288750A1 (enExample) |
| DE (1) | DE69829846T2 (enExample) |
| ES (1) | ES2242280T3 (enExample) |
| FI (1) | FI19992555L (enExample) |
| HU (1) | HUP0001393A3 (enExample) |
| NO (1) | NO315798B1 (enExample) |
| NZ (1) | NZ501412A (enExample) |
| PL (1) | PL337329A1 (enExample) |
| RU (1) | RU2208613C2 (enExample) |
| SK (1) | SK156499A3 (enExample) |
| WO (1) | WO1998054161A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2228647A1 (en) * | 1995-09-01 | 1997-03-13 | Pharmacia & Upjohn Company | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| DK1054874T3 (da) * | 1998-02-13 | 2002-12-30 | Upjohn Co | Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler |
| AU3180999A (en) * | 1998-02-25 | 1999-09-15 | Pharmacia & Upjohn Company | Substituted aminomethyl isoxazoline derivatives useful as antimicrobials |
| SK18362000A3 (sk) | 1998-06-05 | 2001-06-11 | Astrazeneca Ab | Oxazolidinónové deriváty, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| WO2000029396A1 (de) * | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue substituierte phenyloxazolidon-derivate |
| WO2000029409A1 (de) * | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue heterocyclyl-substituierte oxazolidon-derivate |
| JP2002531455A (ja) * | 1998-11-27 | 2002-09-24 | ファルマシア・アンド・アップジョン・カンパニー | チオカルボニル官能基を有するオキサゾリジノン抗細菌剤 |
| EP1200416A1 (en) | 1999-07-28 | 2002-05-02 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
| US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| MY120189A (en) | 1999-11-04 | 2005-09-30 | Upjohn Co | Sultam and sultone derived oxazolidinones |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| EP1242417A1 (en) * | 1999-12-21 | 2002-09-25 | PHARMACIA & UPJOHN COMPANY | Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| CN1395569A (zh) * | 2000-02-10 | 2003-02-05 | 法玛西雅厄普约翰美国公司 | 含有哌嗪酰胺取代基的噁唑二酮硫代酰胺 |
| US6642238B2 (en) * | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
| AU2001253113B2 (en) * | 2000-04-20 | 2005-02-03 | Pharmacia & Upjohn Company | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6562820B2 (en) | 2000-07-05 | 2003-05-13 | Pharmacia & Upjohn Company | Method for treatment and prevention of mastitis |
| CZ2003228A3 (cs) * | 2000-07-17 | 2003-06-18 | Ranbaxy Laboratories Limited | Oxazolidinonové deriváty jako antimikrobiální látky |
| PE20020689A1 (es) | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| CA2405532A1 (en) | 2001-02-07 | 2002-08-22 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods |
| WO2002081470A1 (en) * | 2001-04-07 | 2002-10-17 | Astrazeneca Ab | Oxazolidinones containing a sulfonimid group as antibiotics |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| AU2002319848A1 (en) * | 2002-07-29 | 2004-02-25 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US7094900B2 (en) | 2002-08-12 | 2006-08-22 | Pharmacia & Upjohn Company Llc | N-Aryl-2-oxazolidinones and their derivatives |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2003265090A1 (en) | 2002-10-10 | 2004-05-04 | Pharmacia & Upjohn Comapny LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| BRPI0409217A (pt) | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
| MXPA05013132A (es) | 2003-06-03 | 2006-05-25 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo y metodos de produccion y su uso. |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| WO2005019214A1 (en) * | 2003-08-25 | 2005-03-03 | Warner-Lambert Company Llc | Novel antimicrobial aryloxazolidinone compounds |
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) * | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| US7592335B2 (en) | 2005-04-15 | 2009-09-22 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| US8399660B2 (en) | 2005-06-08 | 2013-03-19 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| RU2578602C2 (ru) | 2005-10-04 | 2016-03-27 | Байер Интеллектуэль Проперти Гмбх | Способ получения 5-хлор-n-(5s)-2-оксо-3-[4-(3-оксо-морфолинил)-фенил]-1,3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида в модификации ii (варианты) |
| US8148362B2 (en) * | 2006-03-31 | 2012-04-03 | Research Foundation Itsuu Laboratory | Compound having heterocyclic ring |
| WO2009001192A2 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
| WO2009044777A1 (ja) | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| EP2655362A1 (en) | 2010-12-22 | 2013-10-30 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
| US9233989B2 (en) * | 2011-10-11 | 2016-01-12 | Council Of Scientific & Industrial Research | Sila analogs of oxazolidinone derivatives and synthesis thereof |
| CN103360294B (zh) * | 2012-03-28 | 2015-11-25 | 复旦大学 | 具有抗结核活性的化合物及其制备方法和应用 |
| CN103044341B (zh) * | 2012-12-20 | 2015-07-01 | 郑州大学 | 1,2,3-三唑-氨基二硫代甲酸酯-脲复合体、其制备方法及其应用 |
| CA2922567A1 (en) * | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5]decane derivatives and use thereof |
| CN108299329A (zh) * | 2018-03-28 | 2018-07-20 | 许传森 | 一种噁唑酮类衍生物及其在抗菌药物中的应用 |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| CN115466253B (zh) * | 2021-06-16 | 2024-08-20 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8506659A1 (es) | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
| US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| EP0609905B1 (en) * | 1988-09-15 | 2001-06-06 | PHARMACIA & UPJOHN COMPANY | 3-(Nitrogen substituted)phenyl-5beta-amidomethyloxazolidin-2-ones |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| CA2228647A1 (en) * | 1995-09-01 | 1997-03-13 | Pharmacia & Upjohn Company | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| ES2186916T3 (es) | 1996-08-21 | 2003-05-16 | Upjohn Co | Derivados de isoxazolina como agentes antimicrobianos. |
-
1998
- 1998-05-18 NZ NZ501412A patent/NZ501412A/en unknown
- 1998-05-18 SK SK1564-99A patent/SK156499A3/sk unknown
- 1998-05-18 CN CNB98805423XA patent/CN1138765C/zh not_active Expired - Fee Related
- 1998-05-18 AU AU74883/98A patent/AU737995B2/en not_active Ceased
- 1998-05-18 HU HU0001393A patent/HUP0001393A3/hu unknown
- 1998-05-18 CA CA002288750A patent/CA2288750A1/en not_active Abandoned
- 1998-05-18 BR BR9815518-0A patent/BR9815518A/pt not_active Application Discontinuation
- 1998-05-18 JP JP50072299A patent/JP2002501530A/ja not_active Withdrawn
- 1998-05-18 DE DE69829846T patent/DE69829846T2/de not_active Expired - Fee Related
- 1998-05-18 FI FI992555A patent/FI19992555L/fi not_active IP Right Cessation
- 1998-05-18 AT AT98922303T patent/ATE293609T1/de not_active IP Right Cessation
- 1998-05-18 WO PCT/US1998/009889 patent/WO1998054161A1/en not_active Ceased
- 1998-05-18 EP EP98922303A patent/EP0984947B8/en not_active Expired - Lifetime
- 1998-05-18 US US09/080,751 patent/US6218413B1/en not_active Expired - Fee Related
- 1998-05-18 RU RU99128083/04A patent/RU2208613C2/ru not_active IP Right Cessation
- 1998-05-18 PL PL98337329A patent/PL337329A1/xx unknown
- 1998-05-18 KR KR19997011178A patent/KR20010013192A/ko not_active Abandoned
- 1998-05-18 ES ES98922303T patent/ES2242280T3/es not_active Expired - Lifetime
-
1999
- 1999-11-29 NO NO19995846A patent/NO315798B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7488398A (en) | 1998-12-30 |
| NO995846L (no) | 2000-01-28 |
| JP2002501530A (ja) | 2002-01-15 |
| EP0984947B1 (en) | 2005-04-20 |
| NO995846D0 (no) | 1999-11-29 |
| US6218413B1 (en) | 2001-04-17 |
| WO1998054161A1 (en) | 1998-12-03 |
| AU737995B2 (en) | 2001-09-06 |
| NO315798B1 (no) | 2003-10-27 |
| HUP0001393A2 (hu) | 2001-06-28 |
| EP0984947A1 (en) | 2000-03-15 |
| PL337329A1 (en) | 2000-08-14 |
| CA2288750A1 (en) | 1998-12-03 |
| EP0984947B8 (en) | 2005-06-15 |
| DE69829846D1 (de) | 2005-05-25 |
| NZ501412A (en) | 2001-11-30 |
| ATE293609T1 (de) | 2005-05-15 |
| HUP0001393A3 (en) | 2001-07-30 |
| DE69829846T2 (de) | 2006-02-23 |
| FI19992555A7 (fi) | 1999-11-30 |
| HK1027569A1 (en) | 2001-01-19 |
| RU2208613C2 (ru) | 2003-07-20 |
| BR9815518A (pt) | 2000-11-21 |
| ES2242280T3 (es) | 2005-11-01 |
| SK156499A3 (en) | 2000-06-12 |
| CN1257486A (zh) | 2000-06-21 |
| KR20010013192A (ko) | 2001-02-26 |
| WO1998054161A9 (en) | 1999-04-08 |
| FI19992555L (fi) | 1999-11-30 |
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