CN1138532C - 药用气溶胶组合物 - Google Patents

药用气溶胶组合物 Download PDF

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Publication number
CN1138532C
CN1138532C CNB988008300A CN98800830A CN1138532C CN 1138532 C CN1138532 C CN 1138532C CN B988008300 A CNB988008300 A CN B988008300A CN 98800830 A CN98800830 A CN 98800830A CN 1138532 C CN1138532 C CN 1138532C
Authority
CN
China
Prior art keywords
composition
low volatility
aerosol
mmad
hfa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB988008300A
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English (en)
Chinese (zh)
Other versions
CN1229355A (zh
Inventor
D��������
D·莱维斯
D·甘德堂
B·米金
P·温图拉
��������ķ������
G·布拉姆比拉
R·加尔兹亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10814179&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1138532(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of CN1229355A publication Critical patent/CN1229355A/zh
Application granted granted Critical
Publication of CN1138532C publication Critical patent/CN1138532C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB988008300A 1997-06-13 1998-06-10 药用气溶胶组合物 Expired - Lifetime CN1138532C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9712434A GB2326334A (en) 1997-06-13 1997-06-13 Pharmaceutical aerosol compositions
GB9712434.1 1997-06-13

Publications (2)

Publication Number Publication Date
CN1229355A CN1229355A (zh) 1999-09-22
CN1138532C true CN1138532C (zh) 2004-02-18

Family

ID=10814179

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988008300A Expired - Lifetime CN1138532C (zh) 1997-06-13 1998-06-10 药用气溶胶组合物

Country Status (44)

Country Link
EP (2) EP0920302B2 (enExample)
JP (1) JP4380802B2 (enExample)
KR (1) KR100546239B1 (enExample)
CN (1) CN1138532C (enExample)
AR (1) AR012977A1 (enExample)
AT (1) ATE222751T1 (enExample)
AU (1) AU729966B2 (enExample)
BG (1) BG63906B1 (enExample)
BR (1) BR9805993B1 (enExample)
CA (1) CA2263445C (enExample)
CO (1) CO4940408A1 (enExample)
CZ (1) CZ295521B6 (enExample)
DE (1) DE69807420T3 (enExample)
DK (1) DK0920302T4 (enExample)
DZ (1) DZ2516A1 (enExample)
EA (1) EA001259B1 (enExample)
EE (1) EE03664B1 (enExample)
ES (1) ES2182351T5 (enExample)
GB (1) GB2326334A (enExample)
GE (1) GEP20012462B (enExample)
HR (1) HRP980317B1 (enExample)
HU (1) HU228487B1 (enExample)
ID (1) ID21491A (enExample)
IL (1) IL128484A (enExample)
IN (1) IN189317B (enExample)
IS (1) IS2435B (enExample)
IT (1) IT1293803B1 (enExample)
MA (1) MA26507A1 (enExample)
ME (2) MEP44008A (enExample)
MY (1) MY119074A (enExample)
NO (1) NO327775B1 (enExample)
NZ (1) NZ334149A (enExample)
PL (1) PL193721B1 (enExample)
PT (1) PT920302E (enExample)
RS (1) RS51274B (enExample)
SA (1) SA98190821B1 (enExample)
SI (1) SI0920302T2 (enExample)
SK (1) SK284430B8 (enExample)
TN (1) TNSN98087A1 (enExample)
TR (1) TR199900288T1 (enExample)
TW (1) TW555570B (enExample)
UA (1) UA70289C2 (enExample)
WO (1) WO1998056349A1 (enExample)
ZA (1) ZA985136B (enExample)

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IT1303788B1 (it) * 1998-11-25 2001-02-23 Chiesi Farma Spa Formulazioni di aerosol medicinali.
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
FR2798290B1 (fr) 1999-09-11 2003-09-12 Glaxo Group Ltd Formulation pharmaceutique de propionate de fluticasone
JP2003514841A (ja) * 1999-11-23 2003-04-22 グラクソ グループ リミテッド サルメテロールの医薬製剤
WO2001047493A1 (en) * 1999-12-24 2001-07-05 Glaxo Group Limited Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
IT1317846B1 (it) * 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
AU5070100A (en) 2000-05-22 2001-12-03 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers
WO2002072067A2 (en) * 2001-03-12 2002-09-19 Glaxo Group Limited Pharmaceutical aerosol formulation
EP1273292B1 (en) 2001-07-02 2004-05-26 CHIESI FARMACEUTICI S.p.A. Optimised formulation of tobramycin for aerosolization
EP1340503A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Solution aerosol formulation containing esters of 3, 17-dihydroxy oestratriene derivates for pulmonary delivery
EP1340492A1 (en) * 2002-03-01 2003-09-03 CHIESI FARMACEUTICI S.p.A. Aerosol formulations for pulmonary administration of medicaments having systemic effects
SI3494995T1 (sl) 2002-03-01 2020-08-31 Chiesi Farmaceutici S.P.A. Superfina formulacija formoterola
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
DE60216242T2 (de) * 2002-06-06 2007-05-24 Chiesi Farmaceutici S.P.A. Lösung von Wirkstoffen in HFA-Treibgasen mittels Emulsionen
WO2004071488A1 (en) * 2003-02-04 2004-08-26 Chrysalis Technologies Incorporated Perfluorocarbon and hydrofluorocarbon formulations and methods of making and using same
EA009087B1 (ru) 2003-03-20 2007-10-26 Бёрингер Ингельхайм Фармасьютиклз, Инк. Состав для ингалятора, выдающего мерную дозу препарата, с использованием гидрофторалканов в качестве пропеллентов
EP1915985A1 (en) 2003-03-20 2008-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants
SE0303179D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
PL1809243T5 (pl) 2004-07-02 2022-12-27 Boehringer Ingelheim International Gmbh Preparaty aerozolowe w postaci zawiesin z tg 227 ea jako propelent aerozolowy
DE102006017320A1 (de) 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
GB0621707D0 (en) * 2006-10-31 2006-12-13 Univ London Pharmacy Formulations for delivery via pressurised metered dose inhalers
GB0712454D0 (en) 2007-06-27 2007-08-08 Generics Uk Ltd Pharmaceutical compositions
BRPI0819259A2 (pt) * 2007-11-07 2019-10-01 Astrazeneca Ab formulações de pó seco compreendendo derivados do ácido ascórbico.
RU2561833C2 (ru) * 2010-09-06 2015-09-10 Кьези Фармасьютичи С.П.А. Дозирующий ингалятор и способ его применения
JP5409594B2 (ja) * 2010-12-22 2014-02-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
EP2819669B1 (de) 2012-02-28 2021-04-21 Boehringer Ingelheim International GmbH Neue treibgashaltige tiotropium-formulierung
RU2504402C1 (ru) * 2012-11-20 2014-01-20 Шолекс Девелопмент Гмбх Ингаляционный состав в форме аэрозоля для лечения бронхиальной астмы и хронической обструктивной болезни легких
GB201402513D0 (en) 2014-02-13 2014-04-02 Cardiff Scintigraphics Ltd Pressurised metered dose inhalers and method of manufacture
US20170189329A1 (en) 2014-07-29 2017-07-06 3M Innovative Properties Company Method of preparing a pharmaceutical composition
EP3436115B1 (en) 2016-03-31 2021-07-28 Chiesi Farmaceutici S.p.A. Aerosol inhalation device
JP6781832B2 (ja) * 2016-09-19 2020-11-04 メキシケム フロー エセ・ア・デ・セ・ヴェ 医薬組成物
WO2025039045A1 (en) * 2023-08-23 2025-02-27 Inhaler Supplies Pty Ltd Inhalable formulation for volatile actives

Family Cites Families (26)

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ES2038696T3 (es) † 1986-03-10 1996-07-16 Burghart Kurt Procedimiento para producir un preparado farmaceutico.
US4863720A (en) † 1986-03-10 1989-09-05 Walter Burghart Pharmaceutical preparation and methods for its production
US4899874A (en) † 1988-04-26 1990-02-13 Rehrig-Pacific Company, Inc. Stackable low depth bottle case
US5225183A (en) † 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
DE3905726A1 (de) * 1989-02-24 1990-08-30 Hoechst Ag Druckgaspackung und treibmittel fuer aerosole
JP2769925B2 (ja) † 1990-10-18 1998-06-25 ミネソタ マイニング アンド マニュファクチャリング カンパニー ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤
GB9024365D0 (en) * 1990-11-09 1991-01-02 Glaxo Group Ltd Medicaments
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
ES2180592T3 (es) † 1991-06-10 2003-02-16 Schering Corp Formulaciones en aerosol libres de clorofluorocarbonos.
US5474759A (en) * 1991-06-10 1995-12-12 Schering Corporation Non-chlorofluorocarbon aerosol formulations
DE4123663A1 (de) * 1991-07-17 1993-01-21 Schwabe Willmar Gmbh & Co Aerosol-zubereitung und verwendung eines treibmittels dafuer
DE4123668A1 (de) * 1991-07-17 1993-01-21 Rovema Gmbh Verfahren und vorrichtung zur zufuehrung von folienmaterial zu einer intermittierend arbeitenden schlauchbeutelmaschine
DE69205177T2 (de) * 1991-12-12 1996-03-21 Glaxo Group Ltd., Greenford, Middlesex Pharmazeutische Aerosolformulierung.
AU675633B2 (en) * 1991-12-18 1997-02-13 Minnesota Mining And Manufacturing Company Suspension aerosol formulations
WO1994013262A1 (en) * 1992-12-09 1994-06-23 Boehringer Ingelheim Pharmaceuticals, Inc. Stabilized medicinal aerosol solution formulations
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5508023A (en) * 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
US5534242A (en) † 1994-05-02 1996-07-09 Henry; Richard A. Lidocaine-vasoconstrictor aerosol preparation
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JP2001511160A (ja) † 1997-02-05 2001-08-07 ヤゴ リサーチ アクチェンゲゼルシャフト 医学用エアゾール配合物

Also Published As

Publication number Publication date
IS4974A (is) 1999-02-11
IL128484A0 (en) 2000-01-31
SK284430B6 (sk) 2005-04-01
PT920302E (pt) 2002-11-29
JP2000516965A (ja) 2000-12-19
EE03664B1 (et) 2002-04-15
AR012977A1 (es) 2000-11-22
BR9805993B1 (pt) 2009-05-05
BG63906B1 (bg) 2003-06-30
TR199900288T1 (xx) 1999-09-21
HRP980317B1 (en) 2002-06-30
SK284430B8 (sk) 2005-05-05
EP0920302B2 (en) 2006-06-21
SK17699A3 (en) 1999-07-12
RS51274B (sr) 2010-12-31
MEP44008A (hr) 2011-02-10
DK0920302T4 (da) 2006-10-09
EP0920302B1 (en) 2002-08-28
ID21491A (id) 1999-06-17
ATE222751T1 (de) 2002-09-15
ZA985136B (en) 1999-01-07
BR9805993A (pt) 1999-08-31
SI0920302T2 (sl) 2006-10-31
DZ2516A1 (fr) 2004-11-08
EP1219293A3 (en) 2003-05-28
IL128484A (en) 2004-09-27
CZ295521B6 (cs) 2005-08-17
EP1219293A2 (en) 2002-07-03
WO1998056349A1 (en) 1998-12-17
NO990594D0 (no) 1999-02-09
CA2263445A1 (en) 1998-12-17
BG103221A (bg) 1999-09-30
CZ46299A3 (cs) 1999-07-14
IN189317B (enExample) 2003-02-08
DE69807420D1 (de) 2002-10-02
CO4940408A1 (es) 2000-07-24
MA26507A1 (fr) 2004-12-20
DE69807420T3 (de) 2006-11-16
HUP0001339A3 (en) 2000-10-30
EE9900055A (et) 1999-08-16
TNSN98087A1 (fr) 2005-03-15
NZ334149A (en) 2000-07-28
EA199900201A1 (ru) 1999-06-24
KR20000068171A (ko) 2000-11-25
CN1229355A (zh) 1999-09-22
YU6999A (sh) 2000-03-21
PL331531A1 (en) 1999-07-19
AU729966B2 (en) 2001-02-15
HRP980317A2 (en) 1999-04-30
JP4380802B2 (ja) 2009-12-09
AU8626298A (en) 1998-12-30
SA98190821B1 (ar) 2006-11-19
GEP20012462B (en) 2001-06-25
KR100546239B1 (ko) 2006-01-26
EA001259B1 (ru) 2000-12-25
DK0920302T3 (da) 2002-12-23
IT1293803B1 (it) 1999-03-10
SI0920302T1 (sl) 2002-12-31
ME00333B (me) 2011-02-10
ITMI971798A1 (it) 1999-01-28
DE69807420T2 (de) 2003-05-08
HK1022271A1 (en) 2000-08-04
CA2263445C (en) 2008-09-09
ES2182351T5 (es) 2007-03-16
NO990594L (no) 1999-04-13
TW555570B (en) 2003-10-01
EP0920302A1 (en) 1999-06-09
MY119074A (en) 2005-03-31
NO327775B1 (no) 2009-09-21
GB9712434D0 (en) 1997-08-13
HUP0001339A2 (hu) 2000-09-28
UA70289C2 (uk) 2004-10-15
ES2182351T3 (es) 2003-03-01
PL193721B1 (pl) 2007-03-30
GB2326334A (en) 1998-12-23
HU228487B1 (en) 2013-03-28
IS2435B (is) 2008-10-15

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