CN113423428A - 刺激感得到了抑制的眼科组合物 - Google Patents

刺激感得到了抑制的眼科组合物 Download PDF

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Publication number
CN113423428A
CN113423428A CN202080013192.3A CN202080013192A CN113423428A CN 113423428 A CN113423428 A CN 113423428A CN 202080013192 A CN202080013192 A CN 202080013192A CN 113423428 A CN113423428 A CN 113423428A
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China
Prior art keywords
component
ophthalmic composition
irritation
group
trpa1
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Pending
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CN202080013192.3A
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English (en)
Chinese (zh)
Inventor
羽贺雅俊
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Rohto Pharmaceutical Co Ltd
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Rohto Pharmaceutical Co Ltd
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Publication of CN113423428A publication Critical patent/CN113423428A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biophysics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080013192.3A 2019-03-08 2020-03-06 刺激感得到了抑制的眼科组合物 Pending CN113423428A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2019-043089 2019-03-08
JP2019043089 2019-03-08
JP2019071396 2019-04-03
JP2019-071396 2019-04-03
PCT/JP2020/009847 WO2020184479A1 (ja) 2019-03-08 2020-03-06 刺激感が抑制された眼科組成物

Publications (1)

Publication Number Publication Date
CN113423428A true CN113423428A (zh) 2021-09-21

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ID=72427534

Family Applications (1)

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CN202080013192.3A Pending CN113423428A (zh) 2019-03-08 2020-03-06 刺激感得到了抑制的眼科组合物

Country Status (4)

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JP (2) JPWO2020184479A1 (https=)
CN (1) CN113423428A (https=)
TW (2) TW202100144A (https=)
WO (1) WO2020184479A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12601929B2 (en) * 2022-04-28 2026-04-14 Coopervision International Limited Contact lens

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09132526A (ja) * 1995-11-09 1997-05-20 Lion Corp 点眼剤
JP2003183157A (ja) * 2001-12-19 2003-07-03 Lion Corp 眼科用組成物
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
JP2009029779A (ja) * 2007-06-29 2009-02-12 Rohto Pharmaceut Co Ltd レボカバスチン及び／又はその塩を含有する水性医薬組成物
JP2011074092A (ja) * 2003-04-04 2011-04-14 Rohto Pharmaceutical Co Ltd 眼科用組成物
CN104039315A (zh) * 2012-01-05 2014-09-10 花王株式会社 用于降低感觉刺激的制剂
CN104918599A (zh) * 2012-05-25 2015-09-16 宝洁公司 用于减少trpa1和trpv1感觉的组合物
WO2018009717A1 (en) * 2016-07-06 2018-01-11 Algomedix, Inc. Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505909A (en) * 1980-09-17 1985-03-19 Bernstein Joel E Method and composition for treating and preventing irritation of the eyes
JP3597239B2 (ja) * 1994-03-31 2004-12-02 ライオン株式会社 安定な点眼剤
JPH09169642A (ja) * 1995-12-18 1997-06-30 Lion Corp テトラヒドロゾリン含有液剤
JPH09309835A (ja) * 1996-05-21 1997-12-02 Lion Corp グリチルリチン酸アルキルエステル含有薬液
JP2000327573A (ja) * 1999-05-18 2000-11-28 Taisho Pharmaceut Co Ltd 粘膜適用組成物
JP2001302518A (ja) * 2000-02-15 2001-10-31 Rohto Pharmaceut Co Ltd 官能改善方法および官能改善剤
JP2003073303A (ja) * 2001-09-05 2003-03-12 Senju Pharmaceut Co Ltd 眼局所用液剤の清涼化作用の持続方法
JP4174648B2 (ja) * 2001-11-12 2008-11-05 ロート製薬株式会社 水性組成物
US6982079B2 (en) * 2002-04-26 2006-01-03 Allergan, Inc. Compositions for treating hyperemia
JP2004143156A (ja) * 2002-10-01 2004-05-20 Taisho Pharmaceut Co Ltd 点眼剤
JP2004175770A (ja) * 2002-11-29 2004-06-24 Rohto Pharmaceut Co Ltd ケトチフェン及びイミダゾリン化合物含有組成物
JP5052028B2 (ja) * 2005-04-08 2012-10-17 ロート製薬株式会社 アシタザノラスト含有組成物
JP4979258B2 (ja) * 2005-04-08 2012-07-18 ロート製薬株式会社 アシタザノラスト含有水性組成物
WO2007108541A1 (ja) * 2006-03-23 2007-09-27 Senju Pharmaceutical Co., Ltd. キサンタンガムおよびブドウ糖を含有する眼科用組成物
JP2008024700A (ja) * 2006-06-23 2008-02-07 Rohto Pharmaceut Co Ltd ベルベリン含有水性組成物
JP5258329B2 (ja) * 2007-06-01 2013-08-07 ロート製薬株式会社 プラノプロフェン含有水性医薬組成物
WO2011040572A1 (ja) * 2009-09-30 2011-04-07 ロート製薬株式会社 眼科組成物
JP5595206B2 (ja) * 2009-09-30 2014-09-24 ロート製薬株式会社 眼科用液体組成物
JP2012144509A (ja) * 2011-01-12 2012-08-02 Saga Seiyaku Kk 多成分配合の点眼剤
JP5736211B2 (ja) * 2011-03-29 2015-06-17 ロート製薬株式会社 眼科用組成物
EP3219303B1 (de) * 2012-01-30 2019-11-06 Symrise AG Zubereitungen
JP2013237638A (ja) * 2012-05-15 2013-11-28 Lion Corp 眼科組成物
JP6177594B2 (ja) * 2012-06-14 2017-08-09 ロート製薬株式会社 水性眼科組成物
JP6353365B2 (ja) * 2012-09-27 2018-07-04 千寿製薬株式会社 水性液剤
JP6177019B2 (ja) * 2013-01-31 2017-08-09 ロート製薬株式会社 点眼剤
JP5730355B2 (ja) * 2013-07-24 2015-06-10 学校法人近畿大学 Ｃｙｐ２ａ１３阻害剤
EP3093002B1 (de) * 2015-05-15 2018-04-25 Symrise AG Flüssige kühlstoffzubereitungen
JP2017119669A (ja) * 2015-10-15 2017-07-06 ロート製薬株式会社 異物感改善用眼科組成物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09132526A (ja) * 1995-11-09 1997-05-20 Lion Corp 点眼剤
JP2003183157A (ja) * 2001-12-19 2003-07-03 Lion Corp 眼科用組成物
JP2011074092A (ja) * 2003-04-04 2011-04-14 Rohto Pharmaceutical Co Ltd 眼科用組成物
JP2006176501A (ja) * 2004-11-26 2006-07-06 Taisho Pharmaceut Co Ltd 眼科用剤
JP2009029779A (ja) * 2007-06-29 2009-02-12 Rohto Pharmaceut Co Ltd レボカバスチン及び／又はその塩を含有する水性医薬組成物
CN104039315A (zh) * 2012-01-05 2014-09-10 花王株式会社 用于降低感觉刺激的制剂
CN104918599A (zh) * 2012-05-25 2015-09-16 宝洁公司 用于减少trpa1和trpv1感觉的组合物
WO2018009717A1 (en) * 2016-07-06 2018-01-11 Algomedix, Inc. Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation

Also Published As

Publication number Publication date
TW202100144A (zh) 2021-01-01
TW202545507A (zh) 2025-12-01
WO2020184479A1 (ja) 2020-09-17
JPWO2020184479A1 (https=) 2020-09-17
JP2024180505A (ja) 2024-12-26

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