CN113227376B - 核酸、药物组合物与缀合物及制备方法和用途 - Google Patents

核酸、药物组合物与缀合物及制备方法和用途 Download PDF

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CN113227376B
CN113227376B CN202080007282.1A CN202080007282A CN113227376B CN 113227376 B CN113227376 B CN 113227376B CN 202080007282 A CN202080007282 A CN 202080007282A CN 113227376 B CN113227376 B CN 113227376B
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nucleotide sequence
sirna
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antisense strand
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CN113227376A (zh
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张鸿雁
高山
康代武
刘涛
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Suzhou Ruibo Biotechnology Co ltd
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JP7610848B2 (ja) * 2019-05-22 2025-01-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、薬物組成物及び複合体ならびに調製方法と使用
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CN113795582B (zh) 2019-05-24 2024-05-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
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WO2025031282A1 (zh) * 2023-08-04 2025-02-13 深圳信立泰药业股份有限公司 一种靶向FXI的RNAi剂、其制备方法及用途
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TW202546229A (zh) * 2024-01-26 2025-12-01 大陸商石藥集團中奇製藥技術（石家莊）有限公司 抑制ｆ１１基因表達的核酸分子或其鹽、第二核酸分子、病毒顆粒、細胞或藥物組合物及其用途
TW202603167A (zh) * 2024-03-22 2026-01-16 美商靖因藥業（上海）有限公司 用於抑制ｆｘｉ表現之聚核酸分子、醫藥組合物及其用途
CN121087035A (zh) * 2024-06-06 2025-12-09 北京福元医药股份有限公司 抑制FXI基因表达的siRNA、其缀合物和药物组合物及用途
WO2026002238A1 (zh) * 2024-06-28 2026-01-02 成都新泽利医药科技有限公司 抑制凝血因子XI表达的siRNA及其用途
WO2026017140A2 (en) * 2024-07-18 2026-01-22 Sanegene Bio Usa Inc. Small interfering rna targeting fxi and uses thereof
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WO2026082165A1 (zh) * 2024-10-18 2026-04-23 正大天晴药业集团股份有限公司 修饰的双链核糖核酸
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