CN113227376A - 核酸、药物组合物与缀合物及制备方法和用途 - Google Patents

核酸、药物组合物与缀合物及制备方法和用途 Download PDF

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CN113227376A
CN113227376A CN202080007282.1A CN202080007282A CN113227376A CN 113227376 A CN113227376 A CN 113227376A CN 202080007282 A CN202080007282 A CN 202080007282A CN 113227376 A CN113227376 A CN 113227376A
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nucleotide sequence
nucleotide
seq
sirna
nucleotides
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CN113227376B (zh
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张鸿雁
高山
康代武
刘涛
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Suzhou Ruibo Biotechnology Co Ltd
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Abstract

提供了抑制血浆凝血因子XI基因表达的siRNA，含有siRNA的药物组合物和缀合物，试剂盒，以及siRNA及其药物组合物和缀合物在制备用于治疗和/或预防血栓性疾病和缺血性卒中的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (71)

  1. PCT国内申请，权利要求书已公开。
CN202080007282.1A 2019-05-22 2020-05-21 核酸、药物组合物与缀合物及制备方法和用途 Active CN113227376B (zh)

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WO2024125636A1 (zh) * 2022-12-16 2024-06-20 上海拓界生物医药科技有限公司 Toll样受体调节剂与dsRNA的联合治疗
WO2024140986A1 (zh) * 2022-12-30 2024-07-04 北京福元医药股份有限公司 用于抑制凝血因子xi基因表达的双链核糖核酸及其修饰物、缀合物和用途

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WO2022028457A1 (zh) * 2020-08-04 2022-02-10 上海拓界生物医药科技有限公司 抑制凝血因子XI表达的siRNA、组合物及其医药用途
EP4323523A2 (en) 2021-04-13 2024-02-21 Sirnaomics, Inc. Products and compositions
AU2022261027A1 (en) * 2021-04-22 2023-10-26 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting 17β-hydroxysteroid dehydrogenase type 13 and sirna conjugate
KR20240116537A (ko) * 2021-12-16 2024-07-29 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 dsRNA, 이의 제조 방법 및 응용
WO2023109945A1 (zh) * 2021-12-16 2023-06-22 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用

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WO2024140986A1 (zh) * 2022-12-30 2024-07-04 北京福元医药股份有限公司 用于抑制凝血因子xi基因表达的双链核糖核酸及其修饰物、缀合物和用途

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