CN110945130A - 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 - Google Patents

一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 Download PDF

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CN110945130A
CN110945130A CN201880048600.1A CN201880048600A CN110945130A CN 110945130 A CN110945130 A CN 110945130A CN 201880048600 A CN201880048600 A CN 201880048600A CN 110945130 A CN110945130 A CN 110945130A
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sirna
nucleotide
seq
nucleotide sequence
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CN110945130B (zh
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张鸿雁
高山
康代武
孔丽娜
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Abstract

提供了一种抑制血管生成素样蛋白3(ANGPTL3)基因表达的siRNA，以及含有该siRNA的药物组合物和缀合物。该siRNA中的每个核苷酸各自独立地为修饰或未修饰的核苷酸，该siRNA含有正义链和反义链，所述正义链含有核苷酸序列A，所述核苷酸序列A与SEQ ID NO:1所示的核苷酸序列长度相等，且不多于3个核苷酸差异，所述反义链含有核苷酸序列B，所述核苷酸序列B与SEQ ID NO:2所示的核苷酸序列长度相等，且不多于3个核苷酸差异。

Description

PCT国内申请，说明书已公开。

Claims (75)

  1. PCT国内申请，权利要求书已公开。
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WO2024027518A1 (zh) * 2022-08-04 2024-02-08 北京福元医药股份有限公司 用于抑制angptl3基因表达的双链核糖核酸及其修饰物、缀合物和用途

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