CN1127299A - 提纯重组体人血清清蛋白的方法 - Google Patents
提纯重组体人血清清蛋白的方法 Download PDFInfo
- Publication number
- CN1127299A CN1127299A CN95117159A CN95117159A CN1127299A CN 1127299 A CN1127299 A CN 1127299A CN 95117159 A CN95117159 A CN 95117159A CN 95117159 A CN95117159 A CN 95117159A CN 1127299 A CN1127299 A CN 1127299A
- Authority
- CN
- China
- Prior art keywords
- rhsa
- human serum
- heating
- serum albumin
- recombinant human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
Abstract
Description
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20770494 | 1994-08-31 | ||
JP207704/94 | 1994-08-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN01123056A Division CN1364643A (zh) | 1994-08-31 | 2001-07-19 | 提纯重组体人血清清蛋白的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1127299A true CN1127299A (zh) | 1996-07-24 |
CN1080301C CN1080301C (zh) | 2002-03-06 |
Family
ID=16544190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95117159A Expired - Lifetime CN1080301C (zh) | 1994-08-31 | 1995-08-31 | 提纯重组体人血清清蛋白的方法 |
CN01123056A Pending CN1364643A (zh) | 1994-08-31 | 2001-07-19 | 提纯重组体人血清清蛋白的方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN01123056A Pending CN1364643A (zh) | 1994-08-31 | 2001-07-19 | 提纯重组体人血清清蛋白的方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US5962649A (zh) |
EP (1) | EP0699687B1 (zh) |
KR (1) | KR100392021B1 (zh) |
CN (2) | CN1080301C (zh) |
CA (1) | CA2157219C (zh) |
DE (1) | DE69532492T2 (zh) |
DK (1) | DK0699687T3 (zh) |
ES (1) | ES2211889T3 (zh) |
TW (1) | TW363065B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102190722A (zh) * | 2010-03-16 | 2011-09-21 | 上海安睿特生物医药科技有限公司 | 一种纯化重组人血白蛋白的方法 |
WO2022120547A1 (zh) | 2020-12-08 | 2022-06-16 | 通化安睿特生物制药股份有限公司 | 纯化重组蛋白的方法 |
Families Citing this family (66)
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US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
DE69532492T2 (de) * | 1994-08-31 | 2004-12-02 | Mitsubishi Pharma Corp. | Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin |
AU4837996A (en) * | 1996-02-29 | 1997-09-16 | Delta Biotechnology Limited | High purity albumin production process |
US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
EP0947581A4 (en) * | 1996-08-08 | 2004-07-28 | Mitsubishi Pharma Corp | CULTURAL MEDIUM AND ITS USE. |
IL137649A (en) * | 1998-02-18 | 2004-08-31 | Genentech Inc | Method of adsorption chromatography |
US7351249B2 (en) * | 1998-11-06 | 2008-04-01 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of suture sites |
US7279001B2 (en) * | 1998-11-06 | 2007-10-09 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6830756B2 (en) * | 1998-11-06 | 2004-12-14 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6899889B1 (en) * | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
US20040101964A1 (en) * | 2000-05-10 | 2004-05-27 | Shigemitsu Takashima | Method of preparing virus vector |
US6787636B1 (en) | 2000-07-14 | 2004-09-07 | New Century Pharmaceuticals, Inc. | Modified serum albumin with reduced affinity for nickel and copper |
EP1175931A1 (en) * | 2000-07-25 | 2002-01-30 | Computer Cell Culture Center S.A. | Integration of high cell density bioreactor operation with ultra fast on-line downstream processing |
JP4159878B2 (ja) | 2001-02-01 | 2008-10-01 | エフ.ホフマン−ラ ロシュ アーゲー | 組換えトリプシンの製造方法 |
JP2002265383A (ja) * | 2001-03-14 | 2002-09-18 | Mitsubishi Pharma Corp | インターフェロンα注射用液状製剤 |
DE60224284T2 (de) | 2001-06-28 | 2008-12-18 | Novo Nordisk A/S | Stabile formulierung von modifiziertem glp-1 |
ITBO20010426A1 (it) | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
KR20030007186A (ko) * | 2001-07-17 | 2003-01-23 | 미쯔이카가쿠 가부시기가이샤 | 광 양이온성 경화가능 수지 조성물 및 그 용도 |
ATE477810T1 (de) * | 2002-02-28 | 2010-09-15 | Nipro Corp | Stabilisierte albumin-zubereitungen |
SE526227C2 (sv) | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
AU2003281982A1 (en) * | 2002-11-26 | 2004-06-18 | Novo Nordisk A/S | Process for purifying a fermentation-derived product |
CA2514981A1 (en) * | 2003-03-12 | 2004-09-23 | Fresenius Kabi Deutschland Gmbh | Use of recombinant albumin in dialysis after liver failure |
WO2004105790A1 (en) | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
CN102940879B (zh) | 2003-06-03 | 2017-06-06 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
CN104826116A (zh) | 2003-11-20 | 2015-08-12 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
JP2005245269A (ja) * | 2004-03-03 | 2005-09-15 | Nipro Corp | 血清アルブミン多量体を含む遺伝子組換え型蛋白質 |
PL1745078T3 (pl) * | 2004-04-23 | 2009-12-31 | Conjuchem Biotechnologies Inc | Sposób oczyszczania koniugatów albumin |
EP1765866B1 (en) | 2004-06-07 | 2014-01-08 | Therapure Biopharma Inc. | Isolation of plasma or serum proteins |
CN100374560C (zh) * | 2004-08-27 | 2008-03-12 | 富岩 | 高效表达人血清白蛋白酵母菌株的构建及发酵纯化工艺 |
ES2442223T3 (es) | 2004-08-31 | 2014-02-10 | Novo Nordisk A/S | Uso de tris(hidroximetil) aminometano para la estabilización de péptidos, polipéptidos y proteínas |
CN106137952B (zh) | 2004-11-12 | 2020-11-17 | 诺和诺德公司 | 促胰岛素肽的稳定制剂 |
CN1854306B (zh) * | 2005-04-29 | 2011-07-27 | 华北制药集团新药研究开发有限责任公司 | 发酵生产重组人血清白蛋白hsa的方法 |
IL169230A (en) | 2005-06-16 | 2012-03-29 | Plasan Sasa Agricultural Cooperative Soc Ltd | Ballistic armor |
WO2007063129A2 (en) * | 2005-12-02 | 2007-06-07 | Novozymes A/S | Insolation of peptides , polypeptides and proteins |
JP4935242B2 (ja) * | 2006-08-24 | 2012-05-23 | ニプロ株式会社 | 脂肪酸を含有するs−ニトロソタンパク質とその製法 |
US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
US20100267933A1 (en) | 2006-12-21 | 2010-10-21 | Moya Wilson | Purification of proteins |
RU2483111C2 (ru) * | 2007-01-15 | 2013-05-27 | Апфрант Кроматографи А/С | Производство биотоплива и белка из сырья |
ES2749232T3 (es) | 2008-12-16 | 2020-03-19 | Emd Millipore Corp | Reactor de tanque agitado y procedimiento |
EP2398896A4 (en) | 2009-02-20 | 2013-02-20 | Ventria Bioscience | CELL CULTURE MEDIUM CONTAINING COMBINATIONS OF PROTEINS |
SG10201804385YA (en) | 2010-05-17 | 2018-06-28 | Emd Millipore Corp | Stimulus responsive polymers for the purification of biomolecules |
CN102532254B (zh) * | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
US20140235474A1 (en) | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
ES2929923T3 (es) | 2012-01-20 | 2022-12-02 | Sequenom Inc | Procesos de diagnóstico que condicionan las condiciones experimentales |
US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
PL2981921T3 (pl) | 2013-04-03 | 2023-05-08 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
EP3004383B1 (en) | 2013-05-24 | 2019-04-24 | Sequenom, Inc. | Methods for non-invasive assessment of genetic variations using area-under-curve (auc) analysis |
AU2014284180B2 (en) | 2013-06-21 | 2020-03-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2015051163A2 (en) | 2013-10-04 | 2015-04-09 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2925111C (en) | 2013-10-07 | 2024-01-16 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
US11783911B2 (en) | 2014-07-30 | 2023-10-10 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
SI3240798T1 (sl) | 2015-01-01 | 2020-07-31 | Shilpa Medicare Limited | Nov postopek za učinkovito čiščenje humanega serumskega albumina |
WO2018022890A1 (en) | 2016-07-27 | 2018-02-01 | Sequenom, Inc. | Genetic copy number alteration classifications |
JP7237003B2 (ja) | 2017-01-24 | 2023-03-10 | セクエノム, インコーポレイテッド | 遺伝子片の評価のための方法およびプロセス |
TWI762706B (zh) | 2017-08-24 | 2022-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
WO2021144476A1 (en) | 2020-02-18 | 2021-07-22 | Novo Nordisk A/S | Pharmaceutical formulations |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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FR570916A (zh) | 1923-09-20 | 1924-05-09 | ||
US4228154A (en) * | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
KR830002718A (ko) | 1980-04-22 | 1983-05-30 | 가와무라 요시부미 | 피라졸 유도체의 제조법 |
US4665192A (en) * | 1984-03-19 | 1987-05-12 | The Rockefeller University | 2-(2-furoyl)-4(5)-2(furanyl)-1H-imidazole |
FR2649991B2 (fr) * | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
JPH0671434B2 (ja) * | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
WO1993001207A1 (en) * | 1991-07-12 | 1993-01-21 | Gist-Brocades N.V. | Process for the purification of serum albumin |
JPH07102147B2 (ja) * | 1992-03-16 | 1995-11-08 | 株式会社ミドリ十字 | ヒト血清アルブミンの着色抑制方法 |
US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
DE69532492T2 (de) * | 1994-08-31 | 2004-12-02 | Mitsubishi Pharma Corp. | Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin |
-
1995
- 1995-08-30 DE DE69532492T patent/DE69532492T2/de not_active Expired - Lifetime
- 1995-08-30 DK DK95113620T patent/DK0699687T3/da active
- 1995-08-30 EP EP95113620A patent/EP0699687B1/en not_active Expired - Lifetime
- 1995-08-30 ES ES95113620T patent/ES2211889T3/es not_active Expired - Lifetime
- 1995-08-30 CA CA2157219A patent/CA2157219C/en not_active Expired - Lifetime
- 1995-08-31 CN CN95117159A patent/CN1080301C/zh not_active Expired - Lifetime
- 1995-08-31 KR KR1019950027882A patent/KR100392021B1/ko active IP Right Grant
- 1995-08-31 US US08/522,089 patent/US5962649A/en not_active Expired - Lifetime
- 1995-09-11 TW TW084109447A patent/TW363065B/zh not_active IP Right Cessation
-
1999
- 1999-05-24 US US09/317,214 patent/US6617133B1/en not_active Expired - Lifetime
-
2001
- 2001-07-19 CN CN01123056A patent/CN1364643A/zh active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102190722A (zh) * | 2010-03-16 | 2011-09-21 | 上海安睿特生物医药科技有限公司 | 一种纯化重组人血白蛋白的方法 |
CN102190722B (zh) * | 2010-03-16 | 2014-03-26 | 上海欣瑞特生物医药技术有限公司 | 一种纯化重组人血白蛋白的方法 |
WO2022120547A1 (zh) | 2020-12-08 | 2022-06-16 | 通化安睿特生物制药股份有限公司 | 纯化重组蛋白的方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2211889T3 (es) | 2004-07-16 |
US6617133B1 (en) | 2003-09-09 |
EP0699687A3 (en) | 1996-12-18 |
US5962649A (en) | 1999-10-05 |
KR960007612A (ko) | 1996-03-22 |
EP0699687A2 (en) | 1996-03-06 |
DK0699687T3 (da) | 2004-04-26 |
DE69532492D1 (de) | 2004-03-04 |
KR100392021B1 (ko) | 2003-11-01 |
CN1080301C (zh) | 2002-03-06 |
CN1364643A (zh) | 2002-08-21 |
TW363065B (en) | 1999-07-01 |
CA2157219C (en) | 2010-10-05 |
DE69532492T2 (de) | 2004-12-02 |
CA2157219A1 (en) | 1996-03-01 |
EP0699687B1 (en) | 2004-01-28 |
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C53 | Correction of patent for invention or patent application | ||
CB02 | Change of applicant information |
Applicant after: Yoshitomi Pharmaceutical Industries, Ltd. Applicant before: GREEN CROSS Corp. |
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Free format text: CORRECT: APPLICANT; FROM: THE GREEN CROSS CORPORATION TO: YOSHITOMI PHARMACEUTICAL INDUSTRIES CO., LTD. |
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Applicant after: Yoshitomi Pharmaceutical Industries Ltd. Applicant before: Gifford Pharmaceuticals Inc. |
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Free format text: CORRECT: APPLICANT; FROM: JIFU PHARMACEUTICAL CO., LTD. TO: WEIFU CO., LTD. |
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C14 | Grant of patent or utility model | ||
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Owner name: MITSUBISHI PHARMACEUTICAL CORP. Free format text: FORMER OWNER: WEIFU CO., LTD. Effective date: 20021213 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20021213 Patentee after: Mitsubishi Pharmaceutical Co., Ltd. Patentee before: Yoshitomi Pharmaceutical Industries Ltd. |
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CX01 | Expiry of patent term |
Expiration termination date: 20150831 Granted publication date: 20020306 |
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