CN1122719C - 经修饰的生物材料 - Google Patents

经修饰的生物材料 Download PDF

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Publication number
CN1122719C
CN1122719C CN90108275A CN90108275A CN1122719C CN 1122719 C CN1122719 C CN 1122719C CN 90108275 A CN90108275 A CN 90108275A CN 90108275 A CN90108275 A CN 90108275A CN 1122719 C CN1122719 C CN 1122719C
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CN
China
Prior art keywords
species
complement
hcrf
cells
recipient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN90108275A
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English (en)
Chinese (zh)
Other versions
CN1051199A (zh
Inventor
戴维·詹姆斯·吉拉哈姆·怀特
阿兰·弗莱德里克·威廉姆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imutran Ltd
Original Assignee
Imutran Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26296038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1122719(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB898922987A external-priority patent/GB8922987D0/en
Priority claimed from GB909017198A external-priority patent/GB9017198D0/en
Application filed by Imutran Ltd filed Critical Imutran Ltd
Publication of CN1051199A publication Critical patent/CN1051199A/zh
Application granted granted Critical
Publication of CN1122719C publication Critical patent/CN1122719C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
CN90108275A 1989-10-12 1990-10-12 经修饰的生物材料 Expired - Fee Related CN1122719C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8922987.6 1989-10-12
GB898922987A GB8922987D0 (en) 1989-10-12 1989-10-12 Modified biological material
GB909017198A GB9017198D0 (en) 1990-08-06 1990-08-06 Modified biological material
GB9017198.4 1990-08-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA021302499A Division CN1491624A (zh) 1989-10-12 1990-10-12 经修饰的生物材料

Publications (2)

Publication Number Publication Date
CN1051199A CN1051199A (zh) 1991-05-08
CN1122719C true CN1122719C (zh) 2003-10-01

Family

ID=26296038

Family Applications (2)

Application Number Title Priority Date Filing Date
CN90108275A Expired - Fee Related CN1122719C (zh) 1989-10-12 1990-10-12 经修饰的生物材料
CNA021302499A Pending CN1491624A (zh) 1989-10-12 1990-10-12 经修饰的生物材料

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA021302499A Pending CN1491624A (zh) 1989-10-12 1990-10-12 经修饰的生物材料

Country Status (27)

Country Link
US (1) US6495735B1 (enExample)
EP (2) EP0709459A3 (enExample)
JP (1) JP3302358B2 (enExample)
KR (2) KR920702410A (enExample)
CN (2) CN1122719C (enExample)
AT (1) ATE139562T1 (enExample)
AU (1) AU654116B2 (enExample)
BG (1) BG61080B1 (enExample)
CA (1) CA2067235A1 (enExample)
CY (1) CY1996A (enExample)
DE (2) DE69027535T2 (enExample)
DK (1) DK0495852T3 (enExample)
ES (1) ES2060561T3 (enExample)
FI (1) FI921618A0 (enExample)
GR (2) GR940300004T1 (enExample)
HK (1) HK48497A (enExample)
HU (1) HUT64584A (enExample)
IE (1) IE75345B1 (enExample)
IL (2) IL95970A0 (enExample)
IN (1) IN171948B (enExample)
MY (1) MY107433A (enExample)
NO (2) NO303502B1 (enExample)
NZ (2) NZ235657A (enExample)
PT (2) PT95580B (enExample)
RO (1) RO109863B1 (enExample)
SG (1) SG72614A1 (enExample)
WO (1) WO1991005855A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705732A (en) * 1989-06-12 1998-01-06 Oklahoma Medical Research Foundation Universal donor cells
AU651068B2 (en) * 1989-07-21 1994-07-14 Washington University Recombinantly produced human membrane cofactor protein (MCP)
US5846715A (en) * 1990-05-11 1998-12-08 The Austin Research Institute CD46 variants
DE69133111D1 (de) * 1990-05-11 2002-10-24 Austin Res Inst Heidelberg CD46 Isoformen
WO1993002188A1 (en) * 1991-07-15 1993-02-04 Oklahoma Medical Research Foundation Universal donor cells
US6916654B1 (en) * 1992-06-29 2005-07-12 Oklahoma Medical Research Foundation Universal donor cells
FI951325L (fi) * 1992-09-22 1995-05-09 Dnx Biotherapeutics Inc Proteiinien kuljetus membraanien välisellä siirrolla ksenogeenisten elinsiirrännäisten esisovittamista varten ja muihin tarkoituksiin
US5627264A (en) * 1994-03-03 1997-05-06 Alexion Pharmaceuticals, Inc. Chimeric complement inhibitor proteins
CA2196311A1 (en) * 1994-08-19 1996-02-29 David H. Sachs Genetically engineered swine cells
WO1997006241A1 (en) 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU1933897A (en) * 1996-03-22 1997-10-17 Imutran Limited Surfaces which prevent or reduce complement activation
CN1192109C (zh) 1997-03-26 2005-03-09 帝国学院创新有限公司 锚定于细胞膜的抗凝血融合蛋白
US6825395B1 (en) 1997-07-14 2004-11-30 Nippon Meat Packers, Inc. Transgenic non-human mammals expressing the human complement inhibitor (DAF/CD55)
US7419683B2 (en) * 1997-10-31 2008-09-02 United States Of America As Represented By The Secretary Of The Army Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
SE523817C2 (sv) 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
GB9905503D0 (en) 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
EP1651050B1 (en) 2003-07-21 2012-08-22 Lifecell Corporation Acellular tissue matrices made from galactose alpha-1,3-galactose -deficient tissue
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア， インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
SG188328A1 (en) 2010-09-03 2013-04-30 Stem Centrx Inc Novel modulators and methods of use
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
CA2925332C (en) 2013-11-04 2022-07-12 Lifecell Corporation Methods of removing alpha-galactose
CN114686427B (zh) * 2022-05-23 2022-07-29 中国人民解放军总医院第一医学中心 一种脾脏调节型b淋巴细胞及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001041A1 (en) * 1987-08-06 1989-02-09 Genentech, Inc. Nucleic acid and methods for the synthesis of novel fusion polypeptides with a phospholipid anchor domain

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081570A4 (en) * 1981-06-12 1985-09-02 Univ Ohio GENETIC TRANSFORMATION OF ZYGOTS.
US4431636A (en) 1982-05-24 1984-02-14 American Cyanamid Company Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
JPS62104594A (ja) * 1985-10-31 1987-05-15 Terumo Corp クエン酸塩利用能検査用培地組成物
JPH0742235B2 (ja) * 1985-11-08 1995-05-10 三共株式会社 自己免疫性疾病の予防・治療剤
IL82390A0 (en) * 1986-05-02 1987-10-30 Genentech Inc Nucleic acid and methods for the synthesis of novel daf compositions
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
IL89790A (en) * 1988-04-01 2002-05-23 Johns Hopking University Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification
DE3830271A1 (de) 1988-09-06 1990-03-15 Goetze Otto Mittel mit immunsuppressiver wirkung
US5573940A (en) * 1989-06-12 1996-11-12 Oklahoma Medical Research Foundation Cells expressing high levels of CD59

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001041A1 (en) * 1987-08-06 1989-02-09 Genentech, Inc. Nucleic acid and methods for the synthesis of novel fusion polypeptides with a phospholipid anchor domain

Also Published As

Publication number Publication date
NO921438L (no) 1992-04-10
DK0495852T3 (da) 1996-07-15
PT95580B (pt) 1999-05-31
ES2060561T1 (es) 1994-12-01
KR100317106B1 (ko) 2001-12-22
EP0495852A1 (en) 1992-07-29
IN171948B (enExample) 1993-02-13
ATE139562T1 (de) 1996-07-15
CN1051199A (zh) 1991-05-08
GR940300004T1 (en) 1994-02-28
EP0709459A3 (en) 1999-01-07
IE75345B1 (en) 1997-08-27
NZ248153A (en) 1997-07-27
AU6539290A (en) 1991-05-16
MY107433A (en) 1995-12-30
HK48497A (en) 1997-04-25
SG72614A1 (en) 2000-05-23
DE495852T1 (de) 1994-03-31
HUT64584A (en) 1994-01-28
RO109863B1 (ro) 1995-06-30
EP0495852B1 (en) 1996-06-19
US6495735B1 (en) 2002-12-17
CN1491624A (zh) 2004-04-28
NO921438D0 (no) 1992-04-10
DE69027535D1 (de) 1996-07-25
NO982131D0 (no) 1998-05-11
KR920702410A (ko) 1992-09-04
JP3302358B2 (ja) 2002-07-15
IE903649A1 (en) 1991-04-24
BG96329A (bg) 1993-12-24
EP0709459A2 (en) 1996-05-01
IL95970A0 (en) 1992-05-25
HU9201240D0 (en) 1992-06-29
GR3020741T3 (en) 1996-11-30
JPH05503074A (ja) 1993-05-27
ES2060561T3 (es) 1996-08-01
CA2067235A1 (en) 1991-04-13
CY1996A (en) 1997-09-05
BG61080B1 (bg) 1996-10-31
PT101896A (pt) 1998-02-27
NO982131L (no) 1992-04-10
NO303502B1 (no) 1998-07-20
AU654116B2 (en) 1994-10-27
WO1991005855A1 (en) 1991-05-02
IL120795A0 (en) 1997-09-30
FI921618L (fi) 1992-04-10
DE69027535T2 (de) 1996-11-28
FI921618A7 (fi) 1992-04-10
NZ235657A (en) 1994-05-26
PT101896B (pt) 2003-01-31
FI921618A0 (fi) 1992-04-10
PT95580A (pt) 1991-09-13

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