ES2060561T1 - Material biologico modificado. - Google Patents
Material biologico modificado.Info
- Publication number
- ES2060561T1 ES2060561T1 ES90915320T ES90915320T ES2060561T1 ES 2060561 T1 ES2060561 T1 ES 2060561T1 ES 90915320 T ES90915320 T ES 90915320T ES 90915320 T ES90915320 T ES 90915320T ES 2060561 T1 ES2060561 T1 ES 2060561T1
- Authority
- ES
- Spain
- Prior art keywords
- species
- rejection
- biological material
- modified biological
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012620 biological material Substances 0.000 title 1
- 230000000295 complement effect Effects 0.000 abstract 2
- 230000024203 complement activation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
CONVENCIONALMENTE, EL TEJIDO ANIMAL DE UNA ESPECIE SE PUEDE TRANSPLANTAR SOLAMENTE A OTRA ESPECIE CUANDO LAS ESPECIES SON CONCORDANTES; DE OTRA FORMA OCURRE UN RECHAZO HIPERINMUNE. EN ESTA INVENCION SE MODIFICA EL TEJIDO DEL DONANTE, POR EJEMPLO SIENDO TRANSGENICO, PARA EXPRESAR O ESTAR EN ASOCIACION CON UNA O MAS SUSTANCIAS, LLAMADAS FACTORES DE RESTRICCION COMPLEMENTARIA MONOLOGOS (HCRFS), QUE SON ACTIVOS EN LAS ESPECIES DE RECIPIENTE PARA PREVENIR LA COMPLETA ACTIVACION DEL COMPLEMENTO Y POR LO TANTO EL RECHAZO. LA INVENCION ESTA BASADA EN PARTE EN EL DESCUBRIMIENTO DE QUE EL CAMINO ALTERNATIVO DE ACTIVACION DE COMPLEMENTO, ES RESPONSABLE DEL RECHAZO DE INJERTOS EXTRAÑOS DISCORDANTE, MAS BIEN QUE EL CAMINO CLASICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898922987A GB8922987D0 (en) | 1989-10-12 | 1989-10-12 | Modified biological material |
GB909017198A GB9017198D0 (en) | 1990-08-06 | 1990-08-06 | Modified biological material |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2060561T1 true ES2060561T1 (es) | 1994-12-01 |
ES2060561T3 ES2060561T3 (es) | 1996-08-01 |
Family
ID=26296038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90915320T Expired - Lifetime ES2060561T3 (es) | 1989-10-12 | 1990-10-12 | Material biologico modificado. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6495735B1 (es) |
EP (2) | EP0709459A3 (es) |
JP (1) | JP3302358B2 (es) |
KR (2) | KR920702410A (es) |
CN (2) | CN1122719C (es) |
AT (1) | ATE139562T1 (es) |
AU (1) | AU654116B2 (es) |
BG (1) | BG61080B1 (es) |
CA (1) | CA2067235A1 (es) |
CY (1) | CY1996A (es) |
DE (2) | DE69027535T2 (es) |
DK (1) | DK0495852T3 (es) |
ES (1) | ES2060561T3 (es) |
FI (1) | FI921618A (es) |
GR (2) | GR940300004T1 (es) |
HK (1) | HK48497A (es) |
HU (1) | HUT64584A (es) |
IE (1) | IE75345B1 (es) |
IL (2) | IL95970A0 (es) |
IN (1) | IN171948B (es) |
MY (1) | MY107433A (es) |
NO (2) | NO303502B1 (es) |
NZ (2) | NZ248153A (es) |
PT (2) | PT95580B (es) |
RO (1) | RO109863B1 (es) |
SG (1) | SG72614A1 (es) |
WO (1) | WO1991005855A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705732A (en) * | 1989-06-12 | 1998-01-06 | Oklahoma Medical Research Foundation | Universal donor cells |
EP0483247A4 (en) * | 1989-07-21 | 1992-12-09 | Washington University | Recombinantly produced human membrane cofactor protein (mcp) |
WO1991018097A1 (en) * | 1990-05-11 | 1991-11-28 | University Of Melbourne | Cd46 variants |
US5846715A (en) * | 1990-05-11 | 1998-12-08 | The Austin Research Institute | CD46 variants |
DE69233010T2 (de) * | 1991-07-15 | 2004-02-19 | Oklahoma Medical Research Foundation, Oklahoma | Universale spenderzellen |
US6916654B1 (en) * | 1992-06-29 | 2005-07-12 | Oklahoma Medical Research Foundation | Universal donor cells |
JPH08501451A (ja) * | 1992-09-22 | 1996-02-20 | ディーエヌエックス バイオセラピューティックス、インコーポレーテッド | 異種移植臓器移植片の事前適応化、その他を目的とする膜間転移によるタンパク質の供給法 |
US5627264A (en) * | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
JPH10507906A (ja) * | 1994-08-19 | 1998-08-04 | ザ ジェネラル ホスピタル コーポレイション | 遺伝子工学処理したブタ細胞 |
WO1997006241A1 (en) * | 1995-08-04 | 1997-02-20 | The General Hospital Corporation | Transgenic swine and swine cells having human hla genes |
US6166288A (en) * | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
AU1933897A (en) * | 1996-03-22 | 1997-10-17 | Imutran Limited | Surfaces which prevent or reduce complement activation |
EP1676920B1 (en) | 1997-03-26 | 2014-07-09 | Imperial Innovations Limited | Anticoagulant fusion protein anchored to cell membrane |
EP1004238B1 (en) | 1997-07-14 | 2005-12-21 | Nippon Meat Packers, Inc. | Transgenic pigs |
DE69828615T2 (de) * | 1997-10-31 | 2005-12-01 | Walter Reed Army Institute Of Research | Verwendung von inhibitoren der komplementaktivierung zur herstellung eines medikaments zur inhibierung von nebenwirkungen von pharmazeutischen zusammensetzungen, die amphiphile träger oder wirkstoffträger moleküle enthalten |
SE523817C2 (sv) | 1999-02-05 | 2004-05-18 | Corline Systems Ab | Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler |
GB9905503D0 (en) | 1999-03-10 | 1999-05-05 | Adprotech Plc | Novel compound formulations and methods of delivery |
WO2005009134A1 (en) | 2003-07-21 | 2005-02-03 | Lifecell Corporation | ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE |
EP2464219B1 (en) | 2009-08-14 | 2019-10-23 | Revivicor, Inc. | Multi-transgenic pigs for diabetes treatment |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
SG10201506959SA (en) | 2010-09-03 | 2015-10-29 | Stemcentrx Inc | Novel modulators and methods of use |
ES2680636T3 (es) | 2011-02-14 | 2018-09-10 | Revivicor Inc. | Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos |
AU2014341866B2 (en) | 2013-11-04 | 2018-07-05 | Lifecell Corporation | Methods of removing alpha-galactose |
CN114686427B (zh) * | 2022-05-23 | 2022-07-29 | 中国人民解放军总医院第一医学中心 | 一种脾脏调节型b淋巴细胞及其制备方法与应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0081570A4 (en) * | 1981-06-12 | 1985-09-02 | Univ Ohio | GENETIC TRANSFORMATION OF ZYGOTS. |
US4431636A (en) | 1982-05-24 | 1984-02-14 | American Cyanamid Company | Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use |
US5109113A (en) * | 1986-05-02 | 1992-04-28 | Genentech, Inc. | Membrane anchor fusion polypeptides |
JPS62104594A (ja) * | 1985-10-31 | 1987-05-15 | Terumo Corp | クエン酸塩利用能検査用培地組成物 |
JPH0742235B2 (ja) * | 1985-11-08 | 1995-05-10 | 三共株式会社 | 自己免疫性疾病の予防・治療剤 |
IL82390A0 (en) * | 1986-05-02 | 1987-10-30 | Genentech Inc | Nucleic acid and methods for the synthesis of novel daf compositions |
GB8615942D0 (en) * | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
IL89790A (en) * | 1988-04-01 | 2002-05-23 | Johns Hopking University | Sequences of nucleic acids encoding and cells producing CR1 protein and methods for its production and purification |
DE3830271A1 (de) | 1988-09-06 | 1990-03-15 | Goetze Otto | Mittel mit immunsuppressiver wirkung |
US5573940A (en) * | 1989-06-12 | 1996-11-12 | Oklahoma Medical Research Foundation | Cells expressing high levels of CD59 |
-
1990
- 1990-10-12 CN CN90108275A patent/CN1122719C/zh not_active Expired - Fee Related
- 1990-10-12 SG SG1996001903A patent/SG72614A1/en unknown
- 1990-10-12 IE IE364990A patent/IE75345B1/en not_active IP Right Cessation
- 1990-10-12 MY MYPI90001781A patent/MY107433A/en unknown
- 1990-10-12 DK DK90915320.7T patent/DK0495852T3/da active
- 1990-10-12 AU AU65392/90A patent/AU654116B2/en not_active Ceased
- 1990-10-12 JP JP51427990A patent/JP3302358B2/ja not_active Ceased
- 1990-10-12 NZ NZ248153A patent/NZ248153A/en unknown
- 1990-10-12 CN CNA021302499A patent/CN1491624A/zh active Pending
- 1990-10-12 EP EP95118520A patent/EP0709459A3/en not_active Withdrawn
- 1990-10-12 RO RO92-200502A patent/RO109863B1/ro unknown
- 1990-10-12 AT AT90915320T patent/ATE139562T1/de not_active IP Right Cessation
- 1990-10-12 DE DE69027535T patent/DE69027535T2/de not_active Expired - Fee Related
- 1990-10-12 NZ NZ235657A patent/NZ235657A/en unknown
- 1990-10-12 WO PCT/GB1990/001575 patent/WO1991005855A1/en active Application Filing
- 1990-10-12 CA CA002067235A patent/CA2067235A1/en not_active Abandoned
- 1990-10-12 HU HU9201240A patent/HUT64584A/hu unknown
- 1990-10-12 PT PT95580A patent/PT95580B/pt not_active IP Right Cessation
- 1990-10-12 ES ES90915320T patent/ES2060561T3/es not_active Expired - Lifetime
- 1990-10-12 DE DE90915320T patent/DE495852T1/de active Pending
- 1990-10-12 EP EP90915320A patent/EP0495852B1/en not_active Expired - Lifetime
- 1990-10-12 KR KR1019920700843A patent/KR920702410A/ko not_active Application Discontinuation
- 1990-10-12 IL IL95970A patent/IL95970A0/xx unknown
- 1990-10-12 KR KR1019997005897A patent/KR100317106B1/ko not_active IP Right Cessation
- 1990-10-12 IN IN872/CAL/90A patent/IN171948B/en unknown
-
1992
- 1992-04-10 FI FI921618A patent/FI921618A/fi not_active Application Discontinuation
- 1992-04-10 NO NO921438A patent/NO303502B1/no active IP Right Review Request
- 1992-05-12 BG BG96329A patent/BG61080B1/bg unknown
-
1994
- 1994-02-28 GR GR940300004T patent/GR940300004T1/el unknown
- 1994-11-21 US US08/347,210 patent/US6495735B1/en not_active Expired - Lifetime
-
1996
- 1996-07-15 PT PT101896A patent/PT101896B/pt not_active IP Right Cessation
- 1996-08-07 GR GR960402106T patent/GR3020741T3/el unknown
-
1997
- 1997-04-17 HK HK48497A patent/HK48497A/xx not_active IP Right Cessation
- 1997-05-07 IL IL12079597A patent/IL120795A0/xx unknown
- 1997-09-05 CY CY199697A patent/CY1996A/xx unknown
-
1998
- 1998-05-11 NO NO982131A patent/NO982131D0/no unknown
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