PT101896B - MATERIAL BIOLóGICO MODIFICADO, NOMEADAMENTE UM ANIMAL TRANSGéNICO, E MéTODO DE TRANSPLANTE, DE TECIDO ANIMAL - Google Patents

MATERIAL BIOLóGICO MODIFICADO, NOMEADAMENTE UM ANIMAL TRANSGéNICO, E MéTODO DE TRANSPLANTE, DE TECIDO ANIMAL

Info

Publication number
PT101896B
PT101896B PT101896A PT10189696A PT101896B PT 101896 B PT101896 B PT 101896B PT 101896 A PT101896 A PT 101896A PT 10189696 A PT10189696 A PT 10189696A PT 101896 B PT101896 B PT 101896B
Authority
PT
Portugal
Prior art keywords
animal
species
addition
rejection
biological material
Prior art date
Application number
PT101896A
Other languages
English (en)
Other versions
PT101896A (pt
Inventor
David James Graham White
Alan Frederick Williams
Original Assignee
Imutran Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26296038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT101896(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB898922987A external-priority patent/GB8922987D0/en
Priority claimed from GB909017198A external-priority patent/GB9017198D0/en
Application filed by Imutran Ltd filed Critical Imutran Ltd
Publication of PT101896A publication Critical patent/PT101896A/pt
Publication of PT101896B publication Critical patent/PT101896B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
PT101896A 1989-10-12 1996-07-15 MATERIAL BIOLóGICO MODIFICADO, NOMEADAMENTE UM ANIMAL TRANSGéNICO, E MéTODO DE TRANSPLANTE, DE TECIDO ANIMAL PT101896B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898922987A GB8922987D0 (en) 1989-10-12 1989-10-12 Modified biological material
GB909017198A GB9017198D0 (en) 1990-08-06 1990-08-06 Modified biological material

Publications (2)

Publication Number Publication Date
PT101896A PT101896A (pt) 1998-02-27
PT101896B true PT101896B (pt) 2003-01-31

Family

ID=26296038

Family Applications (2)

Application Number Title Priority Date Filing Date
PT95580A PT95580B (pt) 1989-10-12 1990-10-12 Processo para a preparacao de material biologico modificado
PT101896A PT101896B (pt) 1989-10-12 1996-07-15 MATERIAL BIOLóGICO MODIFICADO, NOMEADAMENTE UM ANIMAL TRANSGéNICO, E MéTODO DE TRANSPLANTE, DE TECIDO ANIMAL

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT95580A PT95580B (pt) 1989-10-12 1990-10-12 Processo para a preparacao de material biologico modificado

Country Status (27)

Country Link
US (1) US6495735B1 (pt)
EP (2) EP0709459A3 (pt)
JP (1) JP3302358B2 (pt)
KR (2) KR100317106B1 (pt)
CN (2) CN1491624A (pt)
AT (1) ATE139562T1 (pt)
AU (1) AU654116B2 (pt)
BG (1) BG61080B1 (pt)
CA (1) CA2067235A1 (pt)
CY (1) CY1996A (pt)
DE (2) DE69027535T2 (pt)
DK (1) DK0495852T3 (pt)
ES (1) ES2060561T3 (pt)
FI (1) FI921618A0 (pt)
GR (2) GR940300004T1 (pt)
HK (1) HK48497A (pt)
HU (1) HUT64584A (pt)
IE (1) IE75345B1 (pt)
IL (2) IL95970A0 (pt)
IN (1) IN171948B (pt)
MY (1) MY107433A (pt)
NO (2) NO303502B1 (pt)
NZ (2) NZ235657A (pt)
PT (2) PT95580B (pt)
RO (1) RO109863B1 (pt)
SG (1) SG72614A1 (pt)
WO (1) WO1991005855A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705732A (en) * 1989-06-12 1998-01-06 Oklahoma Medical Research Foundation Universal donor cells
AU651068B2 (en) * 1989-07-21 1994-07-14 Washington University Recombinantly produced human membrane cofactor protein (MCP)
US5846715A (en) * 1990-05-11 1998-12-08 The Austin Research Institute CD46 variants
EP0537171B1 (en) * 1990-05-11 2002-09-18 The Austin Research Institute CD46 isoforms
EP0591462B1 (en) * 1991-07-15 2003-04-16 Oklahoma Medical Research Foundation Universal donor cells
US6916654B1 (en) * 1992-06-29 2005-07-12 Oklahoma Medical Research Foundation Universal donor cells
CA2144767A1 (en) * 1992-09-22 1994-03-31 Guerard W. Byrne Delivery of proteins by intermembrane transfer for preaccommodation of xenogeneic organ transplants and other purposes
US5627264A (en) * 1994-03-03 1997-05-06 Alexion Pharmaceuticals, Inc. Chimeric complement inhibitor proteins
JPH10507906A (ja) * 1994-08-19 1998-08-04 ザ ジェネラル ホスピタル コーポレイション 遺伝子工学処理したブタ細胞
WO1997006241A1 (en) 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU1933897A (en) * 1996-03-22 1997-10-17 Imutran Limited Surfaces which prevent or reduce complement activation
EP1000161B1 (en) 1997-03-26 2006-02-22 Imperial College Innovations Limited Anticoagulant fusion protein anchored to cell membrane
DE69832883T2 (de) 1997-07-14 2006-08-24 Nippon Meat Packers, Inc. Transgene schweine
AU1297899A (en) * 1997-10-31 1999-05-24 Walter Reed Army Institute Of Research Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
SE523817C2 (sv) * 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
GB9905503D0 (en) 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
CA2533259C (en) 2003-07-21 2014-01-28 Lifecell Corporation Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue
AU2010282239A1 (en) 2009-08-14 2012-03-08 Revivicor, Inc. Multi-transgenic pigs for diabetes treatment
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
SG10201506959SA (en) 2010-09-03 2015-10-29 Stemcentrx Inc Novel modulators and methods of use
CN103492576A (zh) 2011-02-14 2014-01-01 雷维维科公司 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪
EP3799893A1 (en) 2013-11-04 2021-04-07 LifeCell Corporation Methods of removing alpha-galactose
CN114686427B (zh) * 2022-05-23 2022-07-29 中国人民解放军总医院第一医学中心 一种脾脏调节型b淋巴细胞及其制备方法与应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081570A4 (en) * 1981-06-12 1985-09-02 Univ Ohio GENETIC TRANSFORMATION OF ZYGOTS.
US4431636A (en) 1982-05-24 1984-02-14 American Cyanamid Company Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
US5109113A (en) * 1986-05-02 1992-04-28 Genentech, Inc. Membrane anchor fusion polypeptides
JPS62104594A (ja) * 1985-10-31 1987-05-15 Terumo Corp クエン酸塩利用能検査用培地組成物
JPH0742235B2 (ja) * 1985-11-08 1995-05-10 三共株式会社 自己免疫性疾病の予防・治療剤
IL82390A0 (en) * 1986-05-02 1987-10-30 Genentech Inc Nucleic acid and methods for the synthesis of novel daf compositions
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
IL89790A (en) * 1988-04-01 2002-05-23 Johns Hopking University Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification
DE3830271A1 (de) 1988-09-06 1990-03-15 Goetze Otto Mittel mit immunsuppressiver wirkung
US5573940A (en) * 1989-06-12 1996-11-12 Oklahoma Medical Research Foundation Cells expressing high levels of CD59

Also Published As

Publication number Publication date
EP0495852A1 (en) 1992-07-29
KR920702410A (ko) 1992-09-04
CA2067235A1 (en) 1991-04-13
HUT64584A (en) 1994-01-28
NO921438D0 (no) 1992-04-10
CN1491624A (zh) 2004-04-28
CY1996A (en) 1997-09-05
ES2060561T3 (es) 1996-08-01
GR3020741T3 (en) 1996-11-30
NO303502B1 (no) 1998-07-20
ATE139562T1 (de) 1996-07-15
NO921438L (no) 1992-04-10
DE69027535D1 (de) 1996-07-25
NO982131D0 (no) 1998-05-11
KR100317106B1 (ko) 2001-12-22
EP0709459A3 (en) 1999-01-07
BG96329A (bg) 1993-12-24
DE495852T1 (de) 1994-03-31
AU654116B2 (en) 1994-10-27
SG72614A1 (en) 2000-05-23
FI921618L (fi) 1992-04-10
CN1122719C (zh) 2003-10-01
HU9201240D0 (en) 1992-06-29
FI921618A7 (fi) 1992-04-10
ES2060561T1 (es) 1994-12-01
MY107433A (en) 1995-12-30
PT95580A (pt) 1991-09-13
IN171948B (pt) 1993-02-13
RO109863B1 (ro) 1995-06-30
EP0495852B1 (en) 1996-06-19
JP3302358B2 (ja) 2002-07-15
BG61080B1 (bg) 1996-10-31
NO982131L (no) 1992-04-10
NZ235657A (en) 1994-05-26
AU6539290A (en) 1991-05-16
PT95580B (pt) 1999-05-31
PT101896A (pt) 1998-02-27
FI921618A0 (fi) 1992-04-10
GR940300004T1 (en) 1994-02-28
IE75345B1 (en) 1997-08-27
HK48497A (en) 1997-04-25
EP0709459A2 (en) 1996-05-01
DK0495852T3 (da) 1996-07-15
DE69027535T2 (de) 1996-11-28
NZ248153A (en) 1997-07-27
IL95970A0 (en) 1992-05-25
IL120795A0 (en) 1997-09-30
JPH05503074A (ja) 1993-05-27
IE903649A1 (en) 1991-04-24
WO1991005855A1 (en) 1991-05-02
CN1051199A (zh) 1991-05-08
US6495735B1 (en) 2002-12-17

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