CN112135827B - 盐、晶型及其制备方法 - Google Patents

盐、晶型及其制备方法 Download PDF

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Publication number
CN112135827B
CN112135827B CN201980026160.4A CN201980026160A CN112135827B CN 112135827 B CN112135827 B CN 112135827B CN 201980026160 A CN201980026160 A CN 201980026160A CN 112135827 B CN112135827 B CN 112135827B
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CN
China
Prior art keywords
pyran
dihydro
thieno
methyl
tpma
Prior art date
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CN201980026160.4A
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English (en)
Chinese (zh)
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CN112135827A (zh
Inventor
安德里亚·鲍尔
南德库马尔·N·伯格尔
陈晓霞
沙赫拉·贾姆扎德
罗伯特·约瑟夫·普里克
卡斯达·S
哈罗德·斯科特·威尔金森
张海涛
迈克尔·约瑟夫·西森斯基
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Sumitomo Pharma America Inc
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Sunovion Pharmaceuticals Inc
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Priority to CN202311847631.2A priority Critical patent/CN118406063A/zh
Publication of CN112135827A publication Critical patent/CN112135827A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201980026160.4A 2018-02-16 2019-02-15 盐、晶型及其制备方法 Active CN112135827B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311847631.2A CN118406063A (zh) 2018-02-16 2019-02-15 盐、晶型及其制备方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862710416P 2018-02-16 2018-02-16
US62/710,416 2018-02-16
PCT/US2019/018265 WO2019161238A1 (en) 2018-02-16 2019-02-15 Salts, crystal forms, and production methods thereof

Related Child Applications (1)

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CN202311847631.2A Division CN118406063A (zh) 2018-02-16 2019-02-15 盐、晶型及其制备方法

Publications (2)

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CN112135827A CN112135827A (zh) 2020-12-25
CN112135827B true CN112135827B (zh) 2024-01-12

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CN202311847631.2A Pending CN118406063A (zh) 2018-02-16 2019-02-15 盐、晶型及其制备方法

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US (4) US10815249B2 (https=)
EP (1) EP3752508A1 (https=)
JP (2) JP7453148B2 (https=)
KR (1) KR102746817B1 (https=)
CN (2) CN112135827B (https=)
AU (2) AU2019222491B2 (https=)
CA (1) CA3091292A1 (https=)
EA (1) EA202091945A1 (https=)
IL (3) IL285739B2 (https=)
MX (2) MX2020008537A (https=)
MY (1) MY208150A (https=)
PH (1) PH12020551256A1 (https=)
SG (1) SG11202007823PA (https=)
UA (1) UA130249C2 (https=)
WO (1) WO2019161238A1 (https=)

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CN106883246B (zh) 2009-12-04 2020-05-29 桑诺维恩药品公司 多环化合物及其使用方法
CA3032141A1 (en) 2016-07-29 2018-02-01 Vadim ALEXANDROV Compounds and compositions and uses thereof
IL268694B2 (en) 2017-02-16 2023-10-01 Sunovion Pharmaceuticals Inc Treatment of schizophrenia
BR112020001433A2 (pt) 2017-08-02 2020-07-28 Sunovion Pharmaceuticals Inc. compostos de isocromano e usos dos mesmos
EA202091945A1 (ru) 2018-02-16 2021-01-18 Суновион Фармасьютикалз Инк. Соли, кристаллические формы и способы их получения
CN118576586A (zh) 2018-12-06 2024-09-03 住友制药美国公司 治疗神经和精神疾病的方法
CN115734785A (zh) * 2020-04-14 2023-03-03 桑诺维恩药品公司 (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症
US12492213B2 (en) 2020-09-16 2025-12-09 Assia Chemical Industries Ltd. Solid state forms of sep-363856 and process for preparation thereof
WO2023049721A1 (en) 2021-09-23 2023-03-30 Sunovion Pharmaceuticals Inc. Methods of treating metabolic disorders
EP4580615A1 (en) 2022-08-30 2025-07-09 Sumitomo Pharma America, Inc. Ulotaront for the adjuvant treatment of major depressive disorder
AU2023358704A1 (en) 2022-10-13 2025-05-29 Sumitomo Pharma America, Inc. Methods of reducing physical dependence to neuropsychiatric treatments
TW202421114A (zh) 2022-10-28 2024-06-01 美商住友製藥美國公司 治療焦慮及相關病狀之方法
CN120187422A (zh) 2022-11-15 2025-06-20 住友制药美国公司 使用ulotaront转换神经精神病学药物的方法
WO2025175067A1 (en) 2024-02-16 2025-08-21 Sumitomo Pharma America, Inc. Methods of administering the neuropsychiatric medication ulotaront based on renal impairment
TW202600129A (zh) 2024-02-23 2026-01-01 美商住友製藥美國公司 烏洛托隆（ulotaront）鹽酸鹽的製造方法

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CN102762575A (zh) * 2009-12-04 2012-10-31 桑诺维恩药品公司 多环化合物及其使用方法

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