AU2019222491B2 - Salts, crystal forms, and production methods thereof - Google Patents

Salts, crystal forms, and production methods thereof Download PDF

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Publication number
AU2019222491B2
AU2019222491B2 AU2019222491A AU2019222491A AU2019222491B2 AU 2019222491 B2 AU2019222491 B2 AU 2019222491B2 AU 2019222491 A AU2019222491 A AU 2019222491A AU 2019222491 A AU2019222491 A AU 2019222491A AU 2019222491 B2 AU2019222491 B2 AU 2019222491B2
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AU
Australia
Prior art keywords
thieno
pyran
dihydro
tpma
crystalline
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AU2019222491A
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AU2019222491A1 (en
Inventor
Andrea Bauer
Nandkumar Nivritti BHOGLE
Xiaoxia Chen
Shahla Jamzad
Robert Joseph PRYTKO
Kostas Saranteas
Michael Joseph Sizensky
Harold Scott Wilkinson
Haitao Zhang
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Sumitomo Pharma America Inc
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Sumitomo Pharma America Inc
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Publication of AU2019222491A1 publication Critical patent/AU2019222491A1/en
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Priority to AU2023202174A priority Critical patent/AU2023202174B2/en
Assigned to SUMITOMO PHARMA AMERICA, INC. reassignment SUMITOMO PHARMA AMERICA, INC. Request for Assignment Assignors: SUNOVION PHARMACEUTICALS INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2019222491A 2018-02-16 2019-02-15 Salts, crystal forms, and production methods thereof Active AU2019222491B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023202174A AU2023202174B2 (en) 2018-02-16 2023-04-11 Salts, crystal forms, and production methods thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862710416P 2018-02-16 2018-02-16
US62/710,416 2018-02-16
PCT/US2019/018265 WO2019161238A1 (en) 2018-02-16 2019-02-15 Salts, crystal forms, and production methods thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023202174A Division AU2023202174B2 (en) 2018-02-16 2023-04-11 Salts, crystal forms, and production methods thereof

Publications (2)

Publication Number Publication Date
AU2019222491A1 AU2019222491A1 (en) 2020-09-10
AU2019222491B2 true AU2019222491B2 (en) 2023-01-12

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AU2019222491A Active AU2019222491B2 (en) 2018-02-16 2019-02-15 Salts, crystal forms, and production methods thereof
AU2023202174A Active AU2023202174B2 (en) 2018-02-16 2023-04-11 Salts, crystal forms, and production methods thereof

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Country Status (15)

Country Link
US (4) US10815249B2 (https=)
EP (1) EP3752508A1 (https=)
JP (2) JP7453148B2 (https=)
KR (1) KR102746817B1 (https=)
CN (2) CN118406063A (https=)
AU (2) AU2019222491B2 (https=)
CA (1) CA3091292A1 (https=)
EA (1) EA202091945A1 (https=)
IL (3) IL285739B2 (https=)
MX (2) MX2020008537A (https=)
MY (1) MY208150A (https=)
PH (1) PH12020551256A1 (https=)
SG (1) SG11202007823PA (https=)
UA (1) UA130249C2 (https=)
WO (1) WO2019161238A1 (https=)

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SG10201510665WA (en) 2009-12-04 2016-01-28 Sunovion Pharmaceuticals Inc Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
MX390141B (es) 2017-02-16 2025-03-20 Sunovion Pharmaceuticals Inc Metodos para tratar esquizofrenia
CA3070993C (en) 2017-08-02 2025-05-20 Sunovion Pharmaceuticals Inc. ISOCHROMANE COMPOUNDS AND THEIR USES
UA130249C2 (uk) 2018-02-16 2025-12-31 Сумітомо Фарма Америка, Інк. Солі, кристалічні форми і способи їх отримання
US20200179336A1 (en) 2018-12-06 2020-06-11 Sunovion Pharmaceuticals Inc. Methods of treating neurological and psychiatric disorders
CA3180115A1 (en) 2020-04-14 2021-10-21 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
US12492213B2 (en) 2020-09-16 2025-12-09 Assia Chemical Industries Ltd. Solid state forms of sep-363856 and process for preparation thereof
AU2022348905A1 (en) 2021-09-23 2024-04-11 Sumitomo Pharma America, Inc. Methods of treating metabolic disorders
CA3260160A1 (en) 2022-08-30 2024-03-07 Sumitomo Pharma America, Inc. ULOTARONT FOR THE ADJUVANT TREATMENT OF MAJOR DEPRESSIVE DISORDER
AU2023358704A1 (en) 2022-10-13 2025-05-29 Sumitomo Pharma America, Inc. Methods of reducing physical dependence to neuropsychiatric treatments
KR20250088777A (ko) 2022-10-28 2025-06-17 스미토모 파마 아메리카, 인크. 불안 및 연관된 상태를 치료하기 위한 울로타론트
WO2024107681A1 (en) 2022-11-15 2024-05-23 Sumitomo Pharma America, Inc. Methods of switching neuropsychiatric medications using ulotaront
US20250262185A1 (en) 2024-02-16 2025-08-21 Sumitomo Pharma America, Inc. Methods of administering neuropsychiatric medications based on renal impairment
TW202600129A (zh) 2024-02-23 2026-01-01 美商住友製藥美國公司 烏洛托隆（ulotaront）鹽酸鹽的製造方法

Citations (1)

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WO2011069063A2 (en) * 2009-12-04 2011-06-09 Sunovion Pharmaceuticals, Inc. Multicyclic compounds and methods of use thereof

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