CN112125884A - 制备嘧啶-2,4-二胺二盐酸盐的方法 - Google Patents

制备嘧啶-2,4-二胺二盐酸盐的方法 Download PDF

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Publication number
CN112125884A
CN112125884A CN202011050061.0A CN202011050061A CN112125884A CN 112125884 A CN112125884 A CN 112125884A CN 202011050061 A CN202011050061 A CN 202011050061A CN 112125884 A CN112125884 A CN 112125884A
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phenyl
pyrimidine
isopropoxy
methyl
piperidin
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Chinese (zh)
Inventor
B·宫
冯丽丽
P·H·卡平斯基
L·M·维科尔
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Hydrogenated Pyridines (AREA)
CN202011050061.0A 2010-12-17 2011-12-15 制备嘧啶-2,4-二胺二盐酸盐的方法 Pending CN112125884A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424194P 2010-12-17 2010-12-17
US61/424,194 2010-12-17
CN201180060435XA CN103282359A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式

Related Parent Applications (1)

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CN201180060435XA Division CN103282359A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式

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CN112125884A true CN112125884A (zh) 2020-12-25

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Application Number Title Priority Date Filing Date
CN202011050061.0A Pending CN112125884A (zh) 2010-12-17 2011-12-15 制备嘧啶-2,4-二胺二盐酸盐的方法
CN201710063793.5A Pending CN107056751A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式
CN201710063792.0A Pending CN106831716A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式
CN201180060435XA Pending CN103282359A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式
CN201410457562.9A Pending CN104262324A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式
CN202210792464.5A Pending CN114989139A (zh) 2010-12-17 2011-12-15 制备嘧啶-2,4-二胺二盐酸盐的方法
CN201610217386.0A Pending CN106008462A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式

Family Applications After (6)

Application Number Title Priority Date Filing Date
CN201710063793.5A Pending CN107056751A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式
CN201710063792.0A Pending CN106831716A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式
CN201180060435XA Pending CN103282359A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式
CN201410457562.9A Pending CN104262324A (zh) 2010-12-17 2011-12-15 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式
CN202210792464.5A Pending CN114989139A (zh) 2010-12-17 2011-12-15 制备嘧啶-2,4-二胺二盐酸盐的方法
CN201610217386.0A Pending CN106008462A (zh) 2010-12-17 2011-12-15 一种alk抑制剂的结晶形式

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US (2) US9309229B2 (OSRAM)
EP (3) EP3453708B8 (OSRAM)
JP (1) JP5916752B2 (OSRAM)
KR (4) KR20190022903A (OSRAM)
CN (7) CN112125884A (OSRAM)
AR (2) AR084309A1 (OSRAM)
AU (1) AU2011343775B2 (OSRAM)
BR (1) BR112013015000A2 (OSRAM)
CA (1) CA2821102C (OSRAM)
CL (1) CL2013001723A1 (OSRAM)
CO (1) CO6801792A2 (OSRAM)
CY (2) CY1119474T1 (OSRAM)
DK (2) DK3121171T3 (OSRAM)
EC (1) ECSP13012770A (OSRAM)
ES (3) ES2696526T3 (OSRAM)
GT (1) GT201300153A (OSRAM)
HR (2) HRP20171477T1 (OSRAM)
HU (1) HUE041845T2 (OSRAM)
IL (1) IL226474A (OSRAM)
LT (2) LT3121171T (OSRAM)
MA (1) MA34771B1 (OSRAM)
MX (1) MX338210B (OSRAM)
MY (2) MY177742A (OSRAM)
NZ (1) NZ610713A (OSRAM)
PE (1) PE20140698A1 (OSRAM)
PH (1) PH12013501254A1 (OSRAM)
PL (2) PL2651918T3 (OSRAM)
PT (2) PT3121171T (OSRAM)
RS (1) RS57771B1 (OSRAM)
RU (2) RU2746159C2 (OSRAM)
SG (2) SG10201510082XA (OSRAM)
SI (2) SI3121171T1 (OSRAM)
TN (1) TN2013000216A1 (OSRAM)
TW (2) TWI576343B (OSRAM)
WO (1) WO2012082972A1 (OSRAM)
ZA (1) ZA201303599B (OSRAM)

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KR102325775B1 (ko) 2021-11-12
PH12013501254A1 (en) 2016-07-29
CL2013001723A1 (es) 2013-12-27
AR122395A2 (es) 2022-09-07
RS57771B1 (sr) 2018-12-31
TN2013000216A1 (en) 2014-11-10
DK3121171T3 (en) 2018-12-10
MY164810A (en) 2018-01-30
TWI576344B (zh) 2017-04-01
US9309229B2 (en) 2016-04-12
JP5916752B2 (ja) 2016-05-11
CN106008462A (zh) 2016-10-12
LT3121171T (lt) 2018-11-12
CA2821102A1 (en) 2012-06-21
PT3121171T (pt) 2018-11-27
TW201307299A (zh) 2013-02-16
IL226474A (en) 2016-03-31
RU2016136823A (ru) 2018-12-11
DK2651918T3 (en) 2017-10-23
WO2012082972A1 (en) 2012-06-21
GT201300153A (es) 2014-06-09
MY177742A (en) 2020-09-23
PL2651918T3 (pl) 2017-12-29
HRP20181737T1 (hr) 2018-12-28
JP2013545812A (ja) 2013-12-26
ES2696526T3 (es) 2019-01-16
CN107056751A (zh) 2017-08-18
CY1119474T1 (el) 2018-04-04
EP2651918B1 (en) 2017-07-12
SG10201510082XA (en) 2016-01-28
EP2651918A1 (en) 2013-10-23
CA2821102C (en) 2019-06-11
MA34771B1 (fr) 2013-12-03
CN114989139A (zh) 2022-09-02
MX2013006952A (es) 2013-07-15
ES2643016T3 (es) 2017-11-21
BR112013015000A2 (pt) 2016-08-09
TWI576343B (zh) 2017-04-01
EP3453708B8 (en) 2022-03-16
SG190856A1 (en) 2013-07-31
RU2016136823A3 (OSRAM) 2020-02-06
CY1121017T1 (el) 2019-12-11
RU2746159C2 (ru) 2021-04-08
KR20180032680A (ko) 2018-03-30
PE20140698A1 (es) 2014-06-11
KR20190022903A (ko) 2019-03-06
US20130274279A1 (en) 2013-10-17
ZA201303599B (en) 2014-02-26
EP3453708A1 (en) 2019-03-13
US20160175305A1 (en) 2016-06-23
PL3121171T3 (pl) 2019-01-31
CN106831716A (zh) 2017-06-13
SI3121171T1 (sl) 2018-11-30
IL226474A0 (en) 2013-07-31
CO6801792A2 (es) 2013-11-29
ECSP13012770A (es) 2013-10-31
HUE041845T2 (hu) 2019-05-28
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