CN111699200B - 针对pd-1的单域抗体和其变体 - Google Patents

针对pd-1的单域抗体和其变体 Download PDF

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CN111699200B
CN111699200B CN201980012465.XA CN201980012465A CN111699200B CN 111699200 B CN111699200 B CN 111699200B CN 201980012465 A CN201980012465 A CN 201980012465A CN 111699200 B CN111699200 B CN 111699200B
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amino acid
seq
acid sequence
sdab
construct
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CN111699200A (zh
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张亚峰
武术
杨帅
周传初
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980012465.XA 2018-01-15 2019-01-15 针对pd-1的单域抗体和其变体 Active CN111699200B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018072589 2018-01-15
CNPCT/CN2018/072589 2018-01-15
PCT/CN2019/071691 WO2019137541A1 (en) 2018-01-15 2019-01-15 Single-domain antibodies and variants thereof against pd-1

Publications (2)

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CN111699200A CN111699200A (zh) 2020-09-22
CN111699200B true CN111699200B (zh) 2023-05-26

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US (1) US11713353B2 (https=)
EP (1) EP3740507A4 (https=)
JP (1) JP7366908B2 (https=)
KR (2) KR20250114571A (https=)
CN (1) CN111699200B (https=)
AU (2) AU2019207276B2 (https=)
CA (2) CA3264983A1 (https=)
IL (1) IL275740A (https=)
SG (1) SG11202004233UA (https=)
TW (1) TWI802633B (https=)
WO (1) WO2019137541A1 (https=)

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CN109705211B (zh) 2017-10-26 2020-08-18 苏州复融生物技术有限公司 一种IgG1 Fc单体及其应用
CN111699200B (zh) 2018-01-15 2023-05-26 南京传奇生物科技有限公司 针对pd-1的单域抗体和其变体
US12358987B2 (en) * 2019-07-08 2025-07-15 Nanjing GenScript Biotech Co., Ltd. Anti-CD47/anti-PD-1 bispecific antibody, preparation method and use thereof
WO2021043261A1 (zh) * 2019-09-06 2021-03-11 北京拓界生物医药科技有限公司 抗pd-1单域抗体、其衍生蛋白及其医药用途
CA3165927A1 (en) 2020-01-11 2021-07-15 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
CN115667307A (zh) * 2020-05-20 2023-01-31 居里研究所 合成的单域文库
CN112341538A (zh) * 2020-10-27 2021-02-09 苏州复融生物技术有限公司 一种Fc单体多肽及其应用
CN114685655B (zh) * 2020-12-28 2024-04-12 浙江纳米抗体技术中心有限公司 Pd-1结合分子及其应用
CN114763384B (zh) * 2021-01-14 2023-03-17 立凌生物制药(苏州)有限公司 靶向pd-1的单域抗体及其衍生物和用途
JP7694922B2 (ja) * 2021-01-29 2025-06-18 ミンフィ ファーマシューティカル （ハンチョウ） リミテッド 抗原結合タンパク質およびその使用
CN114573704B (zh) * 2021-03-10 2022-11-01 北京拓界生物医药科技有限公司 Pd-1/ctla-4结合蛋白及其医药用途
JP2024517558A (ja) 2021-04-30 2024-04-23 メディミューン，エルエルシー 二重特異性ｐｄ－１及びｔｉｇｉｔ結合タンパク質並びにその使用
CN115340605A (zh) * 2021-05-14 2022-11-15 迈威(上海)生物科技股份有限公司 一种抗pd-l1单域抗体及其衍生蛋白
EP4349867A4 (en) * 2021-05-28 2026-01-07 Harbour Biomed Shanghai Co Ltd SPECIFIC BINDING PROTEIN TARGETING PD-L1 AND CD73
JPWO2023100944A1 (https=) * 2021-12-01 2023-06-08
WO2024119193A2 (en) 2022-12-02 2024-06-06 AskGene Pharma, Inc. Mutant il-2 polypeptides and il-2 prodrugs
PE20252392A1 (es) 2022-12-12 2025-10-10 Lanova Medicines Ltd Anticuerpos biespecificos que se dirigen a pd1 y vegf
WO2025016011A1 (en) * 2023-07-14 2025-01-23 Genor Biopharma Co., Ltd. Anti-PD-1/CTLA-4/VEGF ANTIBODIES AND USE THEREOF
CN119930817B (zh) * 2024-12-24 2025-12-02 国科大杭州高等研究院 Tigit全人源抗体及其制备方法与应用
CN119638838B (zh) * 2025-02-17 2025-07-04 百吉生物医药(广州)股份有限公司 一种抗程序化死亡分子1的纳米抗体及其应用

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CN106715469A (zh) * 2014-08-27 2017-05-24 纪念斯隆-凯特琳癌症中心 抗体、组合物和用途

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