CN1113892C - 2’－氟－5－甲基－β－L－阿糖呋喃尿苷的制备方法 - Google Patents

2’－氟－5－甲基－β－L－阿糖呋喃尿苷的制备方法 Download PDF

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Publication number
CN1113892C
CN1113892C CN97116278A CN97116278A CN1113892C CN 1113892 C CN1113892 C CN 1113892C CN 97116278 A CN97116278 A CN 97116278A CN 97116278 A CN97116278 A CN 97116278A CN 1113892 C CN1113892 C CN 1113892C
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China
Prior art keywords
formula
compound
reaction
methyl
aryl
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Expired - Lifetime
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CN97116278A
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English (en)
Chinese (zh)
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CN1206012A (zh
Inventor
朱重光
社锦发
崔容硕
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University of Georgia Research Foundation Inc
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University of Georgia Research Foundation Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN97116278A 1997-07-23 1997-09-08 2’－氟－5－甲基－β－L－阿糖呋喃尿苷的制备方法 Expired - Lifetime CN1113892C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5348897P 1997-07-23 1997-07-23
US60/053488 1997-07-23
US60/053,488 1997-07-23

Publications (2)

Publication Number Publication Date
CN1206012A CN1206012A (zh) 1999-01-27
CN1113892C true CN1113892C (zh) 2003-07-09

Family

ID=21984622

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97116278A Expired - Lifetime CN1113892C (zh) 1997-07-23 1997-09-08 2’－氟－5－甲基－β－L－阿糖呋喃尿苷的制备方法

Country Status (21)

Country Link
US (2) US6512107B2 (enExample)
EP (2) EP1327637B1 (enExample)
KR (1) KR100247505B1 (enExample)
CN (1) CN1113892C (enExample)
AR (1) AR009092A1 (enExample)
AT (2) ATE304547T1 (enExample)
AU (1) AU8758298A (enExample)
BR (1) BR9810804B1 (enExample)
DE (2) DE69812959T2 (enExample)
DK (1) DK1327637T3 (enExample)
ES (2) ES2249678T3 (enExample)
ID (1) ID20624A (enExample)
IL (1) IL121730A (enExample)
IN (1) IN186807B (enExample)
MY (1) MY117314A (enExample)
PT (2) PT998482E (enExample)
SA (1) SA98180771B1 (enExample)
SI (1) SI1327637T1 (enExample)
TR (1) TR199701051A2 (enExample)
TW (1) TW434252B (enExample)
WO (2) WO1999005157A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
ES2243726T3 (es) * 2001-03-30 2005-12-01 Gilead Sciences, Inc. Procedimiento de preparacion de 2'-halo-beta-l-arabinofuranosil nucleosidos.
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
WO2003053360A2 (en) * 2001-12-20 2003-07-03 Pharmassett Ltd. Treatment of ebv and khsv infection and associated abnormal cellular proliferation
KR100976778B1 (ko) 2003-04-17 2010-08-18 부광약품 주식회사 1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
BRPI0515279A (pt) 2004-09-14 2008-07-15 Pharmasset Inc preparação de ribofuranosil pirimidinas e purinas 2'fluoro-2'-alquil- substituìdas ou outras opcionalmente substituìdas e seus derivados
NZ563686A (en) 2005-06-07 2011-07-29 Univ Yale Methods of treating cancer and other conditions or disease states using LFMAU and LDT
USRE45004E1 (en) 2007-06-18 2014-07-08 Sunshine Lake Pharma Co., Ltd. Bromo-phenyl substituted thiazolyl dihydropyrimidines
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
PE20210367A1 (es) 2018-02-02 2021-02-26 Maverix Oncology Inc Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina
CN109320564B (zh) * 2018-10-26 2022-05-31 浙江晟格生物科技有限公司 一种l-来苏糖的制备工艺
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺
CN109467541A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种绿色合成克拉夫定药物中间体的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1143966A (zh) * 1994-01-28 1997-02-26 佐治亚州大学研究基金会有限公司 治疗b型肝炎病毒和非洲淋巴细胞瘤病毒的l-核苷
JP3044397B2 (ja) * 1990-01-31 2000-05-22 バイエル・アクチエンゲゼルシヤフト 水性ポリマー分散物の混合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714473A1 (de) * 1987-04-30 1988-11-10 Basf Ag Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
EP0400064B1 (en) 1988-02-09 1993-04-21 Uop Solid catalysts for continuous interconversion of epimeric aldoses and aldose analogs
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3044397B2 (ja) * 1990-01-31 2000-05-22 バイエル・アクチエンゲゼルシヤフト 水性ポリマー分散物の混合物
CN1143966A (zh) * 1994-01-28 1997-02-26 佐治亚州大学研究基金会有限公司 治疗b型肝炎病毒和非洲淋巴细胞瘤病毒的l-核苷

Also Published As

Publication number Publication date
AR009092A1 (es) 2000-03-08
ES2195370T3 (es) 2003-12-01
TR199701051A3 (tr) 1999-03-22
TW434252B (en) 2001-05-16
US6894159B2 (en) 2005-05-17
SI1327637T1 (sl) 2005-12-31
EP1327637B1 (en) 2005-09-14
BR9810804A (pt) 2000-09-12
KR100247505B1 (ko) 2000-03-15
CN1206012A (zh) 1999-01-27
WO1999005157A1 (en) 1999-02-04
US20020062018A1 (en) 2002-05-23
US6512107B2 (en) 2003-01-28
ATE304547T1 (de) 2005-09-15
DE69812959T2 (de) 2004-03-04
TR199701051A2 (xx) 1999-03-22
ID20624A (id) 1999-01-28
MY117314A (en) 2004-06-30
SA98180771B1 (ar) 2006-10-29
US20030139593A1 (en) 2003-07-24
WO1999005158A1 (en) 1999-02-04
IN186807B (enExample) 2001-11-10
ATE236187T1 (de) 2003-04-15
DK1327637T3 (da) 2006-01-16
ES2249678T3 (es) 2006-04-01
EP0998482B1 (en) 2003-04-02
BR9810804B1 (pt) 2012-01-10
EP0998482A1 (en) 2000-05-10
DE69812959D1 (de) 2003-05-08
AU8758298A (en) 1999-02-16
IL121730A (en) 2005-03-20
IL121730A0 (en) 1998-02-22
KR19990013297A (ko) 1999-02-25
DE69831619T2 (de) 2006-06-14
PT998482E (pt) 2003-08-29
DE69831619D1 (de) 2005-10-20
EP1327637A1 (en) 2003-07-16
PT1327637E (pt) 2005-11-30

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Granted publication date: 20030709