DE69812959T2 - Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin - Google Patents

Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin Download PDF

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Publication number
DE69812959T2
DE69812959T2 DE69812959T DE69812959T DE69812959T2 DE 69812959 T2 DE69812959 T2 DE 69812959T2 DE 69812959 T DE69812959 T DE 69812959T DE 69812959 T DE69812959 T DE 69812959T DE 69812959 T2 DE69812959 T2 DE 69812959T2
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DE
Germany
Prior art keywords
formula
compound
give
acid
hydrogen
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812959T
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German (de)
English (en)
Other versions
DE69812959D1 (de
Inventor
K. Chung CHU
Yong S. Choi
Jinfa Du
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University of Georgia Research Foundation Inc
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University of Georgia Research Foundation Inc
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Publication of DE69812959D1 publication Critical patent/DE69812959D1/de
Application granted granted Critical
Publication of DE69812959T2 publication Critical patent/DE69812959T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69812959T 1997-07-23 1998-07-23 Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin Expired - Lifetime DE69812959T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5348897P 1997-07-23 1997-07-23
US53488P 1997-07-23
PCT/US1998/015375 WO1999005158A1 (en) 1997-07-23 1998-07-23 PROCESS FOR THE PREPARATION OF 2'-FLUORO-5-METHYL-β -L-ARABINOFURANOSYLURIDINE

Publications (2)

Publication Number Publication Date
DE69812959D1 DE69812959D1 (de) 2003-05-08
DE69812959T2 true DE69812959T2 (de) 2004-03-04

Family

ID=21984622

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69812959T Expired - Lifetime DE69812959T2 (de) 1997-07-23 1998-07-23 Verfahren zur herstellung von 2'-fluoro-5-methyl-beta-l-arabino-furanosyluridin
DE69831619T Expired - Lifetime DE69831619T2 (de) 1997-07-23 1998-07-23 Verfahren zur Herstellung von L-Ribose

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69831619T Expired - Lifetime DE69831619T2 (de) 1997-07-23 1998-07-23 Verfahren zur Herstellung von L-Ribose

Country Status (21)

Country Link
US (2) US6512107B2 (enExample)
EP (2) EP1327637B1 (enExample)
KR (1) KR100247505B1 (enExample)
CN (1) CN1113892C (enExample)
AR (1) AR009092A1 (enExample)
AT (2) ATE304547T1 (enExample)
AU (1) AU8758298A (enExample)
BR (1) BR9810804B1 (enExample)
DE (2) DE69812959T2 (enExample)
DK (1) DK1327637T3 (enExample)
ES (2) ES2249678T3 (enExample)
ID (1) ID20624A (enExample)
IL (1) IL121730A (enExample)
IN (1) IN186807B (enExample)
MY (1) MY117314A (enExample)
PT (2) PT998482E (enExample)
SA (1) SA98180771B1 (enExample)
SI (1) SI1327637T1 (enExample)
TR (1) TR199701051A2 (enExample)
TW (1) TW434252B (enExample)
WO (2) WO1999005157A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
IL158185A0 (en) * 2001-03-30 2004-03-28 Triangle Pharmaceuticals Inc PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
EP1569658A4 (en) * 2001-12-20 2007-05-30 Pharmassett Ltd TREATMENT OF EBV AND KHSV INFECTION AND AN ASSOCIATED ABNORMAL CELL PROLIFERATION
KR100976778B1 (ko) 2003-04-17 2010-08-18 부광약품 주식회사 1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
ES2725457T3 (es) 2004-09-14 2019-09-24 Gilead Pharmasset Llc Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
BRPI0613796A2 (pt) 2005-06-07 2011-02-15 Univ Yale composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt)
PT2514750E (pt) 2007-06-18 2014-01-23 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
CN109320564B (zh) * 2018-10-26 2022-05-31 浙江晟格生物科技有限公司 一种l-来苏糖的制备工艺
CN109467541A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种绿色合成克拉夫定药物中间体的方法
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714473A1 (de) * 1987-04-30 1988-11-10 Basf Ag Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
EP0400064B1 (en) 1988-02-09 1993-04-21 Uop Solid catalysts for continuous interconversion of epimeric aldoses and aldose analogs
DE4002727A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Mischungen aus waessrigen polymerdispersionen
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

Also Published As

Publication number Publication date
TR199701051A3 (tr) 1999-03-22
US6512107B2 (en) 2003-01-28
WO1999005158A1 (en) 1999-02-04
SA98180771B1 (ar) 2006-10-29
CN1113892C (zh) 2003-07-09
DE69812959D1 (de) 2003-05-08
DE69831619T2 (de) 2006-06-14
BR9810804B1 (pt) 2012-01-10
EP0998482B1 (en) 2003-04-02
KR100247505B1 (ko) 2000-03-15
DE69831619D1 (de) 2005-10-20
IL121730A0 (en) 1998-02-22
TR199701051A2 (xx) 1999-03-22
EP0998482A1 (en) 2000-05-10
KR19990013297A (ko) 1999-02-25
ES2249678T3 (es) 2006-04-01
TW434252B (en) 2001-05-16
ID20624A (id) 1999-01-28
PT1327637E (pt) 2005-11-30
BR9810804A (pt) 2000-09-12
EP1327637B1 (en) 2005-09-14
DK1327637T3 (da) 2006-01-16
SI1327637T1 (sl) 2005-12-31
AR009092A1 (es) 2000-03-08
US20020062018A1 (en) 2002-05-23
US6894159B2 (en) 2005-05-17
PT998482E (pt) 2003-08-29
AU8758298A (en) 1999-02-16
CN1206012A (zh) 1999-01-27
ATE304547T1 (de) 2005-09-15
IL121730A (en) 2005-03-20
MY117314A (en) 2004-06-30
IN186807B (enExample) 2001-11-10
US20030139593A1 (en) 2003-07-24
ES2195370T3 (es) 2003-12-01
WO1999005157A1 (en) 1999-02-04
ATE236187T1 (de) 2003-04-15
EP1327637A1 (en) 2003-07-16

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