CN111363041B - 新型抗-pd-l1抗体 - Google Patents
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- CN111363041B CN111363041B CN202010174431.5A CN202010174431A CN111363041B CN 111363041 B CN111363041 B CN 111363041B CN 202010174431 A CN202010174431 A CN 202010174431A CN 111363041 B CN111363041 B CN 111363041B
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| CN106243225B (zh) * | 2015-06-11 | 2021-01-19 | 智翔（上海）医药科技有限公司 | 新型抗-pd-l1抗体 |
| RU2744959C2 (ru) * | 2016-03-23 | 2021-03-17 | Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд | Новые анти-pd-l1 антитела |
| US10894823B2 (en) | 2016-03-24 | 2021-01-19 | Gensun Biopharma Inc. | Trispecific inhibitors for cancer treatment |
| CN109071656B (zh) | 2017-01-05 | 2021-05-18 | 璟尚生物制药公司 | 检查点调节物拮抗剂 |
| JP7021454B2 (ja) * | 2017-02-03 | 2022-02-17 | 株式会社三洋物産 | 遊技機 |
| EP3630838A1 (en) | 2017-06-01 | 2020-04-08 | CytomX Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| JP7402158B2 (ja) * | 2017-11-30 | 2023-12-20 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１抗体及びｐｄ－ｌ１を検出するためにそれを使用する方法 |
| CN109970857B (zh) * | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| CN111542543B (zh) | 2017-12-28 | 2023-12-22 | 南京传奇生物科技有限公司 | 针对pd-l1的抗体及其变体 |
| WO2019228514A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| WO2020006516A1 (en) | 2018-06-29 | 2020-01-02 | Gensun Biopharma, Inc. | Antitumor immune checkpoint regulator antagonists |
| CN112996910A (zh) * | 2018-07-11 | 2021-06-18 | 动量制药公司 | 与靶向PD-L1的工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| WO2020151572A1 (en) * | 2019-01-23 | 2020-07-30 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-l1 diabodies and the use thereof |
| US12421313B2 (en) | 2019-01-25 | 2025-09-23 | Chia Tia Tianqing Pharmaceutical Group Co., Ltd. | Combined pharmaceutical composition for treating tumor |
| CN109929037B (zh) * | 2019-04-01 | 2023-03-17 | 华博生物医药技术（上海）有限公司 | 针对程序性死亡配体的结合物及其应用 |
| CA3141531A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| JP2022534982A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| CN110194798A (zh) * | 2019-05-31 | 2019-09-03 | 杭州科兴生物科技有限公司 | 抗pd-l1单克隆抗体、片段及其医药用途 |
| WO2020263312A1 (en) | 2019-06-28 | 2020-12-30 | Gensun Biopharma, Inc. | ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFβ1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD |
| US20220356255A1 (en) * | 2019-07-15 | 2022-11-10 | Capella Bioscience Ltd | Anti-pd-l1 antibodies |
| US20230002492A1 (en) * | 2019-11-08 | 2023-01-05 | Simcere (Shanghai) Pharmaceutical Co., Ltd. | Anti-human programmed cell death ligand-1 (pd-l1) antibody and use thereof |
| WO2021197358A1 (zh) * | 2020-03-31 | 2021-10-07 | 普米斯生物技术(珠海)有限公司 | 一种抗pd-l1和pd-l2抗体及其衍生物和用途 |
| CN119462927B (zh) * | 2020-07-28 | 2025-07-29 | 乐普生物科技股份有限公司 | 靶向PD-L1和TGF-β的双功能分子 |
| CA3187850A1 (en) * | 2020-08-04 | 2022-02-10 | Bryan Glaser | Pd-l1 binding agents and uses thereof |
| CN111929447B (zh) * | 2020-09-24 | 2021-02-26 | 菁良基因科技(深圳)有限公司 | 一种pd-l1免疫组织化学参考品及其制备方法和应用 |
| CA3201518A1 (en) * | 2020-11-18 | 2022-05-27 | Suzhou Transcenta Therapeutics Co., Ltd. | Bi-functional molecules |
| CN112285366B (zh) * | 2020-12-25 | 2021-06-08 | 南京广祺医药科技有限公司 | 一种测定血清中双特异性抗体BsAb的ELISA方法及应用 |
| US20240352084A1 (en) | 2021-07-22 | 2024-10-24 | University Of Dundee | Therapeutic muteins |
| CN115521378B (zh) * | 2021-07-23 | 2023-12-22 | 南京吉盛澳玛生物医药有限公司 | Pd-l1抗体及其用途 |
| CN118215681A (zh) * | 2021-09-18 | 2024-06-18 | 江苏康宁杰瑞生物制药有限公司 | 包含pd-l1抗原结合片段的组合物及其用途 |
| WO2023057882A1 (en) | 2021-10-05 | 2023-04-13 | Pfizer Inc. | Combinations of azalactam compounds with a pd-1 axis binding antagonist for the treatment of cancer |
| WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
| TW202333785A (zh) * | 2021-11-16 | 2023-09-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | Ｃｌａｕｄｉｎ１８．２拮抗劑和ｐｄ－１／ｐｄ－ｌ１軸抑制劑的組合療法 |
| CN119213034A (zh) * | 2022-05-17 | 2024-12-27 | 苏州创胜医药集团有限公司 | 双功能蛋白质及其制剂和用途 |
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| CN120603849A (zh) * | 2023-01-18 | 2025-09-05 | 科望(苏州)生物医药科技有限公司 | 抗pdl1单域抗体、融合蛋白及其用途 |
| AR132623A1 (es) * | 2023-05-08 | 2025-07-16 | Hoffmann La Roche | PROTEÍNAS DE FUSIÓN DE INTERFERÓN a DIRIGIDAS Y MÉTODOS DE USO |
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- 2017-02-10 CA CA3007135A patent/CA3007135A1/en active Pending
- 2017-02-10 CN CN202010174431.5A patent/CN111363041B/zh active Active
- 2017-02-10 WO PCT/CN2017/073242 patent/WO2017161976A1/en not_active Ceased
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- 2017-02-10 JP JP2019500712A patent/JP7080213B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2744959C2 (ru) | 2021-03-17 |
| KR20180127971A (ko) | 2018-11-30 |
| WO2017161976A1 (en) | 2017-09-28 |
| JP2022068161A (ja) | 2022-05-09 |
| CN108779180B (zh) | 2020-10-16 |
| JP7080213B2 (ja) | 2022-06-03 |
| JP2023171733A (ja) | 2023-12-05 |
| CA3007135A1 (en) | 2017-09-28 |
| EP3433277A4 (en) | 2020-06-17 |
| JP7345578B2 (ja) | 2023-09-15 |
| US10822416B2 (en) | 2020-11-03 |
| US20190330348A1 (en) | 2019-10-31 |
| RU2018124602A (ru) | 2020-01-14 |
| RU2021106377A (ru) | 2021-03-31 |
| CN108779180A (zh) | 2018-11-09 |
| RU2018124602A3 (enExample) | 2020-03-06 |
| US20210009693A1 (en) | 2021-01-14 |
| RU2021106377A3 (enExample) | 2021-12-28 |
| JP7624484B2 (ja) | 2025-01-30 |
| EP3433277A1 (en) | 2019-01-30 |
| CN111363041A (zh) | 2020-07-03 |
| JP2019516394A (ja) | 2019-06-20 |
| US11753473B2 (en) | 2023-09-12 |
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