CN111295389A - 生物活性物偶联物及其制备方法和用途 - Google Patents

生物活性物偶联物及其制备方法和用途 Download PDF

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CN111295389A
CN111295389A CN201880069543.5A CN201880069543A CN111295389A CN 111295389 A CN111295389 A CN 111295389A CN 201880069543 A CN201880069543 A CN 201880069543A CN 111295389 A CN111295389 A CN 111295389A
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group
compound
antibody
conjugate
integer
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CN111295389B (zh
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蔡家强
宋帅
薛彤彤
肖亮
邓汉文
田强
汪静
刘登念
刘立平
喻海旻
杨周宁
曹旭
钟国庆
王利春
王晶翼
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Priority to CN202111114512.7A priority Critical patent/CN113683622A/zh
Priority to CN202111113700.8A priority patent/CN113698414B/zh
Priority to CN202111110433.9A priority patent/CN113651831A/zh
Priority to CN202111110831.0A priority patent/CN113603703A/zh
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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Abstract

本公开涉及生物活性物偶联物及其制备方法和用途，具体地，本公开涉及通过改进ADC或SMDC中药物与靶向部分的偶联方式获得的一类新颖的生物活性分子偶联物，及其制备方法和在制备治疗与细胞活动异常相关的疾病中的用途。

Description

PCT国内申请，说明书已公开。

Claims (91)

  1. PCT国内申请，权利要求书已公开。
CN201880069543.5A 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途 Active CN111295389B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202111114512.7A CN113683622A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111113700.8A CN113698414B (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111110433.9A CN113651831A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111110831.0A CN113603703A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途

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Application Number Priority Date Filing Date Title
CN201711347535 2017-12-15
CN2017113475356 2017-12-15
CN201810230346 2018-03-20
CN2018102303469 2018-03-20
CN201811071947 2018-09-14
CN2018110719476 2018-09-14
PCT/CN2018/120125 WO2019114666A1 (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途

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CN202111110433.9A Division CN113651831A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111110831.0A Division CN113603703A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111114512.7A Division CN113683622A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111113700.8A Division CN113698414B (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途

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CN111295389A true CN111295389A (zh) 2020-06-16
CN111295389B CN111295389B (zh) 2021-10-22

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CN202111114512.7A Pending CN113683622A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
CN202111110433.9A Pending CN113651831A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途
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CN202111110831.0A Pending CN113603703A (zh) 2017-12-15 2018-12-10 生物活性物偶联物及其制备方法和用途

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US (2) US11970506B2 (zh)
EP (1) EP3725798A4 (zh)
JP (2) JP7446993B2 (zh)
KR (1) KR20200099123A (zh)
CN (4) CN111295389B (zh)
CA (1) CA3080236A1 (zh)
WO (1) WO2019114666A1 (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
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CN113698414A (zh) * 2017-12-15 2021-11-26 四川科伦博泰生物医药股份有限公司 生物活性物偶联物及其制备方法和用途
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