CN110753697B - 磷酸酯衍生物的合成 - Google Patents

磷酸酯衍生物的合成 Download PDF

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Publication number
CN110753697B
CN110753697B CN201880039747.4A CN201880039747A CN110753697B CN 110753697 B CN110753697 B CN 110753697B CN 201880039747 A CN201880039747 A CN 201880039747A CN 110753697 B CN110753697 B CN 110753697B
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compound
mixture
formula iia
diastereomer
optionally substituted
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Chinese (zh)
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CN110753697A (zh
Inventor
休·格里菲斯
戈登·肯诺温
文卡塔·拉克希米·纳拉辛哈·拉奥·达马拉帕蒂
玛尼·布尚·科塔拉
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Nucana PLC
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Nucana Biomed Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201880039747.4A 2017-06-14 2018-06-14 磷酸酯衍生物的合成 Active CN110753697B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311430904.3A CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
GB1709471.5 2017-06-14
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311430904.3A Division CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成

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CN110753697A CN110753697A (zh) 2020-02-04
CN110753697B true CN110753697B (zh) 2023-10-13

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Application Number Title Priority Date Filing Date
CN201880039747.4A Active CN110753697B (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN202311430904.3A Pending CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039189.1A Active CN110785425B (zh) 2017-06-14 2018-06-14 3′-脱氧腺苷-5′-o-[苯基(苄氧基-l-丙氨酰基)]磷酸酯(nuc-7738)的合成

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202311430904.3A Pending CN117486959A (zh) 2017-06-14 2018-06-14 磷酸酯衍生物的合成
CN201880039189.1A Active CN110785425B (zh) 2017-06-14 2018-06-14 3′-脱氧腺苷-5′-o-[苯基(苄氧基-l-丙氨酰基)]磷酸酯(nuc-7738)的合成

Country Status (18)

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US (4) US11414452B2 (enExample)
EP (2) EP3638684A2 (enExample)
JP (4) JP7279991B2 (enExample)
KR (2) KR102695300B1 (enExample)
CN (3) CN110753697B (enExample)
AU (3) AU2018284131B2 (enExample)
BR (1) BR112019026747A2 (enExample)
CA (2) CA3064177A1 (enExample)
CL (1) CL2019003632A1 (enExample)
EA (1) EA201992873A1 (enExample)
GB (1) GB201709471D0 (enExample)
IL (3) IL312228B2 (enExample)
MA (1) MA49379A (enExample)
MX (3) MX390901B (enExample)
PH (1) PH12019502825A1 (enExample)
SA (1) SA519410795B1 (enExample)
SG (1) SG11201911543UA (enExample)
WO (2) WO2018229493A2 (enExample)

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CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
CN119546313A (zh) 2022-05-12 2025-02-28 努卡那有限公司 使用nuc-7738的癌症治疗
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KR20200016864A (ko) 2020-02-17
CL2019003632A1 (es) 2020-08-14
CA3065682A1 (en) 2018-12-20
MA49379A (fr) 2020-04-22
EA201992873A1 (ru) 2020-05-19
US20220402962A1 (en) 2022-12-22
AU2018284131B2 (en) 2022-04-07
JP2023095954A (ja) 2023-07-06
GB201709471D0 (en) 2017-07-26
CA3064177A1 (en) 2018-12-20
AU2022204691B2 (en) 2023-11-23
BR112019026747A2 (pt) 2020-06-30
WO2018229493A2 (en) 2018-12-20
PH12019502825A1 (en) 2020-10-26
IL302559B1 (en) 2024-05-01
MX2022003822A (es) 2022-05-25
IL271159B1 (en) 2023-06-01
AU2022204691A1 (en) 2022-08-04
AU2024200428A1 (en) 2024-02-08
US11414452B2 (en) 2022-08-16
IL302559A (en) 2023-07-01
IL302559B2 (en) 2024-09-01
MX2019014914A (es) 2020-02-13
JP2024138523A (ja) 2024-10-08
JP2020523381A (ja) 2020-08-06
JP7525687B2 (ja) 2024-07-30
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
KR20240127483A (ko) 2024-08-22
MX390901B (es) 2025-03-21
US20200181190A1 (en) 2020-06-11
WO2018229495A1 (en) 2018-12-20
IL312228B2 (en) 2025-06-01
CN110753697A (zh) 2020-02-04
JP7279991B2 (ja) 2023-05-23
SA519410795B1 (ar) 2023-11-19
JP7248209B2 (ja) 2023-03-29
CN110785425B (zh) 2023-11-21
IL271159B2 (en) 2023-10-01
AU2024200428B2 (en) 2025-10-16
SG11201911543UA (en) 2020-01-30
US20200181186A1 (en) 2020-06-11
EP3638685A1 (en) 2020-04-22
MX391332B (es) 2025-03-21
US11897913B2 (en) 2024-02-13
CN110785425A (zh) 2020-02-11
KR102695300B1 (ko) 2024-08-16
US20250171487A1 (en) 2025-05-29
CN117486959A (zh) 2024-02-02
AU2018284131A1 (en) 2020-01-16
MX2019014907A (es) 2020-02-13
EP3638684A2 (en) 2020-04-22
US12054511B2 (en) 2024-08-06
WO2018229493A3 (en) 2019-02-07
IL312228A (en) 2024-06-01
JP2020523378A (ja) 2020-08-06

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