AU2018284131B2 - Synthesis of substantially diastereomerically pure phosphate protides - Google Patents

Synthesis of substantially diastereomerically pure phosphate protides Download PDF

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Publication number
AU2018284131B2
AU2018284131B2 AU2018284131A AU2018284131A AU2018284131B2 AU 2018284131 B2 AU2018284131 B2 AU 2018284131B2 AU 2018284131 A AU2018284131 A AU 2018284131A AU 2018284131 A AU2018284131 A AU 2018284131A AU 2018284131 B2 AU2018284131 B2 AU 2018284131B2
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compound
diastereoisomer
formula
mixture
formula ila
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AU2018284131A1 (en
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Venkata Lakshmi Narasimha Rao Dammalapati
Hugh GRIFFITH
Gordon KENNOVIN
Mani Bushan KOTALA
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Nucana PLC
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Nucana PLC
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Priority to AU2022204691A priority Critical patent/AU2022204691B2/en
Priority to AU2024200428A priority patent/AU2024200428C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2018284131A 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides Active AU2018284131B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022204691A AU2022204691B2 (en) 2017-06-14 2022-06-30 Synthesis of substantially diastereomerically pure phosphate protides
AU2024200428A AU2024200428C1 (en) 2017-06-14 2024-01-24 Synthesis of substantially diastereomerically pure phosphate protides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1709471.5 2017-06-14
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives

Related Child Applications (1)

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AU2022204691A Division AU2022204691B2 (en) 2017-06-14 2022-06-30 Synthesis of substantially diastereomerically pure phosphate protides

Publications (2)

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AU2018284131A1 AU2018284131A1 (en) 2020-01-16
AU2018284131B2 true AU2018284131B2 (en) 2022-04-07

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AU2018284131A Active AU2018284131B2 (en) 2017-06-14 2018-06-14 Synthesis of substantially diastereomerically pure phosphate protides
AU2022204691A Active AU2022204691B2 (en) 2017-06-14 2022-06-30 Synthesis of substantially diastereomerically pure phosphate protides
AU2024200428A Active AU2024200428C1 (en) 2017-06-14 2024-01-24 Synthesis of substantially diastereomerically pure phosphate protides

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AU2024200428A Active AU2024200428C1 (en) 2017-06-14 2024-01-24 Synthesis of substantially diastereomerically pure phosphate protides

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US (4) US11897913B2 (enExample)
EP (3) EP3638684B1 (enExample)
JP (5) JP7248209B2 (enExample)
KR (2) KR102695300B1 (enExample)
CN (3) CN117486959A (enExample)
AU (3) AU2018284131B2 (enExample)
BR (1) BR112019026747A2 (enExample)
CA (2) CA3065682A1 (enExample)
CL (1) CL2019003632A1 (enExample)
EA (1) EA201992873A1 (enExample)
ES (1) ES3075652T3 (enExample)
GB (1) GB201709471D0 (enExample)
IL (3) IL302559B2 (enExample)
MA (1) MA49379A (enExample)
MX (3) MX390901B (enExample)
NZ (2) NZ759692A (enExample)
PH (1) PH12019502825A1 (enExample)
SA (1) SA519410795B1 (enExample)
SG (1) SG11201911543UA (enExample)
WO (2) WO2018229493A2 (enExample)
ZA (1) ZA201908054B (enExample)

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CA3007347C (en) 2015-12-11 2020-08-04 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
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GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
KR20250012582A (ko) 2022-05-12 2025-01-24 뉴카나 피엘씨 암 치료
CN120584123A (zh) 2022-12-07 2025-09-02 努卡那有限公司 核苷衍生物nuc-3373的合成

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IL271159B2 (en) 2023-10-01
US20200181186A1 (en) 2020-06-11
SG11201911543UA (en) 2020-01-30
US11414452B2 (en) 2022-08-16
MX391332B (es) 2025-03-21
IL302559B2 (en) 2024-09-01
WO2018229495A1 (en) 2018-12-20
AU2022204691A1 (en) 2022-08-04
JP7279991B2 (ja) 2023-05-23
JP2020523381A (ja) 2020-08-06
IL312228B2 (en) 2025-06-01
US20220402962A1 (en) 2022-12-22
CN110753697A (zh) 2020-02-04
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
EP3638684C0 (en) 2026-07-08
NZ800534A (en) 2026-03-27
AU2018284131A1 (en) 2020-01-16
EP3638684B1 (en) 2026-07-08
CN110753697B (zh) 2023-10-13
JP7525687B2 (ja) 2024-07-30
ZA201908054B (en) 2026-05-27
GB201709471D0 (en) 2017-07-26
JP2026034703A (ja) 2026-02-27
MX390901B (es) 2025-03-21
CN110785425A (zh) 2020-02-11
AU2024200428C1 (en) 2026-04-30
MX2019014914A (es) 2020-02-13
JP2024138523A (ja) 2024-10-08
CN117486959A (zh) 2024-02-02
US12054511B2 (en) 2024-08-06
PH12019502825A1 (en) 2020-10-26
WO2018229493A3 (en) 2019-02-07
US20250171487A1 (en) 2025-05-29
EP3638685A1 (en) 2020-04-22
JP2023095954A (ja) 2023-07-06
MX2022003822A (es) 2022-05-25
EA201992873A1 (ru) 2020-05-19
MX2019014907A (es) 2020-02-13
KR102920287B1 (ko) 2026-01-30
AU2022204691B2 (en) 2023-11-23
SA519410795B1 (ar) 2023-11-19
KR102695300B1 (ko) 2024-08-16
KR20200016864A (ko) 2020-02-17
IL312228A (en) 2024-06-01
AU2024200428A1 (en) 2024-02-08
WO2018229493A2 (en) 2018-12-20
CA3064177A1 (en) 2018-12-20
JP7248209B2 (ja) 2023-03-29
MA49379A (fr) 2020-04-22
NZ759692A (en) 2026-03-27
EP4786476A2 (en) 2026-08-05
US20200181190A1 (en) 2020-06-11
EP3638684A2 (en) 2020-04-22
CL2019003632A1 (es) 2020-08-14
AU2024200428B2 (en) 2025-10-16
IL302559B1 (en) 2024-05-01
ES3075652T3 (en) 2026-08-06
JP2020523378A (ja) 2020-08-06
KR20240127483A (ko) 2024-08-22
IL271159B1 (en) 2023-06-01
CN110785425B (zh) 2023-11-21
BR112019026747A2 (pt) 2020-06-30
CA3065682A1 (en) 2018-12-20
US11897913B2 (en) 2024-02-13
IL302559A (en) 2023-07-01

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