CN110461356A - 用于调节肺中炎性体活性和炎症的方法 - Google Patents

用于调节肺中炎性体活性和炎症的方法 Download PDF

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Publication number
CN110461356A
CN110461356A CN201780087090.4A CN201780087090A CN110461356A CN 110461356 A CN110461356 A CN 110461356A CN 201780087090 A CN201780087090 A CN 201780087090A CN 110461356 A CN110461356 A CN 110461356A
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antibody
asc
inflammasome
lung
caspase
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R·基恩
D·迪特里希
N·克尔
S·吴
J·P·德里韦罗·瓦卡里
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University of Miami
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University of Miami
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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CN201780087090.4A 2016-12-29 2017-12-28 用于调节肺中炎性体活性和炎症的方法 Pending CN110461356A (zh)

Applications Claiming Priority (3)

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US201662440180P 2016-12-29 2016-12-29
US62/440,180 2016-12-29
PCT/US2017/068713 WO2018126009A1 (en) 2016-12-29 2017-12-28 Method for modulating inflammasome activity and inflammation in the lung

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US (5) US20190336598A1 (enExample)
EP (2) EP3562506A4 (enExample)
JP (3) JP2020503345A (enExample)
KR (1) KR20200013630A (enExample)
CN (1) CN110461356A (enExample)
AU (1) AU2017386550A1 (enExample)
BR (1) BR112019013463A2 (enExample)
CA (2) CA3048864A1 (enExample)
CO (1) CO2019008087A2 (enExample)
IL (1) IL267685A (enExample)
MX (1) MX2019007916A (enExample)
PH (1) PH12019501549A1 (enExample)
RU (1) RU2019123160A (enExample)
SG (1) SG10202106385XA (enExample)
WO (2) WO2018126009A1 (enExample)
ZA (1) ZA201904861B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111529707A (zh) * 2020-04-29 2020-08-14 威海市立医院 Gsdmd抑制剂在制备治疗幽门螺杆菌感染的药物中的应用
CN113109569A (zh) * 2021-03-05 2021-07-13 李朴 Gsdmd作为生物标志物在胸腔积液相关疾病鉴别诊断及疗效评估上的用途
CN115551512A (zh) * 2020-03-19 2022-12-30 南洋理工大学 包含nlrp1炎性体激活抑制剂的化合物或组合物用于治疗人气道炎症的用途

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021222263A2 (en) * 2020-04-27 2021-11-04 University Of Miami Compositions and methods for treating inflammasome related diseases or conditions
US11840565B2 (en) 2016-12-29 2023-12-12 University Of Miami Methods and compositions for treating virus-associated inflammation
WO2018126009A1 (en) 2016-12-29 2018-07-05 University Of Miami Method for modulating inflammasome activity and inflammation in the lung
SG11202013176VA (en) * 2018-07-03 2021-01-28 Univ Miami Compositions and methods for treating inflammasome related diseases or conditions
EP3938781B1 (en) * 2019-03-13 2025-12-10 Fundación para la Formación e Investigación Sanitarias de la Región De Murcia (FFIS) In vitro
WO2021097084A1 (en) * 2019-11-12 2021-05-20 The Uab Research Foundation Methods for treating immunosuppression and diseases associated with immunosuppression
CN111363847B (zh) * 2020-02-12 2021-06-29 广州微远医疗器械有限公司 基于CRISPR技术的2019-nCoV快速检测引物组及其用途
CN113278730B (zh) * 2020-02-20 2022-03-25 中元汇吉生物技术股份有限公司 一种新型冠状病毒检测试剂盒、用途及其使用方法
CN111289745A (zh) * 2020-03-25 2020-06-16 中山生物工程有限公司 新型冠状病毒IgM抗体酶联免疫检测试剂盒及其检测方法
KR102658146B1 (ko) * 2020-03-26 2024-04-18 경북대학교 산학협력단 Pannexin3을 포함하는 근육 손상 진단용 바이오마커 조성물 및 이를 이용한 진단방법
CN111777684A (zh) * 2020-06-09 2020-10-16 重庆君同生物技术有限公司 冠状病毒串联表位蛋白所诱导抗体的制备方法及其应用
IL299793A (en) * 2020-07-09 2023-03-01 Remedy Cell Ltd Methods for treating acute respiratory distress syndrome and cytokine storm
KR102582417B1 (ko) * 2020-11-06 2023-09-26 한국과학기술원 인플라마솜 어댑터 단백질(asc)의 중합체화 도메인에 결합하는 신규한 폴리펩타이드 및 이의 용도
AU2022211971A1 (en) 2021-01-29 2023-08-10 Illimis Therapeutics, Inc. Fusion molecule having non-inflammatory phagocytosis inducing activity
KR102673132B1 (ko) * 2021-04-20 2024-06-12 아주대학교산학협력단 염증성 질환 치료를 위한 nlrp3 인플라마좀 억제 펩타이드
EP4337676A1 (en) 2021-05-10 2024-03-20 Entrada Therapeutics, Inc. Antigen-binding and antigen degradation constructs
CN118119644A (zh) * 2021-08-25 2024-05-31 R.P.谢勒技术有限责任公司 具有人源化框架区的抗体
CN115819548B (zh) * 2021-11-16 2023-09-01 北京美德泰康生物科技有限公司 一种检测炎症相关疾病的标志物和方法
WO2024006457A1 (en) * 2022-06-29 2024-01-04 University Of South Florida Method of treating long-covid induced neurologic diseases
WO2024114906A1 (en) 2022-11-30 2024-06-06 Mabylon Ag Antibodies against apoptosis-associated speck-like protein containing a card (asc) and uses thereof
WO2024248287A1 (ko) * 2023-06-01 2024-12-05 한양대학교 에리카산학협력단 결핵균 유래 폴리펩타이드를 포함하는 염증성 질환 치료용 약학 조성물
WO2025081130A1 (en) * 2023-10-12 2025-04-17 University Of Miami Use of anti-asc antibody in the treating of ocular disorders

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009014863A2 (en) * 2007-06-29 2009-01-29 Thomas Jefferson University Asc and pyrin-asc pyroptosomes and uses thereof
US20100150938A1 (en) * 2008-07-03 2010-06-17 University Of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
CN102596227A (zh) * 2009-09-11 2012-07-18 普罗塔芬生物技术股份公司 用于治疗cxcl8介导的肺部炎症的组合物
US20140314746A1 (en) * 2013-03-13 2014-10-23 Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine Methods for treating or preventing fibrosis in subjects afflicted with scleroderma
WO2015016178A1 (ja) * 2013-07-29 2015-02-05 国立大学法人鹿児島大学 １，５－ｄ－アンヒドロフルクトースを含むアポトーシス関連スペック様カード蛋白質の機能阻害薬

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018194A1 (en) 2000-11-28 2004-01-29 Francisco Joseph A. Recombinant anti-CD30 antibodies and uses thereof
CA2565063A1 (en) 2004-04-29 2005-11-24 Otsuka Pharmaceutical Co., Ltd. Glycoprotein vi antibodies and method thereof
US7780963B2 (en) 2004-10-25 2010-08-24 Merck & Co., Inc. Anti-ADDL antibodies and uses thereof
TW200636064A (en) 2004-10-28 2006-10-16 Centocor Inc Anti-respiratory syncytial virus antibodies, antigens and uses thereof
CA2679399A1 (en) 2007-02-27 2008-09-04 Genetech, Inc. Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
SMT202000095T1 (it) 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
IT1406201B1 (it) 2010-12-10 2014-02-14 Univ Degli Studi Trieste Biomarcatori per la diagnosi della sclerosi multipla
CA2826820A1 (en) 2011-03-11 2012-09-20 F. Hoffmann-La Roche Ag Asc as marker for chronic obstructive pulmonary disease (copd)
WO2013119673A1 (en) 2012-02-06 2013-08-15 University Of Miami Innate immune proteins as biomarkers for cns injury
TWI480044B (zh) 2012-03-16 2015-04-11 Taichung Veterans General Hospital A high molecular weight heparin or low molecular weight heparin for the preparation of a composition for at least two consecutive days of administration to improve the allergic constitution
KR20160005044A (ko) * 2013-05-17 2016-01-13 제넨테크, 인크. 염증성 장 질환의 진단 및 치료 방법
NZ722927A (en) * 2014-01-10 2022-07-29 Avalyn Pharma Inc Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10143709B2 (en) * 2014-05-06 2018-12-04 Indiana University Research And Technology Corporation Use of ASC and ASC-CM to treat ARDS, SARS, and MERS
WO2016028699A2 (en) 2014-08-18 2016-02-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biomarkers for diagnosis and management of neuro-immunological diseases
US20160263183A1 (en) 2015-03-10 2016-09-15 Brown University Methods for treating lung disease
EP3294752B1 (en) * 2015-05-12 2020-11-04 The Regents of the University of California Peptide treatment for inflammation and fibrosis
TWI743047B (zh) 2015-08-17 2021-10-21 安成生物科技股份有限公司 使用雙醋瑞因或其類似物抑制asc表現、nlrp3表現、以及/或nlrp3發炎體複合物的形成之方法
KR101948048B1 (ko) 2016-12-08 2019-02-14 한양대학교 에리카산학협력단 톡소포자충 ｇｒａ７ 항원 유래 재조합 단백질을 유효성분으로 포함하는 결핵 예방 또는 치료용 약학 조성물
WO2018126009A1 (en) 2016-12-29 2018-07-05 University Of Miami Method for modulating inflammasome activity and inflammation in the lung
KR20200088299A (ko) 2017-09-20 2020-07-22 더 유니버시티 오브 마이애미 신경학적 장애의 바이오마커로서 인플라마솜 단백질의 검출 방법
SG11202013176VA (en) 2018-07-03 2021-01-28 Univ Miami Compositions and methods for treating inflammasome related diseases or conditions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009014863A2 (en) * 2007-06-29 2009-01-29 Thomas Jefferson University Asc and pyrin-asc pyroptosomes and uses thereof
US20100150938A1 (en) * 2008-07-03 2010-06-17 University Of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
CN102596227A (zh) * 2009-09-11 2012-07-18 普罗塔芬生物技术股份公司 用于治疗cxcl8介导的肺部炎症的组合物
US20140314746A1 (en) * 2013-03-13 2014-10-23 Philadelphia Health And Education Corporation, d/b/a Drexel University College of Medicine Methods for treating or preventing fibrosis in subjects afflicted with scleroderma
WO2015016178A1 (ja) * 2013-07-29 2015-02-05 国立大学法人鹿児島大学 １，５－ｄ－アンヒドロフルクトースを含むアポトーシス関連スペック様カード蛋白質の機能阻害薬

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115551512A (zh) * 2020-03-19 2022-12-30 南洋理工大学 包含nlrp1炎性体激活抑制剂的化合物或组合物用于治疗人气道炎症的用途
CN111529707A (zh) * 2020-04-29 2020-08-14 威海市立医院 Gsdmd抑制剂在制备治疗幽门螺杆菌感染的药物中的应用
CN111529707B (zh) * 2020-04-29 2021-04-23 威海市立医院 Gsdmd抑制剂在制备治疗幽门螺杆菌感染的药物中的应用
CN113109569A (zh) * 2021-03-05 2021-07-13 李朴 Gsdmd作为生物标志物在胸腔积液相关疾病鉴别诊断及疗效评估上的用途
CN113109569B (zh) * 2021-03-05 2022-08-19 李朴 Gsdmd作为生物标志物在胸腔积液相关疾病鉴别诊断及疗效评估上的用途

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