RU2019123160A - Способ модуляции активности инфламмасом и воспаления в легком - Google Patents
Способ модуляции активности инфламмасом и воспаления в легком Download PDFInfo
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- RU2019123160A RU2019123160A RU2019123160A RU2019123160A RU2019123160A RU 2019123160 A RU2019123160 A RU 2019123160A RU 2019123160 A RU2019123160 A RU 2019123160A RU 2019123160 A RU2019123160 A RU 2019123160A RU 2019123160 A RU2019123160 A RU 2019123160A
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- Prior art keywords
- antibody
- inflammasome
- patient
- binds
- protein
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- 238000000034 method Methods 0.000 title claims 43
- 210000004072 lung Anatomy 0.000 title claims 7
- 206010061218 Inflammation Diseases 0.000 title claims 5
- 230000004054 inflammatory process Effects 0.000 title claims 5
- 230000000694 effects Effects 0.000 title claims 3
- 108010034143 Inflammasomes Proteins 0.000 claims 16
- 102100029647 Apoptosis-associated speck-like protein containing a CARD Human genes 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 6
- 206010069351 acute lung injury Diseases 0.000 claims 6
- 210000003169 central nervous system Anatomy 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 210000005265 lung cell Anatomy 0.000 claims 6
- 102000002164 CARD domains Human genes 0.000 claims 4
- 108050009503 CARD domains Proteins 0.000 claims 4
- 102100035904 Caspase-1 Human genes 0.000 claims 4
- 108090000426 Caspase-1 Proteins 0.000 claims 4
- 101001109463 Homo sapiens NACHT, LRR and PYD domains-containing protein 1 Proteins 0.000 claims 4
- 101001128138 Homo sapiens NACHT, LRR and PYD domains-containing protein 2 Proteins 0.000 claims 4
- 101000979572 Homo sapiens NLR family CARD domain-containing protein 4 Proteins 0.000 claims 4
- 102000003810 Interleukin-18 Human genes 0.000 claims 4
- 108090000171 Interleukin-18 Proteins 0.000 claims 4
- 102100022698 NACHT, LRR and PYD domains-containing protein 1 Human genes 0.000 claims 4
- 102100031897 NACHT, LRR and PYD domains-containing protein 2 Human genes 0.000 claims 4
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 4
- 102100023435 NLR family CARD domain-containing protein 4 Human genes 0.000 claims 4
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 229960002897 heparin Drugs 0.000 claims 4
- 229920000669 heparin Polymers 0.000 claims 4
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 claims 4
- 208000020431 spinal cord injury Diseases 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 108010076667 Caspases Proteins 0.000 claims 3
- 102000011727 Caspases Human genes 0.000 claims 3
- 101710136259 E3 ubiquitin-protein ligase XIAP Proteins 0.000 claims 3
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 102000050257 X-Linked Inhibitor of Apoptosis Human genes 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 210000004901 leucine-rich repeat Anatomy 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 230000007115 recruitment Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 2
- 102000055207 HMGB1 Human genes 0.000 claims 2
- 108700010013 HMGB1 Proteins 0.000 claims 2
- 101150021904 HMGB1 gene Proteins 0.000 claims 2
- 101000933115 Mus musculus Caspase-4 Proteins 0.000 claims 2
- 102100032361 Pannexin-1 Human genes 0.000 claims 2
- 101710165201 Pannexin-1 Proteins 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960000610 enoxaparin Drugs 0.000 claims 2
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 230000008719 thickening Effects 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 102000012064 NLR Proteins Human genes 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
Classifications
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
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- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662440180P | 2016-12-29 | 2016-12-29 | |
| US62/440,180 | 2016-12-29 | ||
| PCT/US2017/068713 WO2018126009A1 (en) | 2016-12-29 | 2017-12-28 | Method for modulating inflammasome activity and inflammation in the lung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019123160A3 RU2019123160A3 (enExample) | 2021-01-29 |
| RU2019123160A true RU2019123160A (ru) | 2021-01-29 |
Family
ID=62710025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019123160A RU2019123160A (ru) | 2016-12-29 | 2017-12-28 | Способ модуляции активности инфламмасом и воспаления в легком |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20190336598A1 (enExample) |
| EP (2) | EP3562506A4 (enExample) |
| JP (3) | JP2020503345A (enExample) |
| KR (1) | KR20200013630A (enExample) |
| CN (1) | CN110461356A (enExample) |
| AU (1) | AU2017386550A1 (enExample) |
| BR (1) | BR112019013463A2 (enExample) |
| CA (2) | CA3048864A1 (enExample) |
| CO (1) | CO2019008087A2 (enExample) |
| IL (1) | IL267685A (enExample) |
| MX (1) | MX2019007916A (enExample) |
| PH (1) | PH12019501549A1 (enExample) |
| RU (1) | RU2019123160A (enExample) |
| SG (1) | SG10202106385XA (enExample) |
| WO (2) | WO2018126009A1 (enExample) |
| ZA (1) | ZA201904861B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| SG10202106385XA (en) | 2016-12-29 | 2021-07-29 | Univ Miami | Method for modulating inflammasome activity and inflammation in the lung |
| CA3105129A1 (en) * | 2018-07-03 | 2020-01-09 | University Of Miami | Compositions and methods for treating inflammasome related diseases or conditions |
| US20220334127A1 (en) * | 2019-03-13 | 2022-10-20 | Fundación Para La Formación E Investigación Sanitarias De La Región De Murcia (Ffis) | In vitro method for obtaining clinical data in patients suffering from an inflammatory disease |
| WO2021097084A1 (en) * | 2019-11-12 | 2021-05-20 | The Uab Research Foundation | Methods for treating immunosuppression and diseases associated with immunosuppression |
| CN111363847B (zh) * | 2020-02-12 | 2021-06-29 | 广州微远医疗器械有限公司 | 基于CRISPR技术的2019-nCoV快速检测引物组及其用途 |
| CN113278730B (zh) * | 2020-02-20 | 2022-03-25 | 中元汇吉生物技术股份有限公司 | 一种新型冠状病毒检测试剂盒、用途及其使用方法 |
| WO2021188052A1 (en) * | 2020-03-19 | 2021-09-23 | Nanyang Technological University | Use of a compound or composition comprising an inhibitor of nlrp1 inflammasome activation for the treatment of human airway inflammation |
| CN111289745A (zh) * | 2020-03-25 | 2020-06-16 | 中山生物工程有限公司 | 新型冠状病毒IgM抗体酶联免疫检测试剂盒及其检测方法 |
| KR102658146B1 (ko) * | 2020-03-26 | 2024-04-18 | 경북대학교 산학협력단 | Pannexin3을 포함하는 근육 손상 진단용 바이오마커 조성물 및 이를 이용한 진단방법 |
| CA3176521A1 (en) * | 2020-04-27 | 2021-11-04 | University Of Miami | Compositions and methods for treating inflammasome related diseases or conditions |
| CN111529707B (zh) * | 2020-04-29 | 2021-04-23 | 威海市立医院 | Gsdmd抑制剂在制备治疗幽门螺杆菌感染的药物中的应用 |
| CN111777684A (zh) * | 2020-06-09 | 2020-10-16 | 重庆君同生物技术有限公司 | 冠状病毒串联表位蛋白所诱导抗体的制备方法及其应用 |
| IL299793A (en) * | 2020-07-09 | 2023-03-01 | Remedy Cell Ltd | Methods for treating acute respiratory distress syndrome and cytokine storm |
| KR102582417B1 (ko) * | 2020-11-06 | 2023-09-26 | 한국과학기술원 | 인플라마솜 어댑터 단백질(asc)의 중합체화 도메인에 결합하는 신규한 폴리펩타이드 및 이의 용도 |
| MX2023008744A (es) | 2021-01-29 | 2023-10-02 | Illimis Therapeutics Inc | Molecula de fusion que tiene actividad no inflamatoria inductora de la fagocitosis. |
| CN113109569B (zh) * | 2021-03-05 | 2022-08-19 | 李朴 | Gsdmd作为生物标志物在胸腔积液相关疾病鉴别诊断及疗效评估上的用途 |
| KR102673132B1 (ko) * | 2021-04-20 | 2024-06-12 | 아주대학교산학협력단 | 염증성 질환 치료를 위한 nlrp3 인플라마좀 억제 펩타이드 |
| EP4337676A1 (en) | 2021-05-10 | 2024-03-20 | Entrada Therapeutics, Inc. | Antigen-binding and antigen degradation constructs |
| WO2023028537A2 (en) * | 2021-08-25 | 2023-03-02 | R.P. Scherer Technologies, Llc | Antibodies having humanized framework regions |
| CN115819548B (zh) * | 2021-11-16 | 2023-09-01 | 北京美德泰康生物科技有限公司 | 一种检测炎症相关疾病的标志物和方法 |
| WO2024006457A1 (en) * | 2022-06-29 | 2024-01-04 | University Of South Florida | Method of treating long-covid induced neurologic diseases |
| WO2024114906A1 (en) | 2022-11-30 | 2024-06-06 | Mabylon Ag | Antibodies against apoptosis-associated speck-like protein containing a card (asc) and uses thereof |
| WO2024248287A1 (ko) * | 2023-06-01 | 2024-12-05 | 한양대학교 에리카산학협력단 | 결핵균 유래 폴리펩타이드를 포함하는 염증성 질환 치료용 약학 조성물 |
| WO2025081130A1 (en) * | 2023-10-12 | 2025-04-17 | University Of Miami | Use of anti-asc antibody in the treating of ocular disorders |
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|---|---|---|---|---|
| US20040018194A1 (en) | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
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2018
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| AU2017386550A1 (en) | 2019-08-08 |
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| CA3048864A1 (en) | 2018-07-05 |
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| BR112019013463A2 (pt) | 2020-01-07 |
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| KR20200013630A (ko) | 2020-02-07 |
| JP2020503345A (ja) | 2020-01-30 |
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| US10703811B2 (en) | 2020-07-07 |
| ZA201904861B (en) | 2024-11-27 |
| MX2019007916A (es) | 2019-12-05 |
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