CN110431134A - 作为变构shp2抑制剂的吡啶化合物 - Google Patents
作为变构shp2抑制剂的吡啶化合物 Download PDFInfo
- Publication number
- CN110431134A CN110431134A CN201880019182.3A CN201880019182A CN110431134A CN 110431134 A CN110431134 A CN 110431134A CN 201880019182 A CN201880019182 A CN 201880019182A CN 110431134 A CN110431134 A CN 110431134A
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- Prior art keywords
- alkyl
- compound
- heterocycle
- formula
- optionally substituted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449529P | 2017-01-23 | 2017-01-23 | |
| US62/449,529 | 2017-01-23 | ||
| PCT/US2018/013018 WO2018136264A1 (en) | 2017-01-23 | 2018-01-09 | Pyridine compounds as allosteric shp2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110431134A true CN110431134A (zh) | 2019-11-08 |
Family
ID=61054565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880019182.3A Pending CN110431134A (zh) | 2017-01-23 | 2018-01-09 | 作为变构shp2抑制剂的吡啶化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11673896B2 (https=) |
| EP (2) | EP3571189B1 (https=) |
| JP (2) | JP7240320B2 (https=) |
| KR (1) | KR20190110588A (https=) |
| CN (1) | CN110431134A (https=) |
| AU (1) | AU2018210196B2 (https=) |
| BR (1) | BR112019014527A2 (https=) |
| CA (1) | CA3051054A1 (https=) |
| IL (1) | IL268031B (https=) |
| MX (1) | MX2019008696A (https=) |
| RU (1) | RU2019126455A (https=) |
| SG (1) | SG11201906412SA (https=) |
| WO (1) | WO2018136264A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111138412A (zh) * | 2018-11-06 | 2020-05-12 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
| WO2022007869A1 (zh) * | 2020-07-10 | 2022-01-13 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
| CN114761394A (zh) * | 2020-01-16 | 2022-07-15 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
Families Citing this family (100)
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| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| WO2017210134A1 (en) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Heterocyclic inhibitors of ptpn11 |
| WO2017216706A1 (en) | 2016-06-14 | 2017-12-21 | Novartis Ag | Compounds and compositions for inhibiting the activity of shp2 |
| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| WO2018057884A1 (en) | 2016-09-22 | 2018-03-29 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
| TW202500565A (zh) | 2016-10-24 | 2025-01-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| EP3630770B1 (en) | 2017-05-26 | 2024-08-28 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors |
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| EP3687997A1 (en) | 2017-09-29 | 2020-08-05 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
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- 2018-01-09 SG SG11201906412SA patent/SG11201906412SA/en unknown
- 2018-01-09 EP EP18701882.5A patent/EP3571189B1/en active Active
- 2018-01-09 CN CN201880019182.3A patent/CN110431134A/zh active Pending
- 2018-01-09 BR BR112019014527-3A patent/BR112019014527A2/pt not_active Application Discontinuation
- 2018-01-09 CA CA3051054A patent/CA3051054A1/en not_active Abandoned
- 2018-01-09 WO PCT/US2018/013018 patent/WO2018136264A1/en not_active Ceased
- 2018-01-09 JP JP2019539779A patent/JP7240320B2/ja active Active
- 2018-01-09 EP EP23163674.7A patent/EP4230623A3/en not_active Withdrawn
- 2018-01-09 RU RU2019126455A patent/RU2019126455A/ru unknown
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2019
- 2019-07-14 IL IL268031A patent/IL268031B/en unknown
- 2019-07-22 US US16/518,796 patent/US11673896B2/en active Active
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2022
- 2022-11-25 JP JP2022187880A patent/JP2023018094A/ja active Pending
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2023
- 2023-04-25 US US18/138,917 patent/US20240092795A1/en not_active Abandoned
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111138412A (zh) * | 2018-11-06 | 2020-05-12 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
| CN111138412B (zh) * | 2018-11-06 | 2023-09-15 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
| CN114761394A (zh) * | 2020-01-16 | 2022-07-15 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
| CN114761394B (zh) * | 2020-01-16 | 2024-03-29 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
| WO2022007869A1 (zh) * | 2020-07-10 | 2022-01-13 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
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| MX2019008696A (es) | 2019-09-13 |
| EP4230623A2 (en) | 2023-08-23 |
| WO2018136264A1 (en) | 2018-07-26 |
| JP2023018094A (ja) | 2023-02-07 |
| CA3051054A1 (en) | 2018-07-26 |
| IL268031A (en) | 2019-09-26 |
| US20240092795A1 (en) | 2024-03-21 |
| SG11201906412SA (en) | 2019-08-27 |
| JP2020505376A (ja) | 2020-02-20 |
| AU2018210196A1 (en) | 2019-08-15 |
| IL268031B (en) | 2022-06-01 |
| AU2018210196B2 (en) | 2022-06-02 |
| EP4230623A3 (en) | 2023-10-11 |
| US11673896B2 (en) | 2023-06-13 |
| RU2019126455A (ru) | 2021-02-24 |
| BR112019014527A2 (pt) | 2020-02-27 |
| WO2018136264A9 (en) | 2018-10-25 |
| EP3571189B1 (en) | 2023-03-29 |
| KR20190110588A (ko) | 2019-09-30 |
| JP7240320B2 (ja) | 2023-03-15 |
| RU2019126455A3 (https=) | 2021-05-17 |
| EP3571189A1 (en) | 2019-11-27 |
| US20200017517A1 (en) | 2020-01-16 |
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