CN110226948A - 用于鉴定生物组织的系统和方法 - Google Patents
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Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU226837B1 (hu) | 2006-05-31 | 2009-12-28 | Semmelweis Egyetem | Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz |
| EP2435814B1 (en) | 2009-05-27 | 2017-09-27 | Micromass UK Limited | System and method for identification of biological tissues |
| DE102010015899B4 (de) * | 2010-02-04 | 2022-07-28 | Erbe Elektromedizin Gmbh | Elektrochirurgische Anordnung und elektrochirurgisches Instrument |
| GB201109414D0 (en) | 2011-06-03 | 2011-07-20 | Micromass Ltd | Diathermy -ionisation technique |
| CN108511315B (zh) * | 2011-12-28 | 2021-01-08 | 英国质谱有限公司 | 碰撞离子发生器和分离器 |
| EP2798344B1 (en) | 2011-12-28 | 2023-12-13 | Micromass UK Limited | System and method for rapid evaporative ionization of liquid phase samples |
| WO2014142925A1 (en) * | 2013-03-14 | 2014-09-18 | Empire Technology Development Llc | Identification of surgical smoke |
| US9255907B2 (en) | 2013-03-14 | 2016-02-09 | Empire Technology Development Llc | Identification of surgical smoke |
| WO2014142927A1 (en) * | 2013-03-14 | 2014-09-18 | Empire Technology Development Llc | Identification of surgical smoke |
| JP6061297B2 (ja) * | 2013-05-23 | 2017-01-18 | 国立大学法人浜松医科大学 | 試料分析装置 |
| CN104576287B (zh) * | 2013-10-16 | 2017-05-03 | 北京理工大学 | 一种大气压接口的离子源系统以及质谱仪 |
| US20160341712A1 (en) * | 2013-10-23 | 2016-11-24 | Brigham And Women's Hospital, Inc. | System and method for analyzing tissue intra-operatively using mass spectrometry |
| US9960028B2 (en) * | 2014-06-16 | 2018-05-01 | Purdue Research Foundation | Systems and methods for analyzing a sample from a surface |
| FR3026189B1 (fr) | 2014-09-22 | 2019-11-08 | Universite Des Sciences Et Technologies De Lille | Dispositif d'analyse moleculaire in vivo en temps reel |
| US9326838B1 (en) * | 2014-10-23 | 2016-05-03 | The North Umpqua Foundation | Fish DNA sampler |
| CA2969251C (en) | 2014-12-08 | 2023-08-15 | Arash Zarrine-Afsar | System and method for enhanced mass spectrometry imaging |
| DE102014226903A1 (de) * | 2014-12-23 | 2016-06-23 | Olympus Winter & Ibe Gmbh | HF-Hilfsstoff, medizinisches System und Verfahren zum selektiven Behandeln von Krebsgewebe |
| JP6757730B2 (ja) * | 2014-12-31 | 2020-09-23 | フリューダイム カナダ インコーポレイテッド | マスサイトメトリーによる分析用の構造化生体試料 |
| CA2981085A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis |
| WO2016142674A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
| WO2016142693A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | In vivo endoscopic tissue identification tool |
| EP3570315B1 (en) | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| US11289320B2 (en) | 2015-03-06 | 2022-03-29 | Micromass Uk Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| WO2016142683A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Improved ionisation of gaseous samples |
| CN110706996B (zh) * | 2015-03-06 | 2023-08-11 | 英国质谱公司 | 用于改进电离的碰撞表面 |
| GB2598259B (en) * | 2015-03-06 | 2022-06-22 | Micromass Ltd | Cell Population Analysis |
| GB2551669B (en) * | 2015-03-06 | 2021-04-14 | Micromass Ltd | Physically guided rapid evaporative ionisation mass spectrometry ("Reims") |
| US11282688B2 (en) * | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
| EP3741303A3 (en) * | 2015-03-06 | 2020-12-30 | Micromass UK Limited | Chemically guided ambient ionisation mass spectrometry |
| EP3265821B1 (en) | 2015-03-06 | 2021-06-16 | Micromass UK Limited | Liquid trap or separator for electrosurgical applications |
| EP3265823B1 (en) | 2015-03-06 | 2020-05-06 | Micromass UK Limited | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| US10777397B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device |
| US10978284B2 (en) | 2015-03-06 | 2021-04-13 | Micromass Uk Limited | Imaging guided ambient ionisation mass spectrometry |
| EP3075321A1 (en) | 2015-04-03 | 2016-10-05 | Ryan, Maximillian Frederick | A system for generating data relating to a tissue core biopsy, and the use of the system to detect tissue abnormalities, in particular cancerous tissue, in a patient |
| US10591448B2 (en) | 2015-04-14 | 2020-03-17 | Waters Technologies Corporation | Structural elucidation of isotopically labeled analytes |
| WO2016196179A1 (en) | 2015-05-29 | 2016-12-08 | Waters Technologies Corporation | Essential nutrient ratio determination |
| DE102016109753B4 (de) | 2015-05-29 | 2024-06-27 | Waters Technologies Corporation | Bestimmung der freien und der gesamten fettsäuren mit hilfe der desorptions-ionisationsmassenspektrometrie |
| GB2544834A (en) | 2015-06-09 | 2017-05-31 | Waters Technologies Corp | Profile diagnositcs in personalized dermatology, dermatopathology and cosmetics |
| GB2545521B (en) | 2015-06-09 | 2018-11-07 | Waters Technologies Corp | Molecular diagnostics in personalized dermatology, dermatopathology and cosmetics |
| RU2598767C1 (ru) * | 2015-09-08 | 2016-09-27 | Федеральное государственное бюджетное учреждение "Приволжский федеральный медицинский исследовательский центр" Министерства здравоохранения Российской Федерации | Способ интраоперационной навигации при внутримозговых новообразованиях |
| WO2017049403A1 (en) | 2015-09-22 | 2017-03-30 | University Health Network | System and method for optimized mass spectrometry analysis |
| GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
| GB201521848D0 (en) * | 2015-12-11 | 2016-01-27 | Micromass Ltd | Feedback apparatus |
| WO2017109563A1 (en) * | 2015-12-21 | 2017-06-29 | Basf Plant Science Company Gmbh | Means and methods for determination of a metabolic state of a plant |
| TWI613442B (zh) | 2016-02-23 | 2018-02-01 | 國立清華大學 | 組織辨識方法以及用於組織辨識的生物感測器 |
| WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
| CN109429525A (zh) | 2016-04-14 | 2019-03-05 | 沃特世科技公司 | 使用表面解吸电离和质谱的快速认证 |
| TWI684006B (zh) * | 2016-04-15 | 2020-02-01 | 國立中山大學 | 人體可代謝物質的檢測方法與檢測系統 |
| EP3446326B1 (en) * | 2016-04-19 | 2023-12-27 | Micromass UK Limited | Transfer tube calibration |
| GB201609952D0 (en) | 2016-06-07 | 2016-07-20 | Micromass Ltd | Combined optical and mass spectral tissue ID probes |
| WO2017214718A2 (en) * | 2016-06-10 | 2017-12-21 | University Health Network | Soft ionization system and method of use thereof |
| US9786477B1 (en) * | 2016-06-30 | 2017-10-10 | Smiths Detection Inc. | Gas flow assisted ion transfer system with improved transfer efficiency |
| SG11201901866TA (en) * | 2016-09-02 | 2019-03-28 | Univ Texas | Collection probe and methods for the use thereof |
| CN110140335B (zh) * | 2016-11-10 | 2022-08-12 | 瑞典爱立信有限公司 | 用于改进递送性能的资源分段 |
| GB201702643D0 (en) * | 2017-02-17 | 2017-04-05 | Micromass Ltd | Analysis of food samples |
| KR102732327B1 (ko) * | 2017-02-21 | 2024-11-19 | 칼 짜이스 에스엠티 게엠베하 | 공정의 실시간 모니터링 방법 및 질량 분광계 |
| US11259892B2 (en) | 2017-03-10 | 2022-03-01 | Asensus Surgical Us, Inc. | Instrument for optical tissue interrogation |
| FI20175319A1 (en) * | 2017-04-06 | 2018-10-07 | Olfactomics Oy | Method and equipment for the analysis of biological samples |
| JP7025621B2 (ja) * | 2017-04-13 | 2022-02-25 | 国立大学法人山梨大学 | 質量分析装置及び質量分析方法、並びに解析装置及び解析方法 |
| KR102086716B1 (ko) * | 2017-07-10 | 2020-03-09 | 재단법인대구경북과학기술원 | 살아있는 생체 시료의 분석을 위한 고해상도 대기압 질량분석 이미징 시스템 및 이의 용도 |
| JP7105049B2 (ja) * | 2017-10-02 | 2022-07-22 | 日本電子株式会社 | 質量分析データ処理装置、及び質量分析データ処理方法 |
| CN109841482B (zh) * | 2017-11-27 | 2020-07-21 | 中国科学院大连化学物理研究所 | 一种液体样品中挥发性有机物的富集采样和电离装置 |
| BR112020010416A2 (pt) * | 2017-11-27 | 2020-12-15 | Board Of Regents, The University Of Texas System | Sonda de coleta minimamente invasiva e métodos para o seu uso |
| CN110085507B (zh) * | 2018-01-26 | 2024-03-26 | 广州禾信仪器股份有限公司 | 敞开式离子源系统和质谱仪 |
| CN112020638A (zh) * | 2018-04-25 | 2020-12-01 | 加利福尼亚大学董事会 | 使用具有紫外表面激发的显微镜检查对组织的组织学层面三维成像 |
| US11219393B2 (en) | 2018-07-12 | 2022-01-11 | Trace Matters Scientific Llc | Mass spectrometry system and method for analyzing biological samples |
| US12089932B2 (en) | 2018-06-05 | 2024-09-17 | Trace Matters Scientific Llc | Apparatus, system, and method for transferring ions |
| US11087956B2 (en) * | 2018-06-29 | 2021-08-10 | Taiwan Semiconductor Manufacturing Co., Ltd. | Detection systems in semiconductor metrology tools |
| GB201815123D0 (en) * | 2018-09-17 | 2018-10-31 | Micromass Ltd | Tissue analysis |
| RU2702112C1 (ru) * | 2019-02-14 | 2019-10-04 | Федеральное государственное бюджетное учреждение "Институт теоретической и экспериментальной физики имени А.И. Алиханова Национального исследовательского центра "Курчатовский институт" | Способ восстановления масс для атомно-зондового томографа с лазерным испарением |
| CN109916881B (zh) * | 2019-03-07 | 2022-02-08 | 中国科学院上海硅酸盐研究所 | 激光剥蚀-大气压辉光放电原子发射光谱装置 |
| US11540883B2 (en) * | 2019-03-08 | 2023-01-03 | Thomas Jefferson University | Virtual reality training for medical events |
| AU2020240304A1 (en) * | 2019-03-21 | 2021-09-09 | C2Sense, Inc. | Systems for detection of volatile ions and related methods |
| CN111540665A (zh) * | 2020-04-20 | 2020-08-14 | 清华大学深圳国际研究生院 | 一种离子化装置及其应用 |
| IT202000013501A1 (it) | 2020-06-08 | 2021-12-08 | Univ Degli Studi Magna Graecia Di Catanzaro | Dispositivo chirurgico ultra-mininvasivo |
| CN113916968A (zh) * | 2020-06-24 | 2022-01-11 | 中国医学科学院药物研究所 | 一种用于样品快速分析鉴定的装置、系统及其应用和方法 |
| JP7865983B2 (ja) | 2021-03-12 | 2026-05-26 | ストライカー・ユーロピアン・オペレーションズ・リミテッド | 腫瘍組織を検出および除去するための神経外科的方法およびシステム |
| US12569138B2 (en) | 2021-04-02 | 2026-03-10 | Stryker European Operations Limited | Methods and systems for analyzing surgical smoke using atomic absorption spectroscopy |
| EP4190228B1 (de) | 2021-12-03 | 2026-03-25 | Erbe Elektromedizin GmbH | Einrichtung zur gewebeidentifikation |
| CN113984870B (zh) * | 2021-12-24 | 2022-03-22 | 北京凯世通半导体有限公司 | 一种通过sims对超低温离子注入设备监测的方法 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177100A (zh) * | 1996-09-19 | 1998-03-25 | 日本钢管株式会社 | 分析固体样品的方法和设备 |
| CN2565023Y (zh) * | 2002-06-20 | 2003-08-06 | 中国科学院广州地球化学研究所 | 大气细粒子连续液化采集传输装置 |
| US20040108454A1 (en) * | 2001-10-03 | 2004-06-10 | Bandy Alan R. | Negative ion atmospheric pressure ionization and selected ion mass spectrometry using a 63Ni electron source |
| US20060255261A1 (en) * | 2005-04-04 | 2006-11-16 | Craig Whitehouse | Atmospheric pressure ion source for mass spectrometry |
| WO2007012319A1 (de) * | 2005-07-29 | 2007-02-01 | Sigma-Aldrich Production Gmbh | Ionisierungsadditive enthaltende lc/ms-blends |
| WO2007138371A2 (en) * | 2006-05-31 | 2007-12-06 | Semmelweis Egyetem | Method and device for desorption ionization by liquid jet |
| CN101149326A (zh) * | 2006-09-21 | 2008-03-26 | 中国科学院生态环境研究中心 | 真空紫外光电离气溶胶质谱仪 |
| US20080149822A1 (en) * | 2005-01-27 | 2008-06-26 | Akos Vertes | Protein Microscope |
| CN101290304A (zh) * | 2007-04-17 | 2008-10-22 | 中国科学院生态环境研究中心 | 基质辅助激光解吸电离生物气溶胶质谱仪 |
Family Cites Families (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3479545A (en) | 1967-05-16 | 1969-11-18 | Hughes Aircraft Co | Surface ionization apparatus and electrode means for accelerating the ions in a curved path |
| JPS5988141A (ja) * | 1982-11-12 | 1984-05-22 | 株式会社日立製作所 | 試料ガス採取測定装置 |
| HU191642B (en) | 1984-03-21 | 1987-03-30 | Adam Kovacs | Method and instrument for discriminating from one another and separating by way of operation organic tissues |
| JPS6145957A (ja) * | 1984-08-10 | 1986-03-06 | Hitachi Ltd | 組織物抽出装置 |
| US4935624A (en) * | 1987-09-30 | 1990-06-19 | Cornell Research Foundation, Inc. | Thermal-assisted electrospray interface (TAESI) for LC/MS |
| US5779698A (en) | 1989-01-18 | 1998-07-14 | Applied Medical Resources Corporation | Angioplasty catheter system and method for making same |
| US5843019A (en) * | 1992-01-07 | 1998-12-01 | Arthrocare Corporation | Shaped electrodes and methods for electrosurgical cutting and ablation |
| JP2785694B2 (ja) * | 1994-08-10 | 1998-08-13 | 三菱マテリアル株式会社 | 蒸気圧の高い有機金属化学蒸着による銀薄膜形成用有機銀化合物 |
| JP3415682B2 (ja) | 1994-08-10 | 2003-06-09 | 株式会社日立製作所 | キャピラリー電気泳動・質量分析計 |
| US5559326A (en) | 1995-07-28 | 1996-09-24 | Hewlett-Packard Company | Self generating ion device for mass spectrometry of liquids |
| EP0819937A3 (en) * | 1996-07-19 | 2000-03-29 | The University Of Nottingham | Apparatus and methods for the analysis of trace constituents in gases |
| JPH1151902A (ja) | 1997-08-05 | 1999-02-26 | Jeol Ltd | Ｌｃ／ｍｓインターフェイス |
| US5920068A (en) | 1998-03-05 | 1999-07-06 | Micron Technology, Inc. | Analysis of semiconductor surfaces by secondary ion mass spectrometry |
| US7329253B2 (en) | 2003-12-09 | 2008-02-12 | Rubicor Medical, Inc. | Suction sleeve and interventional devices having such a suction sleeve |
| DE19982697D2 (de) * | 1998-12-14 | 2002-01-31 | Deutsches Krebsforsch | Verfahren und Vorrichtungen zum Aufbringen von Substanzen auf einen Träger, insbesondere von monomeren für die kombinatorische Synthese von Molekülbibliotheken |
| EP1153282A2 (de) * | 1998-12-14 | 2001-11-14 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen |
| US7119342B2 (en) | 1999-02-09 | 2006-10-10 | Syagen Technology | Interfaces for a photoionization mass spectrometer |
| US6135998A (en) * | 1999-03-16 | 2000-10-24 | Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for pulsed plasma-mediated electrosurgery in liquid media |
| US6280302B1 (en) | 1999-03-24 | 2001-08-28 | Flow International Corporation | Method and apparatus for fluid jet formation |
| US6375635B1 (en) | 1999-05-18 | 2002-04-23 | Hydrocision, Inc. | Fluid jet surgical instruments |
| US6531318B1 (en) | 1999-10-08 | 2003-03-11 | The General Hospital Corporation | Methods and apparatus for cell analysis |
| US6777672B1 (en) | 2000-02-18 | 2004-08-17 | Bruker Daltonics, Inc. | Method and apparatus for a multiple part capillary device for use in mass spectrometry |
| EP1296601B1 (de) | 2000-06-20 | 2006-08-02 | Medaxis Ag | Einrichtung zur erzeugung eines flüssigkeitsstrahles für das entfernen insbesondere von biologischem gewebe |
| AU2001288270A1 (en) | 2000-08-16 | 2002-02-25 | Vanderbilt University | System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels |
| CA2364676C (en) | 2000-12-08 | 2010-07-27 | Mds Inc., Doing Business As Mds Sciex | Ion mobility spectrometer incorporating an ion guide in combination with an ms device |
| US20030119193A1 (en) | 2001-04-25 | 2003-06-26 | Robert Hess | System and method for high throughput screening of droplets |
| JP3725803B2 (ja) | 2001-06-15 | 2005-12-14 | 株式会社東芝 | 半導体ウエハの不純物の測定方法及び半導体ウエハの不純物の測定プログラム |
| EP1291659A3 (en) | 2001-09-06 | 2008-05-21 | Sysmex Corporation | Automatic sample analyzer and its components |
| JP2003107054A (ja) | 2001-10-01 | 2003-04-09 | Shimadzu Corp | 液体クロマトグラフ質量分析装置 |
| WO2003031931A2 (en) | 2001-10-05 | 2003-04-17 | Yale University | Method and apparatus to produce ions and nanodrops from taylor cones of volatile liquids at reduced pressures |
| US6756586B2 (en) | 2001-10-15 | 2004-06-29 | Vanderbilt University | Methods and apparatus for analyzing biological samples by mass spectrometry |
| EP1448769A4 (en) | 2001-10-31 | 2006-02-01 | Ionfinity Llc | DEVICE FOR SOFT IONIZATION AND APPLICATIONS THEREFOR |
| US7005633B2 (en) | 2002-02-08 | 2006-02-28 | Ionalytics Corporation | Method and apparatus for desolvating ions for introduction into a FAIMS analyzer region |
| JP2003247920A (ja) * | 2002-02-26 | 2003-09-05 | Tdk Corp | 軽元素を含有する固体試料の組成比分析方法 |
| DK1499648T3 (en) | 2002-04-26 | 2015-02-09 | Total Res & Technology Feluy | PROVISION OF CONSOLIDATION AREAS IN A WEB, AND A WEB COVERING SUCH AREAS |
| WO2004030024A2 (en) * | 2002-05-31 | 2004-04-08 | University Of Florida Research Foundation, Inc. | Methods and devices for laser desorption chemical ionization |
| WO2004034011A2 (en) | 2002-10-10 | 2004-04-22 | Universita' Degli Studi Di Milano | Ionization source for mass spectrometry analysis |
| DE50312628D1 (de) | 2002-10-17 | 2010-05-27 | Braun Gmbh | Munddusche und sprühdüse zur erzeugung eines flüssigkeitsstrahls sowie zahnreinigungssystem |
| JP2004212073A (ja) | 2002-12-27 | 2004-07-29 | Hitachi Ltd | 危険物探知装置及び危険物探知方法 |
| JP2004264043A (ja) | 2003-01-31 | 2004-09-24 | National Institute Of Advanced Industrial & Technology | イオン化装置および微小領域分析装置 |
| KR100466866B1 (ko) | 2003-04-24 | 2005-01-24 | 전명기 | 생체조직을 응고괴사시키는 고주파 전기수술기용 전극 |
| US10191028B1 (en) * | 2003-06-06 | 2019-01-29 | Ionwerks | Inorganic nanoparticle matrices for sample analysis |
| US7684934B2 (en) * | 2003-06-06 | 2010-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pattern recognition of whole cell mass spectra |
| CA2470452C (en) | 2003-06-09 | 2017-10-03 | Ionics Mass Spectrometry Group, Inc. | Mass spectrometer interface |
| US7153203B2 (en) | 2003-07-21 | 2006-12-26 | Fmc Technologies, Inc. | Apparatus and method for portioning using automatic workpiece conveyance speed control |
| US20050017091A1 (en) | 2003-07-22 | 2005-01-27 | Omax Corporation | Abrasive water-jet cutting nozzle having a vented water-jet pathway |
| US20050077644A1 (en) | 2003-08-14 | 2005-04-14 | Bryan David E. | High pressure liquid jet cutting system and method for forming polymer pellets |
| US20050112650A1 (en) | 2003-10-20 | 2005-05-26 | Ciphergen Biosystems, Inc. | Reactive polyurethane-based polymers |
| US7217919B2 (en) | 2004-11-02 | 2007-05-15 | Analytica Of Branford, Inc. | Method and apparatus for multiplexing plural ion beams to a mass spectrometer |
| US7260914B2 (en) | 2003-12-27 | 2007-08-28 | Floral Transport Systems, Llc | Method and apparatus for packaging horticultural products |
| AU2005200016B2 (en) | 2004-01-09 | 2010-12-09 | John Bean Technologies Corporation | Method and system for portioning workpieces to user-scanned shape and other specifications |
| US20070023631A1 (en) | 2004-03-30 | 2007-02-01 | Zoltan Takats | Parallel sample handling for high-throughput mass spectrometric analysis |
| US7335897B2 (en) | 2004-03-30 | 2008-02-26 | Purdue Research Foundation | Method and system for desorption electrospray ionization |
| US7199364B2 (en) | 2004-05-21 | 2007-04-03 | Thermo Finnigan Llc | Electrospray ion source apparatus |
| JP3808482B2 (ja) | 2004-07-26 | 2006-08-09 | 株式会社日立製作所 | イオン源、質量分析方法及び質量分析計 |
| US20080262321A1 (en) | 2004-08-06 | 2008-10-23 | Ramot At Tel Aviv University Ltd. | Early Detection of Harmful Agents: Method, System and Kit |
| US7094135B2 (en) | 2004-08-10 | 2006-08-22 | International Waterjet Parts, Inc. | Abrasivejet cutting head with back-flow prevention valve |
| DE102004053064B4 (de) | 2004-11-03 | 2007-11-08 | Bruker Daltonik Gmbh | Ionisierung durch Tröpfchenaufprall |
| US6998622B1 (en) | 2004-11-17 | 2006-02-14 | Agilent Technologies, Inc. | On-axis electron impact ion source |
| IL166115A (en) | 2005-01-03 | 2012-06-28 | Dan Adam | Depth measurement, the sound is based on sound for medical applications |
| US7138626B1 (en) * | 2005-05-05 | 2006-11-21 | Eai Corporation | Method and device for non-contact sampling and detection |
| US7196525B2 (en) | 2005-05-06 | 2007-03-27 | Sparkman O David | Sample imaging |
| US7351960B2 (en) | 2005-05-16 | 2008-04-01 | Thermo Finnigan Llc | Enhanced ion desolvation for an ion mobility spectrometry device |
| US20070023677A1 (en) | 2005-06-29 | 2007-02-01 | Perkins Patrick D | Multimode ionization source and method for screening molecules |
| US20070046934A1 (en) * | 2005-08-26 | 2007-03-01 | New Wave Research, Inc. | Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method |
| US20070110666A1 (en) | 2005-09-30 | 2007-05-17 | Paul Pevsner | Methods for preparation of live body tissues for examination |
| US7828948B1 (en) | 2005-10-06 | 2010-11-09 | Sandia Corporation | Preconcentration and separation of analytes in microchannels |
| US20070094389A1 (en) | 2005-10-23 | 2007-04-26 | Bill Nussey | Provision of rss feeds based on classification of content |
| US7459676B2 (en) | 2005-11-21 | 2008-12-02 | Thermo Finnigan Llc | MALDI/LDI source |
| JP2007170870A (ja) | 2005-12-19 | 2007-07-05 | Protosera Inc | 質量分析を用いたｉｎｓｉｔｕ検出方法 |
| RU2328213C2 (ru) * | 2005-12-26 | 2008-07-10 | Общество с ограниченной ответственностью "МедМассСпектр" | Способ неинвазивного сбора и анализа транскутантного газа из живого организма в режиме реального времени |
| TWI271771B (en) * | 2006-01-27 | 2007-01-21 | Univ Nat Sun Yat Sen | Electrospray-assisted laser desorption ionization devices, mass spectrometers, and methods for mass spectrometry |
| US7687772B2 (en) | 2006-01-27 | 2010-03-30 | National Sun Yat-Sen University | Mass spectrometric imaging method under ambient conditions using electrospray-assisted laser desorption ionization mass spectrometry |
| US7462824B2 (en) | 2006-04-28 | 2008-12-09 | Yang Wang | Combined ambient desorption and ionization source for mass spectrometry |
| JP4818981B2 (ja) * | 2006-04-28 | 2011-11-16 | 独立行政法人産業技術総合研究所 | 細胞の迅速識別方法及び識別装置 |
| EP1855306B1 (en) | 2006-05-11 | 2019-11-13 | ISB - Ion Source & Biotechnologies S.R.L. | Ionization source and method for mass spectrometry |
| EP2035121A4 (en) * | 2006-05-26 | 2010-04-28 | Ionsense Inc | DEVICE FOR HOLDING SOLIDS FOR USE WITH SURFACE TREATMENT TECHNOLOGY |
| JP5142580B2 (ja) | 2006-06-29 | 2013-02-13 | キヤノン株式会社 | 表面解析方法および表面解析装置 |
| WO2008073146A2 (en) * | 2006-07-06 | 2008-06-19 | University Of Wyoming | Method and apparatus for pyrolysis-induced cleavage in peptides and proteins |
| EP2040824A2 (en) | 2006-07-11 | 2009-04-01 | Excellims Corporation | Methods and apparatus for the ion mobility based separation and collection of molecules |
| US7928364B2 (en) | 2006-10-13 | 2011-04-19 | Ionsense, Inc. | Sampling system for containment and transfer of ions into a spectroscopy system |
| JP2008147165A (ja) | 2006-10-30 | 2008-06-26 | National Sun Yat-Sen Univ | レーザー脱離装置、マススペクトロメーター組立及び環境液体マススペクトロメトリー法 |
| US7718958B2 (en) | 2006-11-17 | 2010-05-18 | National Sun Yat-Sen University | Mass spectroscopic reaction-monitoring method |
| US20090065714A1 (en) | 2006-11-30 | 2009-03-12 | Keady John P | Eletrofluid collisional accelerator and fusion reactor |
| WO2008115855A1 (en) | 2007-03-16 | 2008-09-25 | Inficon, Inc. | Portable light emitting sampling probe |
| US7564028B2 (en) | 2007-05-01 | 2009-07-21 | Virgin Instruments Corporation | Vacuum housing system for MALDI-TOF mass spectrometry |
| US20080312651A1 (en) | 2007-06-15 | 2008-12-18 | Karl Pope | Apparatus and methods for selective heating of tissue |
| US8901487B2 (en) | 2007-07-20 | 2014-12-02 | George Washington University | Subcellular analysis by laser ablation electrospray ionization mass spectrometry |
| US20100186524A1 (en) | 2008-02-05 | 2010-07-29 | Enertechnix, Inc | Aerosol Collection and Microdroplet Delivery for Analysis |
| US20100096546A1 (en) | 2008-06-23 | 2010-04-22 | Northrop Grumman Systems Corporation | Solution Analysis Using Atmospheric Pressure Ionization Techniques |
| JP5098079B2 (ja) | 2008-06-27 | 2012-12-12 | 国立大学法人山梨大学 | イオン化分析方法および装置 |
| US20100280409A1 (en) | 2008-09-30 | 2010-11-04 | Mark Joseph L | Real-time pathology |
| WO2010039675A1 (en) | 2008-09-30 | 2010-04-08 | Prosolia, Inc. | Method and apparatus for embedded heater for desorption and ionization of analytes |
| JP5725620B2 (ja) * | 2008-10-13 | 2015-05-27 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 分析のためのイオン移動のためのシステムおよび方法 |
| WO2010114976A1 (en) * | 2009-04-01 | 2010-10-07 | Prosolia, Inc. | Method and system for surface sampling |
| EP2435814B1 (en) | 2009-05-27 | 2017-09-27 | Micromass UK Limited | System and method for identification of biological tissues |
| DE102009050040B4 (de) | 2009-08-28 | 2014-10-30 | Bruker Daltonik Gmbh | Einlass von Ionen in Massenspektrometer durch Lavaldüsen |
| US8299444B2 (en) | 2009-09-02 | 2012-10-30 | Shimadzu Research Laboratory (Shanghai) Co. Ltd. | Ion source |
| GB2466350B (en) | 2009-11-30 | 2011-06-08 | Microsaic Systems Ltd | Mass spectrometer system |
| US8591459B2 (en) | 2009-12-21 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Use of biomarkers and therapeutic agents with surgical devices |
| JP5521177B2 (ja) | 2010-04-28 | 2014-06-11 | 株式会社島津製作所 | 質量分析装置 |
-
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Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1177100A (zh) * | 1996-09-19 | 1998-03-25 | 日本钢管株式会社 | 分析固体样品的方法和设备 |
| US20040108454A1 (en) * | 2001-10-03 | 2004-06-10 | Bandy Alan R. | Negative ion atmospheric pressure ionization and selected ion mass spectrometry using a 63Ni electron source |
| CN2565023Y (zh) * | 2002-06-20 | 2003-08-06 | 中国科学院广州地球化学研究所 | 大气细粒子连续液化采集传输装置 |
| US20080149822A1 (en) * | 2005-01-27 | 2008-06-26 | Akos Vertes | Protein Microscope |
| US20060255261A1 (en) * | 2005-04-04 | 2006-11-16 | Craig Whitehouse | Atmospheric pressure ion source for mass spectrometry |
| WO2007012319A1 (de) * | 2005-07-29 | 2007-02-01 | Sigma-Aldrich Production Gmbh | Ionisierungsadditive enthaltende lc/ms-blends |
| WO2007138371A2 (en) * | 2006-05-31 | 2007-12-06 | Semmelweis Egyetem | Method and device for desorption ionization by liquid jet |
| CN101149326A (zh) * | 2006-09-21 | 2008-03-26 | 中国科学院生态环境研究中心 | 真空紫外光电离气溶胶质谱仪 |
| CN101290304A (zh) * | 2007-04-17 | 2008-10-22 | 中国科学院生态环境研究中心 | 基质辅助激光解吸电离生物气溶胶质谱仪 |
Non-Patent Citations (2)
| Title |
|---|
| ZOLTAN: ""Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization"", 《SCIENCE》 * |
| 鲁焕章: "《激光医疗手册》", 31 January 1991 * |
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