CN1099752A - 新型酰氨烷基-和亚氨烷基-哌嗪 - Google Patents

新型酰氨烷基-和亚氨烷基-哌嗪 Download PDF

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Publication number
CN1099752A
CN1099752A CN93118820A CN93118820A CN1099752A CN 1099752 A CN1099752 A CN 1099752A CN 93118820 A CN93118820 A CN 93118820A CN 93118820 A CN93118820 A CN 93118820A CN 1099752 A CN1099752 A CN 1099752A
Authority
CN
China
Prior art keywords
compound
general formula
hydrogen atom
definition
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93118820A
Other languages
English (en)
Chinese (zh)
Inventor
S·本特森
L·弗罗瓦尔
D·杰克森
B·R·托尔夫
C·阿克森
G·哈尔内莫
S·罗斯
B·乌尔夫
L·张
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SE9201138A priority Critical patent/SE9201138D0/xx
Priority to CA002109816A priority patent/CA2109816A1/en
Priority to SK1389-93A priority patent/SK138993A3/sk
Priority to JP5518225A priority patent/JPH06508378A/ja
Priority to AU39643/93A priority patent/AU665825B2/en
Priority to EP93909109A priority patent/EP0594813A1/en
Priority to CZ932701A priority patent/CZ270193A3/cs
Priority to HU9303520A priority patent/HUT68891A/hu
Priority to PCT/SE1993/000295 priority patent/WO1993021179A1/en
Priority to SI9300191A priority patent/SI9300191A/sl
Priority to CN93118820A priority patent/CN1099752A/zh
Application filed by Astra AB filed Critical Astra AB
Priority to NO934426A priority patent/NO180794C/no
Priority to NO934426D priority patent/NO934426D0/no
Priority to FI935494A priority patent/FI935494A0/fi
Priority to BG98281A priority patent/BG98281A/xx
Publication of CN1099752A publication Critical patent/CN1099752A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN93118820A 1992-04-09 1993-08-31 新型酰氨烷基-和亚氨烷基-哌嗪 Pending CN1099752A (zh)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9201138A SE9201138D0 (sv) 1992-04-09 1992-04-09 Novel phthalimidoalkylpiperazines
EP93909109A EP0594813A1 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
PCT/SE1993/000295 WO1993021179A1 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
AU39643/93A AU665825B2 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
SK1389-93A SK138993A3 (en) 1992-04-09 1993-04-06 Amidoalkyl - and imidoalkylpiperazines
CZ932701A CZ270193A3 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl piperazines
HU9303520A HUT68891A (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
CA002109816A CA2109816A1 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
JP5518225A JPH06508378A (ja) 1992-04-09 1993-04-06 新規アミドアルキル−およびイミドアルキル−ピペラジン類
SI9300191A SI9300191A (sl) 1992-04-09 1993-04-09 Novi amidoalkil- in imidoalkil-piperazini
CN93118820A CN1099752A (zh) 1992-04-09 1993-08-31 新型酰氨烷基-和亚氨烷基-哌嗪
NO934426A NO180794C (no) 1992-04-09 1993-12-06 Nye amidoalkyl- og imidoalkylpiperaziner samt farmasöytisk preparat inneholdende slike forbindelser
NO934426D NO934426D0 (no) 1992-04-09 1993-12-06 Nye amidoalkyl- og imidoalkylpipera-ziner
FI935494A FI935494A0 (fi) 1992-04-09 1993-12-08 Nya amidolakyl- och imidoalkylpiperaziner
BG98281A BG98281A (en) 1992-04-09 1993-12-08 Amidoalkyl- and imidoalkylpiperazines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201138A SE9201138D0 (sv) 1992-04-09 1992-04-09 Novel phthalimidoalkylpiperazines
CN93118820A CN1099752A (zh) 1992-04-09 1993-08-31 新型酰氨烷基-和亚氨烷基-哌嗪

Publications (1)

Publication Number Publication Date
CN1099752A true CN1099752A (zh) 1995-03-08

Family

ID=36869961

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93118820A Pending CN1099752A (zh) 1992-04-09 1993-08-31 新型酰氨烷基-和亚氨烷基-哌嗪

Country Status (14)

Country Link
EP (1) EP0594813A1 (fi)
JP (1) JPH06508378A (fi)
CN (1) CN1099752A (fi)
AU (1) AU665825B2 (fi)
BG (1) BG98281A (fi)
CA (1) CA2109816A1 (fi)
CZ (1) CZ270193A3 (fi)
FI (1) FI935494A0 (fi)
HU (1) HUT68891A (fi)
NO (2) NO934426D0 (fi)
SE (1) SE9201138D0 (fi)
SI (1) SI9300191A (fi)
SK (1) SK138993A3 (fi)
WO (1) WO1993021179A1 (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1948298B (zh) * 2006-11-09 2010-09-01 东南大学 一种多巴胺d3受体部分激动剂及其应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
FR2742149B1 (fr) * 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703235A (en) 1996-03-21 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands
CZ315098A3 (cs) * 1996-04-05 1999-04-14 Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) Antagonisté alfa1-adrenergických receptorů
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
CA2489396A1 (en) * 2002-07-04 2004-01-15 Schwarz Pharma Ag Utilization of heteroarene carboxamide as dopamine-d3 ligands for the treatment of cns diseases

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US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3488352A (en) * 1966-10-11 1970-01-06 Shulton Inc Basically substituted alkoxy anthranilamides,their corresponding 2-nitro compounds and derivatives thereof
US3505338A (en) * 1966-11-25 1970-04-07 American Cyanamid Co Thiophenecarbonylalkylene-diamines
FR1537901A (fr) * 1967-07-19 1968-08-30 Bruneau & Cie Lab Dérivés amidés d'acides halogéno et nitro benzoïques et leur préparation
US3558777A (en) * 1968-06-21 1971-01-26 Mead Johnson & Co Pharmacologic processes and compositions containing azaspirodecanediones and azaspiroundecanediones
US3465080A (en) * 1968-10-07 1969-09-02 American Cyanamid Co Therapeutic compositions containing morpholinoalkylene - indoles and methods of administering such in the treatment of depression
JPS504650B2 (fi) * 1971-09-03 1975-02-22
US3940397A (en) * 1974-11-13 1976-02-24 E. R. Squibb & Sons, Inc. 2-[(Substituted-piperazinyl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
NL8005133A (nl) * 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
DE3529872A1 (de) * 1985-08-21 1987-02-26 Kali Chemie Pharma Gmbh Neue tetraoxoverbindungen
US4892943A (en) * 1985-10-16 1990-01-09 American Home Products Corporation Fused bicyclic imides with psychotropic activity
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod History of piperazinyl carboxamide, their preparation and the pharmaceutical preparations containing them
US5071845A (en) * 1988-12-28 1991-12-10 Suntory Limited Benzoxazepine derivative
US4939137A (en) * 1989-06-28 1990-07-03 Ortho Pharmaceutical Corporation Ring-fused thienopyrimidinedione derivatives
CA2071897A1 (en) * 1989-12-28 1991-06-29 Richard A. Glennon Sigma receptor ligands and the use thereof
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
IT1251144B (it) * 1991-07-30 1995-05-04 Boehringer Ingelheim Italia Derivati del benzimidazolone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1948298B (zh) * 2006-11-09 2010-09-01 东南大学 一种多巴胺d3受体部分激动剂及其应用

Also Published As

Publication number Publication date
AU3964393A (en) 1993-11-18
WO1993021179A1 (en) 1993-10-28
NO934426L (no) 1993-12-06
JPH06508378A (ja) 1994-09-22
NO180794B (no) 1997-03-17
AU665825B2 (en) 1996-01-18
CA2109816A1 (en) 1993-10-28
EP0594813A1 (en) 1994-05-04
SK138993A3 (en) 1994-11-09
CZ270193A3 (en) 1994-08-17
SI9300191A (sl) 1993-12-31
NO180794C (no) 1997-06-25
NO934426D0 (no) 1993-12-06
SE9201138D0 (sv) 1992-04-09
FI935494A (fi) 1993-12-08
BG98281A (en) 1994-09-30
FI935494A0 (fi) 1993-12-08
HUT68891A (en) 1995-08-28

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C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication