BG98281A - Amidoalkyl- and imidoalkylpiperazines - Google Patents

Amidoalkyl- and imidoalkylpiperazines

Info

Publication number
BG98281A
BG98281A BG98281A BG9828193A BG98281A BG 98281 A BG98281 A BG 98281A BG 98281 A BG98281 A BG 98281A BG 9828193 A BG9828193 A BG 9828193A BG 98281 A BG98281 A BG 98281A
Authority
BG
Bulgaria
Prior art keywords
group
hydrogen atom
hydrogen
rings
compounds
Prior art date
Application number
BG98281A
Other languages
Bulgarian (bg)
Inventor
Stefan Bengtsson
Lennart Florvall
Gerd Hallnemo
David Jackson
Svante Ross
Bo-Ragnar Tolf
Bengt Ulff
Lian Zhang
Christina Akesson
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of BG98281A publication Critical patent/BG98281A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Съединения с обща формула в която r означава водороден атом или фенилова група, м е цяло число от 3 до 8, r4 означава nо2 група или групата nr7r8, в която r7 и r8 са еднакви или различнии всеки от тях представлява водород или алкил, r5 означава водород, халоген или сf3, r6 е халоген или сf3, w е евентуално заместен ароматен пръстен или пръстени, хетероцикличен пръстен, карбоцикличенпръстен или пръстени, или евентуално заместена метиленова група, а е водороден атом, хидроксилна група, халоген, сf3, алкилова група, алкоксигрупа, фенилова група или феноксигрупа, в е водороден атомили а и в заедно образуват карбонилна група, n1 е 0 или 1, n2 е 0 или 1, методи и междинни съединения за тяхното получаване, фармацевтични препарати, които ги съдържат, и приложение на съединенията при лечение на умствени смущения.Compounds of the general formula wherein r is a hydrogen atom or a phenyl group, m is an integer from 3 to 8, R4 is NO2 or NR7R8 wherein R7 and R8 are the same or different and each represents hydrogen or alkyl, hydrogen, halo or Cf3, R6 is halogen or with f3, w is an optionally substituted aromatic ring or rings, a heterocyclic ring, a carbocyclic ring or rings or an optionally substituted methylene group, a is a hydrogen atom, a hydroxyl group, a halogen atom, a C1-3 alkyl group, an alkoxy group , a phenyl group or a phenoxy group, is a hydrogen atom and together form a carbonyl group, n1 is 0 or 1, n2 is 0 or 1, and processes and intermediates for their preparation, pharmaceutical compositions containing them, and use of the compounds in the treatment of mental disorders.

BG98281A 1992-04-09 1993-12-08 Amidoalkyl- and imidoalkylpiperazines BG98281A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9201138A SE9201138D0 (en) 1992-04-09 1992-04-09 NOVEL PHTHALIMIDOALKYL PIPERAZINES
PCT/SE1993/000295 WO1993021179A1 (en) 1992-04-09 1993-04-06 Novel amidoalkyl- and imidoalkyl-piperazines
CN93118820A CN1099752A (en) 1992-04-09 1993-08-31 Novel amidoalkyl- and imidoalkyl-piperazines

Publications (1)

Publication Number Publication Date
BG98281A true BG98281A (en) 1994-09-30

Family

ID=36869961

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98281A BG98281A (en) 1992-04-09 1993-12-08 Amidoalkyl- and imidoalkylpiperazines

Country Status (14)

Country Link
EP (1) EP0594813A1 (en)
JP (1) JPH06508378A (en)
CN (1) CN1099752A (en)
AU (1) AU665825B2 (en)
BG (1) BG98281A (en)
CA (1) CA2109816A1 (en)
CZ (1) CZ270193A3 (en)
FI (1) FI935494A0 (en)
HU (1) HUT68891A (en)
NO (2) NO180794C (en)
SE (1) SE9201138D0 (en)
SI (1) SI9300191A (en)
SK (1) SK138993A3 (en)
WO (1) WO1993021179A1 (en)

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* Cited by examiner, † Cited by third party
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IT1266582B1 (en) * 1993-07-30 1997-01-09 Recordati Chem Pharm (DI) AZACYLO-HEXANIC AND DIAZACYLO-HEPTANIC DERIVATIVES
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
FR2742149B1 (en) * 1995-12-11 1998-02-13 Inst Nat Sante Rech Med NOVEL 2-NAPHTAMIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703235A (en) 1996-03-21 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands
ES2188936T3 (en) * 1996-04-05 2003-07-01 Sod Conseils Rech Applic ANTAGONISTS OF THE ALFA-Q-ADRENERGIC RECEIVER.
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
DK1519726T3 (en) * 2002-07-04 2007-06-04 Sanol Arznei Schwarz Gmbh Heteroarenecarboxamides for use as dopamine D3 ligands in the treatment of CNS disorders
CN1948298B (en) * 2006-11-09 2010-09-01 东南大学 Dopamine D3 acceptor portion agonist and its application

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US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
US3488352A (en) * 1966-10-11 1970-01-06 Shulton Inc Basically substituted alkoxy anthranilamides,their corresponding 2-nitro compounds and derivatives thereof
US3505338A (en) * 1966-11-25 1970-04-07 American Cyanamid Co Thiophenecarbonylalkylene-diamines
FR1537901A (en) * 1967-07-19 1968-08-30 Bruneau & Cie Lab Amide derivatives of halogeno and nitro benzoic acids and their preparation
US3558777A (en) * 1968-06-21 1971-01-26 Mead Johnson & Co Pharmacologic processes and compositions containing azaspirodecanediones and azaspiroundecanediones
US3465080A (en) * 1968-10-07 1969-09-02 American Cyanamid Co Therapeutic compositions containing morpholinoalkylene - indoles and methods of administering such in the treatment of depression
JPS504650B2 (en) * 1971-09-03 1975-02-22
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US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
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Also Published As

Publication number Publication date
CZ270193A3 (en) 1994-08-17
FI935494A (en) 1993-12-08
SE9201138D0 (en) 1992-04-09
NO934426D0 (en) 1993-12-06
WO1993021179A1 (en) 1993-10-28
FI935494A0 (en) 1993-12-08
NO934426L (en) 1993-12-06
CA2109816A1 (en) 1993-10-28
AU3964393A (en) 1993-11-18
EP0594813A1 (en) 1994-05-04
JPH06508378A (en) 1994-09-22
AU665825B2 (en) 1996-01-18
NO180794C (en) 1997-06-25
CN1099752A (en) 1995-03-08
HUT68891A (en) 1995-08-28
SK138993A3 (en) 1994-11-09
NO180794B (en) 1997-03-17
SI9300191A (en) 1993-12-31

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