CN109674753A - 固态分散体 - Google Patents
固态分散体 Download PDFInfo
- Publication number
- CN109674753A CN109674753A CN201910082228.2A CN201910082228A CN109674753A CN 109674753 A CN109674753 A CN 109674753A CN 201910082228 A CN201910082228 A CN 201910082228A CN 109674753 A CN109674753 A CN 109674753A
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- CN
- China
- Prior art keywords
- base
- ethyl
- tetrazolium
- compound
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007962 solid dispersion Substances 0.000 title claims abstract description 47
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 claims abstract description 74
- 239000000203 mixture Substances 0.000 claims abstract description 51
- 238000000034 method Methods 0.000 claims description 82
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 36
- 239000008103 glucose Substances 0.000 claims description 35
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 31
- 239000002585 base Substances 0.000 claims description 27
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- 210000004369 blood Anatomy 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 13
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 claims description 12
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 12
- 239000003513 alkali Substances 0.000 claims description 9
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 8
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35798110P | 2010-06-23 | 2010-06-23 | |
| US61/357,981 | 2010-06-23 | ||
| CN2011800283946A CN103037843A (zh) | 2010-06-23 | 2011-06-17 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800283946A Division CN103037843A (zh) | 2010-06-23 | 2011-06-17 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109674753A true CN109674753A (zh) | 2019-04-26 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910082228.2A Pending CN109674753A (zh) | 2010-06-23 | 2011-06-17 | 固态分散体 |
| CN2011800283946A Pending CN103037843A (zh) | 2010-06-23 | 2011-06-17 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
Family Applications After (1)
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| CN2011800283946A Pending CN103037843A (zh) | 2010-06-23 | 2011-06-17 | 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9241924B2 (enExample) |
| EP (1) | EP2585048B1 (enExample) |
| JP (1) | JP5847813B2 (enExample) |
| CN (2) | CN109674753A (enExample) |
| BR (1) | BR112012032248A2 (enExample) |
| CA (1) | CA2802541A1 (enExample) |
| ES (1) | ES2676209T3 (enExample) |
| WO (1) | WO2011163090A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CA2693169C (en) | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| CL2009000782A1 (es) * | 2008-03-31 | 2010-04-30 | Metabolex Inc | Metodo que comprende un compuesto derivado de oximetilen-arilo sustituido, inhibidores de dpp-iv; y su uso en el tratamiento de la diabetes y disminucion de trigliceridos, entre otras enfermedades. |
| US20110160222A1 (en) * | 2008-11-26 | 2011-06-30 | Metabolex, Inc. | Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders |
| CA2775840C (en) * | 2009-10-01 | 2018-02-06 | Metabolex, Inc. | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts |
| ES2676209T3 (es) | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| ES3041833T3 (en) * | 2013-12-31 | 2025-11-14 | Ascendia Pharmaceuticals Llc | Pharmaceutical compositions for poorly water-soluble compounds |
| JP6603242B2 (ja) * | 2014-06-11 | 2019-11-06 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | ピペリジン−４−カルボチオアミドの製造 |
| EP3493807A1 (en) | 2016-08-03 | 2019-06-12 | CymaBay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| EP4153589A4 (en) | 2020-05-19 | 2024-06-12 | Kallyope, Inc. | AMPK ACTIVATORS |
| WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
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2011
- 2011-06-17 ES ES11728490.1T patent/ES2676209T3/es active Active
- 2011-06-17 EP EP11728490.1A patent/EP2585048B1/en not_active Not-in-force
- 2011-06-17 CA CA2802541A patent/CA2802541A1/en not_active Abandoned
- 2011-06-17 CN CN201910082228.2A patent/CN109674753A/zh active Pending
- 2011-06-17 JP JP2013516636A patent/JP5847813B2/ja not_active Expired - Fee Related
- 2011-06-17 CN CN2011800283946A patent/CN103037843A/zh active Pending
- 2011-06-17 WO PCT/US2011/040972 patent/WO2011163090A1/en not_active Ceased
- 2011-06-17 BR BR112012032248A patent/BR112012032248A2/pt not_active Application Discontinuation
- 2011-06-21 US US13/165,651 patent/US9241924B2/en active Active
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2016
- 2016-01-21 US US15/002,498 patent/US10098843B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2585048B1 (en) | 2018-04-11 |
| US20160213618A1 (en) | 2016-07-28 |
| US20110318418A1 (en) | 2011-12-29 |
| US10098843B2 (en) | 2018-10-16 |
| BR112012032248A2 (pt) | 2016-09-13 |
| CA2802541A1 (en) | 2011-12-29 |
| JP2013529637A (ja) | 2013-07-22 |
| WO2011163090A1 (en) | 2011-12-29 |
| US9241924B2 (en) | 2016-01-26 |
| EP2585048A1 (en) | 2013-05-01 |
| ES2676209T3 (es) | 2018-07-17 |
| JP5847813B2 (ja) | 2016-01-27 |
| CN103037843A (zh) | 2013-04-10 |
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