ES2676209T3 - Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina - Google Patents
Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina Download PDFInfo
- Publication number
- ES2676209T3 ES2676209T3 ES11728490.1T ES11728490T ES2676209T3 ES 2676209 T3 ES2676209 T3 ES 2676209T3 ES 11728490 T ES11728490 T ES 11728490T ES 2676209 T3 ES2676209 T3 ES 2676209T3
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- Prior art keywords
- compound
- tetrazol
- weight
- pyrimidine
- ethyl
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- NFTMKHWBOINJGM-UHFFFAOYSA-N 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole Chemical group N1=CC(CC)=CN=C1N1CCC(C=2SC=C(COC=3C=CC(=CC=3)N3N=NN=C3)N=2)CC1 NFTMKHWBOINJGM-UHFFFAOYSA-N 0.000 title claims abstract description 56
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35798110P | 2010-06-23 | 2010-06-23 | |
| US357981P | 2010-06-23 | ||
| PCT/US2011/040972 WO2011163090A1 (en) | 2010-06-23 | 2011-06-17 | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2676209T3 true ES2676209T3 (es) | 2018-07-17 |
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| Application Number | Title | Priority Date | Filing Date |
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Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9241924B2 (enExample) |
| EP (1) | EP2585048B1 (enExample) |
| JP (1) | JP5847813B2 (enExample) |
| CN (2) | CN109674753A (enExample) |
| BR (1) | BR112012032248A2 (enExample) |
| CA (1) | CA2802541A1 (enExample) |
| ES (1) | ES2676209T3 (enExample) |
| WO (1) | WO2011163090A1 (enExample) |
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| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AU2008279447A1 (en) | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| AU2009231906A1 (en) * | 2008-03-31 | 2009-10-08 | Metabolex, Inc. | Oxymethylene aryl compounds and uses thereof |
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| JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス， インコーポレーテッド | 置換テトラゾール−１−イルフェノキシメチルチアゾール−２−イルピペリジニルピリミジン塩 |
| JP5847813B2 (ja) | 2010-06-23 | 2016-01-27 | シマベイ セラピューティクス， インコーポレーテッド | ５−エチル−２−｛４−［４−（４−テトラゾル−１−イル−フェノキシメチル）−チアゾール−２−イル］−ピペリジン−１−イル｝−ピリミジンの組成物 |
| EP3089736B1 (en) * | 2013-12-31 | 2025-07-23 | Ascendia Pharmaceuticals, LLC | Pharmaceutical compositions for poorly water-soluble compounds |
| KR102430612B1 (ko) * | 2014-06-11 | 2022-08-08 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 피페리딘-4-카보티오아미드의 제조 |
| AU2017305392A1 (en) * | 2016-08-03 | 2019-02-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
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-
2011
- 2011-06-17 JP JP2013516636A patent/JP5847813B2/ja not_active Expired - Fee Related
- 2011-06-17 CN CN201910082228.2A patent/CN109674753A/zh active Pending
- 2011-06-17 ES ES11728490.1T patent/ES2676209T3/es active Active
- 2011-06-17 WO PCT/US2011/040972 patent/WO2011163090A1/en not_active Ceased
- 2011-06-17 CA CA2802541A patent/CA2802541A1/en not_active Abandoned
- 2011-06-17 EP EP11728490.1A patent/EP2585048B1/en not_active Not-in-force
- 2011-06-17 BR BR112012032248A patent/BR112012032248A2/pt not_active Application Discontinuation
- 2011-06-17 CN CN2011800283946A patent/CN103037843A/zh active Pending
- 2011-06-21 US US13/165,651 patent/US9241924B2/en active Active
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2016
- 2016-01-21 US US15/002,498 patent/US10098843B2/en active Active
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| Publication number | Publication date |
|---|---|
| US20160213618A1 (en) | 2016-07-28 |
| CN103037843A (zh) | 2013-04-10 |
| US20110318418A1 (en) | 2011-12-29 |
| US9241924B2 (en) | 2016-01-26 |
| JP5847813B2 (ja) | 2016-01-27 |
| JP2013529637A (ja) | 2013-07-22 |
| EP2585048A1 (en) | 2013-05-01 |
| US10098843B2 (en) | 2018-10-16 |
| EP2585048B1 (en) | 2018-04-11 |
| WO2011163090A1 (en) | 2011-12-29 |
| CA2802541A1 (en) | 2011-12-29 |
| CN109674753A (zh) | 2019-04-26 |
| BR112012032248A2 (pt) | 2016-09-13 |
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