CN109602944A - 原位可交联的聚合物组合物及其方法 - Google Patents
原位可交联的聚合物组合物及其方法 Download PDFInfo
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- CN109602944A CN109602944A CN201811325132.6A CN201811325132A CN109602944A CN 109602944 A CN109602944 A CN 109602944A CN 201811325132 A CN201811325132 A CN 201811325132A CN 109602944 A CN109602944 A CN 109602944A
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Cited By (2)
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| CN111303453A (zh) * | 2020-03-09 | 2020-06-19 | 中国海洋大学 | 一种多重敏感型水凝胶聚合物的制备方法和应用 |
| CN115887738A (zh) * | 2022-12-16 | 2023-04-04 | 湖南师范大学 | 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| WO2009094060A1 (en) | 2008-01-24 | 2009-07-30 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| WO2011149907A1 (en) | 2010-05-24 | 2011-12-01 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| EP2637708A2 (en) | 2010-11-12 | 2013-09-18 | University of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| CA2855347C (en) | 2011-11-13 | 2019-03-05 | Suneris Inc. | In-situ cross-linkable polymeric compositions and methods thereof |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| ITTO20130375A1 (it) * | 2013-05-10 | 2014-11-11 | Marco Benzi | Prodotto per l'uso per il trattamento terapeutico di parodontopatie e perimplantiti |
| CN103611180B (zh) * | 2013-11-21 | 2015-02-18 | 无锡中科光远生物材料有限公司 | 一种自粘止血防粘连纤维体的制备方法 |
| EP3166550B1 (en) | 2014-07-11 | 2023-12-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Surgical tool for ocular tissue transplantation |
| EP3169374B1 (en) | 2014-07-14 | 2022-01-05 | University of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| MX2017016865A (es) * | 2015-06-22 | 2018-09-06 | Cresilon Inc | Andamio de polimero adhesivo hermostatico altamente eficaz. |
| JP7493961B2 (ja) * | 2015-06-22 | 2024-06-03 | クレシロン， インコーポレイテッド | 高度に有用な止血用接着性ポリマー足場 |
| US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
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| CN105030815B (zh) * | 2015-08-10 | 2019-03-15 | 贵州扬生医用器材有限公司 | 一种手术冲洗液及其制法 |
| US11065337B2 (en) | 2015-12-14 | 2021-07-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Complex coacervate for controlled release and related methods |
| KR101666792B1 (ko) | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
| WO2017152039A1 (en) | 2016-03-04 | 2017-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Protection and delivery of multiple therapeutic proteins |
| CN105860107B (zh) * | 2016-04-26 | 2018-02-09 | 中南大学 | 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法 |
| KR101916193B1 (ko) * | 2016-08-25 | 2018-11-07 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 관절강 주사용 조성물 |
| WO2018128704A2 (en) | 2016-11-07 | 2018-07-12 | 3M Innovative Properties Company | Medical composition containing guanidinyl-containing polymer(s) and carrageenane(s) |
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| JP6939607B2 (ja) * | 2017-03-27 | 2021-09-22 | Jsr株式会社 | 組成物およびその用途 |
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| KR102218427B1 (ko) * | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
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| RU2675631C1 (ru) * | 2018-10-02 | 2018-12-21 | Общество с ограниченной ответственностью "Новые Биомедицинские Решения" | Местное гемостатическое средство с повышенной антимикробной активностью |
| EP3946480A1 (en) | 2019-04-03 | 2022-02-09 | DTech - Società a Responsabilità Limitata | Two-component system for the therapeutic treatment of skin lesions and production method thereof |
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| EP3925636A1 (en) | 2020-06-17 | 2021-12-22 | Centre Of Experimental Medicine Slovak Academy Of Sciences Institute Of Experimental Pharmacology | Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof |
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Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5836970A (en) * | 1996-08-02 | 1998-11-17 | The Kendall Company | Hemostatic wound dressing |
| JP2000116765A (ja) * | 1998-10-15 | 2000-04-25 | Kuraray Co Ltd | 癒着防止用材料 |
| JP2000186048A (ja) * | 1998-12-22 | 2000-07-04 | Kuraray Co Ltd | 止血材 |
| US20030232746A1 (en) * | 2002-02-21 | 2003-12-18 | Encelle, Inc. | Cross-linked bioactive hydrogel matrices |
| CN1883721A (zh) * | 2006-06-21 | 2006-12-27 | 哈尔滨工业大学 | 共价交联凝胶改性人工植入体的方法 |
| CN101001649A (zh) * | 2004-07-09 | 2007-07-18 | 弗罗桑公司 | 包括透明质酸的止血组合物 |
| US20070166351A1 (en) * | 2002-06-21 | 2007-07-19 | Advanced Cardiovascular Systems, Inc. | Polycationic peptides for cardiovascular therapy |
| US20070237811A1 (en) * | 2006-04-10 | 2007-10-11 | Scherr George H | Chitosan wound dressing |
| WO2008073403A2 (en) * | 2006-12-12 | 2008-06-19 | Synthasome, Inc. | Composite material for tissue repair |
| CN101466408A (zh) * | 2005-11-02 | 2009-06-24 | 艾里斯治疗公司 | 聚阳离子-聚阴离子络合物、组合物及其使用方法 |
| CN101563116A (zh) * | 2005-07-21 | 2009-10-21 | Fmc生物聚合物联合股份有限公司 | 涂覆有快速溶解的生物相容性涂层的医疗装置 |
| US20090291912A1 (en) * | 2008-04-24 | 2009-11-26 | Medtronic, Inc. | Chitosan-containing protective composition |
| WO2010022132A2 (en) * | 2008-08-19 | 2010-02-25 | The Regents Of The University Of Michigan | Biocompatible coatings, and methods of making and using the same |
| CN101848739A (zh) * | 2007-08-28 | 2010-09-29 | T·阿萨纳夏季斯 | 手术用水凝胶 |
| WO2011075557A1 (en) * | 2009-12-16 | 2011-06-23 | The Trustees Of Columbia University In The City Of New York | Methods, devices, and systems for on-demand ultrasound-triggered drug delivery |
| CN102596275A (zh) * | 2009-09-04 | 2012-07-18 | 亚洲大学校产学协力团 | 用于组织粘合剂的原位成型水凝胶及其生物医学用途 |
| CN103118713A (zh) * | 2010-08-05 | 2013-05-22 | 生命连结有限公司 | 干组合物伤口敷料及粘合剂 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58206751A (ja) | 1982-05-26 | 1983-12-02 | 日石三菱株式会社 | 創傷被覆材 |
| JPS59139310A (ja) | 1983-01-31 | 1984-08-10 | Shiseido Co Ltd | 乳化組成物 |
| JPH0612993B2 (ja) | 1987-08-10 | 1994-02-23 | 株式会社クラレ | 球状の微生物固定化成形物の製造法 |
| US4956350A (en) * | 1988-08-18 | 1990-09-11 | Minnesota Mining And Manufacturing Company | Wound filling compositions |
| FI95207C (fi) | 1992-09-14 | 1996-01-10 | Novasso Oy | Haavansuojaside |
| JP3411602B2 (ja) * | 1992-10-22 | 2003-06-03 | グンゼ株式会社 | キトサンの溶解方法 |
| DE4337152A1 (de) * | 1993-10-30 | 1995-05-04 | Merck Patent Gmbh | Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen |
| US5670169A (en) | 1993-12-20 | 1997-09-23 | E.R. Squibb & Sons, Inc. | Wound hydrating gel with novel preservative system and low cytotoxicity |
| US20020032488A1 (en) | 1994-05-13 | 2002-03-14 | Brekke John H. | Device for regeneration of articular cartilage and other tissue |
| US6150581A (en) * | 1995-06-07 | 2000-11-21 | United States Surgical Corporation | Chitosan/alginate anti-adhesion barrier |
| GB2328443B (en) * | 1997-08-21 | 2001-09-05 | Reckitt & Colmann Prod Ltd | In situ formation of pharmaceutically acceptable polymeric material |
| CA2317582C (en) | 1998-01-06 | 2009-03-31 | Nicholas A. Sceusa | A drug dosage form based on the teorell-meyer gradient |
| JP4241985B2 (ja) | 1998-04-24 | 2009-03-18 | 株式会社クラレ | 医療用接着材 |
| US6200595B1 (en) | 1998-04-24 | 2001-03-13 | Kuraray Co., Ltd. | Medical adhesive |
| JPH11318407A (ja) * | 1998-05-19 | 1999-11-24 | Lion Corp | 加工食品 |
| WO2000012144A1 (en) | 1998-08-31 | 2000-03-09 | Coloplast A/S | A composition capable of absorbing fluid |
| JP4149098B2 (ja) | 1999-09-13 | 2008-09-10 | 株式会社クラレ | 水膨潤性医療用高分子ゲルの製造法及び水膨潤性医療用高分子ゲル |
| US20030206958A1 (en) | 2000-12-22 | 2003-11-06 | Cattaneo Maurizio V. | Chitosan biopolymer for the topical delivery of active agents |
| JP2004041586A (ja) | 2002-07-15 | 2004-02-12 | Fujimori Kogyo Co Ltd | 生体適合性材料およびその製造方法 |
| US7112713B2 (en) | 2003-03-12 | 2006-09-26 | Gelsus Research And Consulting, Inc. | Dressing based on the Teorell-Meyer gradient |
| US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| US8703176B2 (en) * | 2004-02-23 | 2014-04-22 | Loma Linda University Medical Center | Hemostatic agent for topical and internal use |
| US20050203058A1 (en) | 2004-03-11 | 2005-09-15 | Johnson Edwin L. | Compositions of alpha- and beta-chitosan and methods of preparing them |
| MX2007000918A (es) | 2004-07-22 | 2007-12-04 | Hemo Nanoscience Llc | Composiciones y metodos para tratar sangrado excesivo. |
| CN100411690C (zh) * | 2006-01-17 | 2008-08-20 | 武汉理工大学 | 一种抑菌聚电解质多孔材料的制备方法 |
| WO2007112446A2 (en) | 2006-03-28 | 2007-10-04 | University Of Washington | Alginate-based nanofibers and related scaffolds |
| ITPD20060203A1 (it) * | 2006-05-22 | 2007-11-23 | Univ Degli Studi Trieste | Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi |
| US8871247B2 (en) | 2007-02-19 | 2014-10-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| JP4997650B2 (ja) | 2007-06-11 | 2012-08-08 | 国立大学法人京都工芸繊維大学 | 植物の加工方法 |
| US20090041858A1 (en) | 2007-08-06 | 2009-02-12 | Cao Group, Inc. | Haemostatic Compositions Thickened by Polymers Containing Nitrogen Moieties |
| US20090123509A1 (en) | 2007-11-08 | 2009-05-14 | Cory Berkland | Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds |
| US8283384B2 (en) * | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| CN101463144B (zh) * | 2009-01-12 | 2010-12-29 | 武汉理工大学 | 羟丙基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料的制备方法 |
| CN101463145A (zh) * | 2009-01-12 | 2009-06-24 | 武汉理工大学 | 羧甲基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料 |
| WO2010117266A1 (en) | 2009-04-06 | 2010-10-14 | Broockeville Corporation N.V. | In situ gelling alginate systems |
| CN102844053B (zh) | 2009-11-25 | 2015-08-05 | 洛马林达大学医学中心 | 基于壳聚糖的止血织物 |
| US8389498B2 (en) | 2010-03-26 | 2013-03-05 | Taiwan Textile Research Institute | Spinning solution and method for manufacturing biomaterial fibers |
| US8968362B2 (en) | 2010-04-08 | 2015-03-03 | Covidien Lp | Coated looped suture |
| WO2011149907A1 (en) * | 2010-05-24 | 2011-12-01 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| CN102475691B (zh) | 2010-11-30 | 2014-04-16 | 中国科学院大连化学物理研究所 | 海藻酸盐-壳聚糖酰基衍生物微胶囊及其制备和应用 |
| US8911695B2 (en) | 2011-03-17 | 2014-12-16 | Perma-Fix Environmental Services, Inc. | Preparation of chitosan-based microporous composite material and its applications |
| WO2012130031A1 (zh) | 2011-04-01 | 2012-10-04 | 广州奥托沙医药科技有限公司 | 一种医用可吸收骨创面止血材料及其制备方法 |
| GB2499359B (en) | 2011-10-05 | 2016-12-28 | Univ Of Bolton | Polysaccharide fibres for wound dressings |
| CA2855347C (en) * | 2011-11-13 | 2019-03-05 | Suneris Inc. | In-situ cross-linkable polymeric compositions and methods thereof |
| EP2788038A1 (en) | 2011-12-09 | 2014-10-15 | Acell, Inc. | Hemostatic device |
| EP3459522B1 (en) | 2012-12-10 | 2021-02-17 | Regenics AS | Use of egg cellular extracts for wound treatment |
| EP2983718A4 (en) | 2013-04-11 | 2016-12-07 | Univ Of Vermont And State Agricultural College | Decellularization and recellularization of whole organs |
| MX2017016865A (es) | 2015-06-22 | 2018-09-06 | Cresilon Inc | Andamio de polimero adhesivo hermostatico altamente eficaz. |
-
2012
- 2012-11-12 CA CA2855347A patent/CA2855347C/en active Active
- 2012-11-12 MX MX2014005738A patent/MX366366B/es active IP Right Grant
- 2012-11-12 SG SG11201402279SA patent/SG11201402279SA/en unknown
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- 2012-11-12 EP EP12848403.7A patent/EP2776068A4/en not_active Withdrawn
- 2012-11-12 HK HK15102296.0A patent/HK1201734A1/xx unknown
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- 2012-11-12 CN CN201280055699.0A patent/CN103930133A/zh active Pending
- 2012-11-12 US US14/357,342 patent/US20140287061A1/en not_active Abandoned
- 2012-11-12 KR KR1020147015600A patent/KR20140090670A/ko not_active Ceased
- 2012-11-12 AU AU2012334982A patent/AU2012334982A1/en not_active Abandoned
-
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- 2014-04-29 IL IL232330A patent/IL232330B/en active IP Right Grant
- 2014-05-02 ZA ZA2014/03166A patent/ZA201403166B/en unknown
- 2014-05-12 MX MX2019008051A patent/MX2019008051A/es unknown
-
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- 2016-09-15 US US15/266,813 patent/US9687584B1/en active Active
-
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- 2017-06-01 US US15/611,418 patent/US10850003B2/en active Active
- 2017-08-23 AU AU2017219007A patent/AU2017219007A1/en not_active Abandoned
-
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- 2018-06-26 JP JP2018120864A patent/JP7013336B2/ja active Active
-
2020
- 2020-09-14 JP JP2020153716A patent/JP2021007754A/ja not_active Withdrawn
- 2020-10-29 US US17/084,518 patent/US11383005B2/en active Active
Patent Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5836970A (en) * | 1996-08-02 | 1998-11-17 | The Kendall Company | Hemostatic wound dressing |
| JP2000116765A (ja) * | 1998-10-15 | 2000-04-25 | Kuraray Co Ltd | 癒着防止用材料 |
| JP2000186048A (ja) * | 1998-12-22 | 2000-07-04 | Kuraray Co Ltd | 止血材 |
| US20030232746A1 (en) * | 2002-02-21 | 2003-12-18 | Encelle, Inc. | Cross-linked bioactive hydrogel matrices |
| US20070166351A1 (en) * | 2002-06-21 | 2007-07-19 | Advanced Cardiovascular Systems, Inc. | Polycationic peptides for cardiovascular therapy |
| CN101001649A (zh) * | 2004-07-09 | 2007-07-18 | 弗罗桑公司 | 包括透明质酸的止血组合物 |
| CN101563116A (zh) * | 2005-07-21 | 2009-10-21 | Fmc生物聚合物联合股份有限公司 | 涂覆有快速溶解的生物相容性涂层的医疗装置 |
| CN101466408A (zh) * | 2005-11-02 | 2009-06-24 | 艾里斯治疗公司 | 聚阳离子-聚阴离子络合物、组合物及其使用方法 |
| US20070237811A1 (en) * | 2006-04-10 | 2007-10-11 | Scherr George H | Chitosan wound dressing |
| CN1883721A (zh) * | 2006-06-21 | 2006-12-27 | 哈尔滨工业大学 | 共价交联凝胶改性人工植入体的方法 |
| WO2008073403A2 (en) * | 2006-12-12 | 2008-06-19 | Synthasome, Inc. | Composite material for tissue repair |
| CN101848739A (zh) * | 2007-08-28 | 2010-09-29 | T·阿萨纳夏季斯 | 手术用水凝胶 |
| US20100291055A1 (en) * | 2007-08-28 | 2010-11-18 | Theodore Athanasiadis | Surgical hydrogel |
| US20090291912A1 (en) * | 2008-04-24 | 2009-11-26 | Medtronic, Inc. | Chitosan-containing protective composition |
| WO2010022132A2 (en) * | 2008-08-19 | 2010-02-25 | The Regents Of The University Of Michigan | Biocompatible coatings, and methods of making and using the same |
| CN102596275A (zh) * | 2009-09-04 | 2012-07-18 | 亚洲大学校产学协力团 | 用于组织粘合剂的原位成型水凝胶及其生物医学用途 |
| WO2011075557A1 (en) * | 2009-12-16 | 2011-06-23 | The Trustees Of Columbia University In The City Of New York | Methods, devices, and systems for on-demand ultrasound-triggered drug delivery |
| CN103118713A (zh) * | 2010-08-05 | 2013-05-22 | 生命连结有限公司 | 干组合物伤口敷料及粘合剂 |
Non-Patent Citations (2)
| Title |
|---|
| SHAN-HUI HSU ET AL: "Evaluation of Chitosan-alginate-hyaluronate Complexes Modified by an RGD-containing Protein as Tissue-engineering Scaffolds for Cartilage Regeneration", 《ARTIFICIAL ORGANS》 * |
| 胡爱玲等: "《现代伤口与肠造口临床护理实践》", 31 December 2010, 中国协和医科大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111303453A (zh) * | 2020-03-09 | 2020-06-19 | 中国海洋大学 | 一种多重敏感型水凝胶聚合物的制备方法和应用 |
| CN115887738A (zh) * | 2022-12-16 | 2023-04-04 | 湖南师范大学 | 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法 |
| CN115887738B (zh) * | 2022-12-16 | 2024-05-10 | 湖南师范大学 | 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法 |
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