CN109331116B - 一种组合物制剂及其应用 - Google Patents
一种组合物制剂及其应用 Download PDFInfo
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Abstract
本发明涉及一种组合物及该组合物在改善睡眠、预防或治疗失眠方面的应用,该组合物包括酸枣仁、茯苓、γ‑氨基丁酸,还包括甘草和百合。
Description
技术领域
本发明涉及一种组合物及该组合物在改善睡眠、预防或治疗失眠方面的应用,属于食品和医药领域。
背景技术
目前国内失眠等各种慢病高发,国家提倡预防为主,防治慢病、维护健康产品的创研成为研究的热点。失眠是人的一生当中几乎每个人都会碰到的现象,不但影响生活质量,也会造成巨大医疗费用支出。Mellinger的调查女性的患病率是53%,男性是42%,在我国报道中女性的患病率42.7%,男性是28.2%。失眠会引起人的疲劳感、不安、全身不适、无精打采、反应迟缓、头痛、注意力不能集中,严重一点会导致精神分裂和抑郁症、焦虑症、植物神经功能紊乱等功能性疾病,以及各个系统疾病,如心血管系统、消化系统等等。大多数患者长期失眠,越想睡越睡不着,越急越睡不下,由于长期陷入对于睡眠的担心与恐慌中,人会变得多疑、敏感、易怒,以及相当的缺乏自信,这些势必影响其在家庭和工作中各方面的人际关系,从而产生孤独感、挫败感。目前的安眠药和改善睡眠的产品(如褪黑素等)普遍存在副作用大、依赖性强、疗效不显著等缺点,急需开发天然无副作用,安全温和,能有效改善睡眠,预防或治疗失眠的产品来解决患者的痛苦。
发明内容
本发明是提供一种维护身体健康的组合物,尤其这种组合物天然无副作用,安全温和,能有效改善睡眠,预防或治疗失眠。
本发明目的是通过如下技术方案实现的:
一种组合物,主要包括下述重量份的组分:酸枣仁50-150重量份、茯苓1-100重量份、γ-氨基丁酸1-50重量份。
优选的,上述组合物还包括百合1-50重量份、甘草1-20重量份。
优选的,上述组合物包括酸枣仁50-150重量份、茯苓10-100重量份、γ-氨基丁酸5-50重量份、百合5-50重量份、甘草1-20重量份。
优选的,上述组合物包括酸枣仁80-150重量份、茯苓40-100重量份、γ-氨基丁酸10-50重量份、百合10-30重量份、甘草5-15重量份。
更优选的,上述组合物包括酸枣仁150重量份、茯苓100重量份、γ-氨基丁酸50重量份、百合30重量份、甘草5重量份;或酸枣仁100重量份、茯苓50重量份、γ-氨基丁酸30重量份、百合20重量份、甘草15重量份;或酸枣仁120重量份、茯苓70重量份、γ-氨基丁酸20重量份、百合15重量份、甘草10重量份。
优选的,上述组合物包含的植物组分还包括各自的提取物。
优选的,上述组合物包括酸枣仁提取物50-150重量份、茯苓提取物1-100重量份、γ-氨基丁酸1-50重量份、百合提取物1-50重量份、甘草提取物1-20重量份。
优选的,上述组合物包括酸枣仁提取物50-150重量份、茯苓提取物10-100重量份、γ-氨基丁酸5-50重量份、百合提取物5-50重量份、甘草提取物1-20重量份。
优选的,上述组合物包括酸枣仁提取物80-150重量份、茯苓提取物40-100重量份、γ-氨基丁酸10-50重量份、百合提取物10-30重量份、甘草提取物5-15重量份。
更优选的,上述组合物包括酸枣仁提取物150重量份、茯苓提取物100重量份、γ-氨基丁酸50重量份、百合提取物30重量份、甘草提取物5重量份;或酸枣仁提取物100重量份、茯苓提取物50重量份、γ-氨基丁酸30重量份、百合提取物20重量份、甘草提取物15重量份;或酸枣仁提取物120重量份、茯苓提取物70重量份、γ-氨基丁酸20重量份、百合提取物15重量份、甘草提取物10重量份。
本发明组合物通过各组分粉碎或提取、筛分(或不筛分)、按比例混合、包装等常规制备方法制得。
本发明组合物制成的制剂优选包含添加各种辅料制成药品、特殊医学用途食品、保健食品、功能性食品、食品、糖果、饮料等。
本发明组合物制成的制剂优选包含添加辅料制成粉剂、颗粒剂、片剂、胶囊、软胶囊、口服液或糖果。
本发明组合物制成的制剂所用辅料优选包括填充剂、润滑剂、稳定剂、崩解剂、口味改良剂的一种或一种以上。
本发明组合物制成的制剂所用辅料更优选包括微晶纤维素、羧甲基淀粉钠、淀粉、硬脂酸镁、二氧化硅、木糖醇中的一种或一种以上。
与现有技术相比,本发明提供的技术方案具有以下优点:
本发明将酸枣仁、茯苓、γ-氨基丁酸按照一定比例进行配伍,取得了意想不到的协同作用。
本发明进一步发现,将百合和甘草与上述组合物按照一定比例一起进行配伍,取得了更加出众的协同作用。
本发明组合物经急性毒性试验、30天喂养试验研究证实本发明组合物未见任何毒副作用。
具体实施方式
制备例说明:下面结合具有实施方式,对本发明的权利要求做进一步的详细说明,但不构成对本发明的任何限制,任何人在本发明权利要求保护范围内所做的有限次的修改,仍在本发明的权利要求保护范围之内。需要说明的是,本发明提供的技术方案中所采用的原料,未特殊说明外,均通过常规手段制备或者通过商业渠道购买。
实施例1
本发明提供的一种组合物,包括下述重量数的组分:酸枣仁提取物50g;茯苓提取物100g;γ-氨基丁酸1g。
实施例2
本发明提供的一种组合物,包括下述重量数的组分:酸枣仁提取物150g;茯苓提取物1g;γ-氨基丁酸50g。
实施例3
本发明提供的一种组合物,包括下述重量数的组分:酸枣仁提取物100g;茯苓提取物50g;γ-氨基丁酸20g,百合提取物1g;甘草提取物20g。
实施例4
本发明提供的一种组合物,包括下述重量数的组分:酸枣仁提取物100g;茯苓提取物50g;γ-氨基丁酸20g,百合提取物50g;甘草提取物1g。
实施例5
本发明提供的一种组合物,包括下述重量数的组分:酸枣仁提取物120g、茯苓提取物70g、γ-氨基丁酸20g、百合提取物15g、甘草提取物10g。
本发明的组合物的制备方法为:将各组分称量后混合均匀。
实施例说明:为了更好的说明本发明有的优点,下面给出本发明提供的该组合物的功效实验,但不构成对本发明的任何限制。
一、功效实验对比例
对比例1
酸枣仁提取物50g;茯苓提取物100g。
对比例2
酸枣仁提取物150g;γ-氨基丁酸50g。
对比例3
酸枣仁提取物100g;茯苓提取物50g;γ-氨基丁酸20g;甘草提取物20g。
对比例4
酸枣仁提取物100g;茯苓提取物50g;γ-氨基丁酸20g;百合提取物50g。
对比例5
某公开的改善睡眠优化组方:酸枣仁提取物100g;茯苓提取物38g;百合提取物54g;大枣提取物26g;甘草提取物2g。
对比例6
某市售褪黑素产品。
二、改善睡眠评价实验
1、测试样品:取实施例1-5以及对比例1-5制备的组合物,添加玉米淀粉至250g,混匀后灌装胶囊,每粒250mg。
2、实验方法:选年龄在18-80岁,能看懂匹茨堡睡眠质量指数量表,获知情同意,能配合随访,PSQI测评超过13分,排除其他安全性隐患的志愿者55名。按志愿者PSQI测评分数等比例分为11组,同时考虑影响结果的各种因素包括性别、年龄、睡眠习惯和职业特点等,尽可能保证组间均衡。
各组志愿者睡前1h服用由实施例1-5以及对比例1-5制备的胶囊3粒,对比例6按产品说明书服用(1粒)。试验期间不改变受试者原来的饮食习惯,正常饮食。连续30d。试食结束时重新进行一次PSQI测评。期间随访。
3、实验结果:各组志愿者试食30d前后PSQI测评总分变化如表1所示。各组试吃后均较试吃前评分有所下降,除对比例1和对比例2外,其他各组试吃后较试吃前有显著性差异(P<0.05)。实施例1-5较对比例5-6差异显著(P<0.05)。实施例3-5较对比例3-4差异显著(P<0.05)。实施例5试吃后较试吃前评分下降最多。
4、讨论:上述实验结果表明实施例1-2所代表的组合物具有显著的改善睡眠作用,且其作用显著好于市面销售的褪黑素产品及已公开的改善睡眠优化组方。酸枣仁、茯苓、γ-氨基丁酸按照一定比例进行配伍取得了意想不到的协同作用。在此基础之上,进一步优化所得的实施例3-5所代表的组合物取得了更加显著的改善睡眠作用。百合和甘草与上述组合物按照一定比例一起进行配伍,取得了意想不到的、更加出众的协同作用。
Claims (8)
1.一种组合物,其特征在于,由以下重量份的组分组成:酸枣仁50-150重量份、茯苓1-100重量份、γ-氨基丁酸1-50重量份、百合1-50重量份、甘草1-20重量份。
2.一种组合物,其特征在于,由以下重量份的组分组成:
酸枣仁提取物50-150重量份、茯苓提取物1-100重量份、γ-氨基丁酸提取物1-50重量份、百合提取物1-50重量份、甘草提取物1-20重量份。
3.如权利要求2所述的组合物,其特征在于,所述组合物由以下重量份的组分组成:
酸枣仁提取物150重量份、茯苓提取物100重量份、γ-氨基丁酸50重量份、百合提取物30重量份、甘草提取物5重量份;
或酸枣仁提取物100重量份、茯苓提取物50重量份、γ-氨基丁酸30重量份、百合提取物20重量份、甘草提取物15重量份;
或酸枣仁提取物120重量份、茯苓提取物70重量份、γ-氨基丁酸20重量份、百合提取物15重量份、甘草提取物10重量份。
4.如权利要求1-3任一项所述的组合物在制备改善睡眠作用制剂中的应用。
5.如权利要求4所述的应用,其特征在于,所述组合物制剂为保健食品。
6.如权利要求4所述的应用,其特征在于,所述组合物添加辅料制成粉剂、颗粒剂、片剂、胶囊、或口服液。
7.如权利要求6所述的应用,其特征在于所述辅料包括填充剂、润滑剂、稳定剂、崩解剂、口味改良剂的一种或一种以上。
8.如权利要求6所述的应用,其特征在于所述辅料包括微晶纤维素、羧甲基淀粉钠、淀粉、硬脂酸镁、二氧化硅、木糖醇中的一种或一种以上。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE202004018534U1 (de) * | 2004-11-30 | 2005-04-28 | Gerent Biotech Co | Kräuterzusammensetzung zur Vermeidung und/oder Behandlung von Zuständen in Verbindung mit Depression |
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CN108671140A (zh) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | 一种改善睡眠的组合物及其应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN105725211A (zh) * | 2016-03-04 | 2016-07-06 | 广州万康保健品有限公司 | 一种用于改善睡眠的食品保健品及其制备方法 |
CN108671140A (zh) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | 一种改善睡眠的组合物及其应用 |
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